TMS for iEEG Monitoring Recordings

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
University of Pennsylvania
Study ID
NCT07518745
Status
Enrolling By Invitation

Conditions

  • EEG
  • TMS

Eligibility Criteria

Sex
ALL
Age
21 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Single Pulse TMS — DEVICE
    single pulse TMS will be administered when participants have intracranial electrodes implanted to measure neuronal activity.

Study Details

The current study presents a unique opportunity to measure the direct effects of transcranial magnetic stimulation (TMS) by using intracranial electrodes to record neural activity in deep brain regions when TMS single pulses are delivered. If TMS can evoke downstream responses in neural networks of the human brain, it can be a feasible way to study circuit engagement and connectivity.

Key Dates

Start date
Nov 11, 2025
Status verified
Apr 2026
Primary completion
Oct 11, 2029
Completion
Nov 11, 2029

Study Design

Enrollment
10 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: TMS
    The study visit consists of a TMS single-pulse session when intracranial electrodes are implanted to record neural activity during the TMS session.

Primary Outcome Measure

Primary Endpoint #1 Brain Activity and Connectivity [ Time Frame: From enrollment to the end of study participation at 5 weeks ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of PennsylvaniaPhiladelphiaPennsylvania19107-

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By research site
University of Pennsylvania· Philadelphia, PA

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