GI oncology Clinical Trials in Philadelphia, PA

As of June 2026, 64 paid clinical trials are recruiting for GI oncology in Philadelphia, Pennsylvania. GI oncology trials cover colorectal, pancreatic, gastric, esophageal, liver, and biliary cancers — testing chemotherapy combinations, targeted agents, and immunotherapy for microsatellite-instability-high tumors. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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64 clinical trials for GI oncology

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A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

for Advanced Solid Tumors With KRAS G12C Mutations

15 locations incl. La Jolla

Sponsor: Frontier Medicines Corporation

Sex: All·Age: 18+

Code: NCT06244771·Phase 1, Phase 2·Recruiting

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A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer

for Esophageal Cancer

10 locations incl. Boston

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06123338·Phase 2·Recruiting

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National Liver Cancer Screening Trial

for Carcinoma, Hepatocellular

18 locations incl. Los Angeles

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 85

Code: NCT06084234·Phase 4·Recruiting

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Combination of GNS561 and Trametinib in Patients With Advanced KRAS Mutated Cholangiocarcinoma

for Cholangiocarcinoma

Drug: Trametinib

10 locations incl. Los Angeles

Sponsor: Genfit

Sex: All·Age: 18+

Code: NCT05874414·Phase 1, Phase 2·Recruiting

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FOG-001 in Locally Advanced or Metastatic Solid Tumors

for Cancer

31 locations incl. Phoenix

Sponsor: Parabilis Medicines, Inc.

Sex: All·Age: 18+

Code: NCT05919264·Phase 1, Phase 2·Recruiting

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Collection of Circulating Biomarkers in Pancreatic Cancer

for Pancreas Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT05743049·Recruiting

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Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia

for Barretts Esophagus With Dysplasia

23 locations incl. Los Angeles

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 89

Code: NCT05753748·Recruiting

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SBRT With Atezo/Bev for HCC

for Hepatocellular Carcinoma

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18 - 99

Code: NCT05488522·Phase 1·Recruiting

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Neratinib and Fam-Trastuzumab Deruxtecan in Advanced Gastro-esophageal Cancer Patients

for Gastric Cancer

3 locations incl. Palo Alto

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 18+

Code: NCT05274048·Phase 1·Recruiting

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Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

for Colorectal Carcinoma

9 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05410977·Recruiting

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Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

for Colorectal Carcinoma

21 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 12 Months - 30

Code: NCT04851119·Phase 1, Phase 2·Recruiting

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ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

for Bladder Carcinoma

33 locations incl. Birmingham

Sponsor: Guardant Health, Inc.

Sex: All·Age: 18+

Code: NCT05059444·Recruiting

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CTNNA1 Familial Expansion Study

for Cancer Gene Mutation

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT05126290·Recruiting

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A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

for Advanced Cancer

40 locations incl. Birmingham

Sponsor: Artios Pharma Ltd

Sex: All·Age: 18+

Code: NCT04657068·Phase 1, Phase 2·Recruiting

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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

for Advanced Solid Tumor

32 locations incl. Irvine

Sponsor: PMV Pharmaceuticals, Inc

Sex: All·Age: 12+

Code: NCT04585750·Phase 1, Phase 2·Recruiting

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Pancreatic Cancer Early Detection Consortium

for Pancreas Cancer

45 locations incl. Phoenix

Sponsor: Arbor Research Collaborative for Health

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT04970056·Recruiting

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Efficacy and Safety of the CG-100 Intraluminal Bypass Device

for Rectal Cancer

10 locations incl. Orange

Sponsor: Colospan Ltd.

Sex: All·Age: 22 - 70

Code: NCT04184973·Recruiting

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Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

for Metastatic Uveal Melanoma

12 locations incl. Los Angeles

Sponsor: IDEAYA Biosciences

Sex: All·Age: 18+

Code: NCT03947385·Phase 1, Phase 2·Recruiting

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Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer

for Colorectal Neoplasms

6 locations incl. Duarte

Sponsor: Surgimab

Sex: All·Age: 18+

Code: NCT03659448·Phase 3·Recruiting

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SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

for Cancer, Metastatic

67 locations incl. Birmingham

Sponsor: Massive Bio, Inc.

Sex: All·Age: All ages

Code: NCT03452774·Recruiting

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Initial Feasibility Study to Treat Borderline Resectable Pancreatic Cancer With a Planar LDR Source

for Pancreatic Cancer

6 locations incl. Tampa

Sponsor: CivaTech Oncology

Sex: All·Age: 18+

Code: NCT02843945·Phase 1, Phase 2·Recruiting

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Preliminary Evaluation of Screening for Pancreatic Cancer in Patients With Inherited Genetic Risk

for Pancreatic Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT02478892·Recruiting

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Dose-defining Study of Tirapazamine Combined With Embolization in Liver Cancer

for Hepatocellular Carcinoma

2 locations incl. Palo Alto

Sponsor: Teclison Ltd.

Sex: All·Age: 20 - 99

Code: NCT02174549·Phase 1, Phase 2·Recruiting

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The Cancer of the Pancreas Screening-5 CAPS5)Study

for Pancreas Cancer

9 locations incl. New Haven

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT02000089·Phase 3·Recruiting

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Conditions in GI oncology (Philadelphia, PA)

Colorectal cancer· 24 Pancreatic cancer· 18 Gastric cancer· 13 Liver cancer· 10 Esophageal cancer· 8 Biliary tract cancer· 7 Gastroesophageal junction cancer· 5 Metastatic colorectal cancer· 3 Gastrointestinal cancer· 2 Rectal cancer· 1