A Mechanistic Trial of the Neurobiology of Extinction Learning and Intraparietal Sulcus Stimulation

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
University of Pennsylvania
Study ID
NCT06234969
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 60 Years
Healthy Volunteers
Not accepted

Interventions

  • Continuous Theta Burst Stimulation to the Intraparietal Sulcus — DEVICE
    Continuous Theta Burst Stimulation delivered to the Intraparietal Sulcus
  • Sham Continuous Theta Burst Stimulation — DEVICE
    Sham Continuous Theta Burst Stimulation

Study Details

This study will be the first of its kind to explore the impact of continuous theta burst stimulation (cTBS) to the intraparietal sulcus (IPS) on arousal symptoms among patients with posttraumatic stress disorder (PTSD). The investigators will demonstrate that IPS cTBS results in significant reduction in arousal (measured by startle response) compared to sham cTBS, that IPS cTBS interacts with extinction training to further improve arousal, and that there is a dose/response effect of cTBS on arousal. The investigators will also demonstrate that IPS cTBS significantly improves retention of extinction learning, the experimental analogue of exposure therapy.

Key Dates

Start date
Apr 29, 2024
Status verified
Oct 2025
Primary completion
Jul 31, 2028
Completion
Oct 31, 2028

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Continuous theta burst stimulation to the intraparietal sulcus
    Continuous theta burst stimulation will be delivered to the individually targeted intraparietal sulcus site at 100% RMT.
  • Placebo Comparator: Sham continuous theta burst stimulation
    We will use the coil's electric stimulation functionality that allows for the delivery of a brief electric pulse to the scalp simultaneous to the pulse to mimic actual stimulation.

Primary Outcome Measure

Electromyography startle response [ Time Frame: Days 4, 5, 34 and 35 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Center for the Treatment and Study of Anxiety, University of PennsylvaniaPhiladelphiaPennsylvania19104
Lily A Brown, PhD
[email protected]
215-746-3346
Sonalee Joshi, PhD
[email protected]
21-746-3342

Find similar trials in Philadelphia, PA

By condition
PTSD (post-traumatic stress disorder)
By specialty
PsychiatryMental healthBehavioral health
By research site
Center for the Treatment and Study of Anxiety, University of Pennsylvania· Philadelphia, PA

Related Studies