Behavioral health Clinical Trials in Philadelphia, PA

As of June 2026, 75 paid clinical trials are recruiting for Behavioral health in Philadelphia, Pennsylvania. Behavioral health trials span mental-health pharmacotherapy and addiction treatment — testing new agents and therapies for depression, anxiety, opioid use disorder, alcohol use, and tobacco cessation. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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75 clinical trials for Behavioral health

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Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

for Major Depressive Disorder

Drug: NBI-1065845

40 locations incl. Huntsville

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18+

Code: NCT06966401·Phase 3·Recruiting

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Improving Mood for Adolescents Through Teaming With End-Users in Routine Care (The iMATTER Project)

for Depressive Symptoms

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 13 - 17

Code: NCT07020572·Recruiting

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Antidepressant Adherence for Depressed Adults in Primary Care

for Depression

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 21 - 64

Code: NCT06496646·Recruiting

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The Collaborative Care PrTNER Study

for HIV

2 locations incl. Baltimore

Sponsor: Children's Hospital of Philadelphia

Sex: Male·Age: 15 - 29·Accepts healthy volunteers

Code: NCT06585631·Recruiting

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A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

for Treatment Resistant Depression

34 locations incl. Tucson

Sponsor: atai Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT06524830·Phase 2·Recruiting

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Adolescent Outcomes of Post-operative Opioid EXposure

for Opioid Use Disorder

5 locations incl. Aurora

Sponsor: Sharon Levy

Sex: All·Age: 12 - 17

Code: NCT06350409·Recruiting

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Enhancing Memory in CPT for PTSD

for Stress Disorders, Post-Traumatic

1 location in Philadelphia

Sponsor: VA Office of Research and Development

Sex: All·Age: 60+

Code: NCT06000475·Recruiting

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Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

for E-cigarette Use

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06372899·Recruiting

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Intermittent Theta Burst Stimulation (iTBS) for Emotion Regulation in Bipolar Disorder

for Bipolar Disorder

2 locations incl. Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 24 - 65

Code: NCT06274567·Recruiting

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Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

for Treatment Resistant Depression

24 locations incl. Birmingham

Sponsor: Abbott Medical Devices

Sex: All·Age: 22 - 70

Code: NCT06423430·Recruiting

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Postpartum Care in the NICU (PeliCaN) Transitions

for Stress Disorders, Post-Traumatic

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 16+

Code: NCT06521398·Recruiting

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Refer2Quit: Evaluating a Proactive, Tailored, Population Health Approach for Tobacco Treatment for Household Smokers Through a Pediatric Care Network

for Smoking

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 18+

Code: NCT06582693·Recruiting

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Taking Action for College Students

for Major Depressive Disorder

1 location in Philadelphia

Sponsor: Temple University

Sex: All·Age: 18+

Code: NCT06700902·Recruiting

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The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers

for Smoking

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06264154·Recruiting

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An Intervention Mapping Approach to Closing the Gap in Maternal OUD and Infant NAS Care (SUPPORT)

for Opioid Use Disorder

3 locations incl. Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06576323·Recruiting

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A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation

for Posttraumatic Stress Disorder

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 60

Code: NCT06234969·Recruiting

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Evaluate the Effects of Long-term Use of Psychotropic Medications on Eye Movement Patterns With the Gaize Device

for ADHD

1 location in Philadelphia

Sponsor: Gaize

Sex: All·Age: 18 - 65

Code: NCT07389473·Recruiting

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Text-Messaging Telehealth and Contingency Management for Opioid Use Disorder Treatment Engagement

for Opioid Use Disorder

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05897788·Recruiting

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Effects of Ketone Supplementation on Acute Alcohol Withdrawal

for Alcohol Use Disorder

2 locations incl. Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 75

Code: NCT06173973·Phase 2, Phase 3·Enrolling By Invitation

Getting Out of the House: Using Behavioral Activation to Increase Community Participation

for Major Depressive Disorder

1 location in Philadelphia

Sponsor: Temple University

Sex: All·Age: 18+

Code: NCT06336616·Recruiting

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Pregabalin Plus Lofexidine for the Outpatient Treatment of Opioid Withdrawal

for Opiate Withdrawal Syndrome

2 locations incl. Baltimore

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05995535·Phase 2·Recruiting

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Integrating Brain, Neurocognitive, and Computational Tools in OUD

for Opioid Use Disorder

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 60

Code: NCT06136247·Recruiting

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AWARE: Management of ADHD in Autism Spectrum Disorder

for ADHD

10 locations incl. Irvine

Sponsor: Daniel Coury

Sex: All·Age: 4 - 17

Code: NCT05916339·Phase 4·Recruiting

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Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

for Major Depressive Disorder

24 locations incl. Huntsville

Sponsor: Intra-Cellular Therapies, Inc.

Sex: All·Age: 18 - 65

Code: NCT05850689·Phase 3·Recruiting

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SEEG-Guided DBS for OCD

for Obsessive-Compulsive Disorder

2 locations incl. Stanford

Sponsor: Casey H. Halpern, M.D.

Sex: All·Age: 22 - 75

Code: NCT05623306·Recruiting

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Decoding and Modulating Affective Brain States

for Rumination

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 65

Code: NCT05437705·Recruiting

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Naltrexone in AUD Reward Drinkers

for Alcohol Use Disorder

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 65

Code: NCT05028062·Phase 4·Recruiting

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Triage Survey for Psychiatry Research Eligibility

for Major Depressive Disorder

6 locations incl. Boston

Sponsor: Adams Clinical

Sex: All·Age: 18+

Code: NCT05800925·Recruiting

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Relationship Between Brain and Heart Glucose Metabolism in Alcohol Use Disorder

for Alcohol Use Disorder (AUD)

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 21 - 65·Accepts healthy volunteers

Code: NCT05015881·Phase 2, Phase 3·Enrolling By Invitation

Ketone Ester Intervention in Alcohol Use Disorder

for Alcohol Drinking

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 21 - 65·Accepts healthy volunteers

Code: NCT04616781·Phase 2, Phase 3·Recruiting

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A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder

for Opioid Use Disorder

25 locations incl. Tuscaloosa

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT04375033·Phase 4·Recruiting

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MIO-CPP to Improve the Well-being, Permanency, and Safety Outcomes for Young Children at Risk of or in Out-of-home Placement in Philadelphia and Bucks Counties, and Affected by Maternal Substance Use

for Substance Use Disorders

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: Female·Age: All ages

Code: NCT04294134·Enrolling By Invitation

A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

for Treatment Resistant Depression

98 locations incl. Birmingham

Sponsor: LivaNova

Sex: All·Age: 18+

Code: NCT03887715·Recruiting

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Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological Symptoms as Correlates

for Schizophrenia

1 location in Philadelphia

Sponsor: Corporal Michael J. Crescenz VA Medical Center

Sex: All·Age: 18 - 75

Code: NCT03495024·Phase 4·Recruiting

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Evaluation of the PACE/PACENET BHL Clinical Program

for Depression

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 65+

Code: NCT02463266·Recruiting

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Conditions in Behavioral health (Philadelphia, PA)

Depression· 22 Opioid use disorder· 15 Alcohol use disorder· 11 Schizophrenia· 9 Anxiety· 6 Tobacco / nicotine use· 5 PTSD (post-traumatic stress disorder)· 4 Bipolar disorder· 4 ADHD· 3 Substance use disorder· 2 Obsessive-compulsive disorder (OCD)· 1