Enhancing Memory in CPT for PTSD

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
VA Office of Research and Development
Study ID
NCT06000475
Status
Recruiting
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Conditions

  • Stress Disorders, Post-Traumatic

Eligibility Criteria

Sex
ALL
Age
60 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Cognitive Processing Therapy — BEHAVIORAL
    CPT as described in the treatment manual
  • Cognitive Processing Therapy (CPT) + Memory Support — BEHAVIORAL
    CPT+Memory support will also incorporate frequent and intentional use of strategies to enhance learning and memory of this content.

Study Details

Several psychotherapies for posttraumatic stress disorder (PTSD) have a strong evidence base for their efficacy, but nonresponse rates are high, particularly among older Veterans. Accumulating evidence indicates that memory deficits and poor learning of therapy contents adversely affect psychotherapy treatment response in PTSD. However, limited research has examined methods for increasing learning of therapy contents in psychotherapy for PTSD. The proposed study aims to examine the feasibility of integrating an intervention to increase learning and memory of psychotherapy content into the provision of a widely used psychotherapy, cognitive processing therapy (CPT), for older adults with PTSD. The ultimate goal of this line of research is to develop novel rehabilitation interventions to increase functioning for individuals with PTSD.

Key Dates

Start date
Oct 15, 2024
Status verified
Oct 2025
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Active Comparator: Cognitive Processing Therapy (CPT)
    Standard CPT as described in the treatment manual
  • Experimental: Cognitive Processing Therapy (CPT) + Memory Support
    CPT+Memory support will also incorporate frequent and intentional use of strategies to enhance learning and memory of this content.

Primary Outcome Measure

PTSD Checklist-5 (PCL-5) [ Time Frame: Through study completion, weeks 12-16 of treatment ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PAPhiladelphiaPennsylvania19104-4551
Kyong-Mi Chang, MD
[email protected]
215-823-5893
Richard A Moore
[email protected]
(215) 823-5800
James C. Scott, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA· Philadelphia, PA

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