Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,661 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 15, 2026.

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3,661 clinical trials

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An Ophthalmic Safety Study in Patients With Breast Cancer

for Ophthalmic Safety in Patients With Breast Cancer

12 locations incl. La Jolla

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06767462·Recruiting

Apply to this trial

Expiratory Muscle Strength Training for Hypernasal Speech in Children

for Velopharyngeal Insufficiency

1 location in Pittsburgh

Sponsor: Noel Jabbour

Sex: All·Age: 5 - 17

Code: NCT05492266·Recruiting

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A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines

for Psoriatic Arthritis

Drug: Zasocitinib

54 locations incl. Chandler

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06671483·Phase 3·Recruiting

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A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure

for Chronic Kidney Disease and Hypertension

Drug: Dapagliflozin

132 locations incl. Fairhope

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06742723·Phase 3·Recruiting

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Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

for Major Depressive Disorder (MDD)

21 locations incl. Phoenix

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 18 - 65

Code: NCT06830044·Phase 3·Recruiting

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Scrambler Therapy With Duloxetine-based Usual Care vs Duloxetine-based Usual Care for Chemotherapy-induced Peripheral Neuropathy.

for CIPN - Chemotherapy-Induced Peripheral Neuropathy

1 location in Philadelphia

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 18+

Code: NCT06914557·Phase 2·Recruiting

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Traumatic Hemothorax Drainage and Daily Lavage

for Hemothorax

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 15+

Code: NCT06937450·Recruiting

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Advanced Neuroimaging in Idiopathic Intracranial Hypertension

for Idiopathic Intracranial Hypertension (IIH)

1 location in Philadelphia

Sponsor: Thomas Jefferson University

Sex: All·Age: 18 - 55

Code: NCT06950099·Recruiting

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Efficacy and Safety of Phentermine/Topiramate in Youth With Hypothalamic Obesity

for Hypothalamic Obesity

2 locations incl. Philadelphia

Sponsor: Seattle Children's Hospital

Sex: All·Age: 6 - 28

Code: NCT06299891·Phase 2·Recruiting

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A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

for HER2-positive Gastric Cancer

Drug: Rilvegostomig

53 locations incl. Anchorage

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06764875·Phase 3·Recruiting

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Role of Menopause in Thermoregulation

for Menopause

1 location in University Park

Sponsor: Penn State University

Sex: Female·Age: 42 - 64·Accepts healthy volunteers

Code: NCT06798571·Phase 4·Recruiting

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Impact of Depression on Thermoregulation

for Depression

1 location in University Park

Sponsor: Penn State University

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT06805851·Recruiting

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Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0

for Acute Kidney Injury

50 locations incl. Birmingham

Sponsor: Indiana University

Sex: All·Age: 0 Minutes - 2 Weeks

Code: NCT06823115·Enrolling By Invitation

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

for Advanced Solid Tumor

21 locations incl. Scottsdale

Sponsor: Clasp Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06778863·Phase 1·Recruiting

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A Self-Guided Mobile Intervention for Adults With Binge Eating and Obesity

for Binge Eating Disorder Associated With Obesity

1 location in Philadelphia

Sponsor: Drexel University

Sex: All·Age: 18 - 70

Code: NCT06817863·Phase 1, Phase 2·Recruiting

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Use of SPY Imaging System to Minimize Fistulas After Hypopharyngeal Reconstruction

for Squamous Cell Carcinoma

1 location in Pittsburgh

Sponsor: Matthew Spector

Sex: All·Age: 18+

Code: NCT06831149·Phase 2·Recruiting

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Rollover Study for Participants Previously Enrolled in Clinical Trials of Povorcitinib

for Hidradenitis Suppurativa (HS)

Drug: Povorcitinib

108 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT06855498·Phase 3·Recruiting

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Temple Health Chest Initiative (THCI 2.0)

for Chronic Obstructive Pulmonary Disease (COPD)

1 location in Philadelphia

Sponsor: Temple University

Sex: All·Age: 50 - 80·Accepts healthy volunteers

Code: NCT06933758·Recruiting

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Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer

for Hematopoietic and Lymphatic System Neoplasm

190 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: Female·Age: Up to 39

Code: NCT06513962·Phase 3·Recruiting

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A Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

for Immune Thrombocytopenic Purpura (ITP)

18 locations incl. Los Angeles

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06722235·Phase 3·Recruiting

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Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer

for Gastric Cancer

18 locations incl. New Haven

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06731478·Phase 3·Recruiting

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Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1

for Non-Small Cell Lung Cancer

Drug: Ivonescimab

89 locations incl. Chandler

Sponsor: Summit Therapeutics

Sex: All·Age: 18+

Code: NCT06767514·Phase 3·Recruiting

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Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy

for Prostate Cancer

27 locations incl. Los Angeles

Sponsor: Novartis Pharmaceuticals

Sex: Male·Age: 18 - 100

Code: NCT06780670·Phase 2, Phase 3·Recruiting

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Acceptance and Commitment Therapy Integrated Vestibular Rehabilitation (ACTIVE) RCT

for Concussion, Mild

2 locations incl. Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 49

Code: NCT06819904·Recruiting

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Sirolimus for Leigh Syndrome

for Leigh Syndrome

1 location in Philadelphia

Sponsor: Matthew Demczko

Sex: All·Age: 6 Months - 55

Code: NCT06843811·Phase 2·Enrolling By Invitation

Prokinetics and Body Surface Gastric Mapping in Dyspeptic Patients: Baseline and Treatment Effects

for Gastroparesis

1 location in Philadelphia

Sponsor: University of Auckland, New Zealand

Sex: All·Age: 18+

Code: NCT06854120·Recruiting

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A 3-part Study of SYX-5219 in Healthy Volunteers and Participants With Atopic Dermatitis

for Moderate to Severe Atopic Dermatitis

6 locations incl. Arkansas City

Sponsor: Sitryx Therapeutics Ltd

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07558668·Phase 1·Recruiting

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Identifying Patterns in the Breath of Individuals With Breast Cancer

for Breast Cancer

4 locations incl. Washington D.C.

Sponsor: Breathe BioMedical Inc

Sex: Female·Age: 40 - 74·Accepts healthy volunteers

Code: NCT06512350·Recruiting

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Transitional Housing and HIV Health

for HIV

2 locations incl. Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06829394·Recruiting

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Neurometabolic Profile of Individuals With Primary Mitochondrial Disease

for Primary Mitochondrial Disease

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 8 - 75·Accepts healthy volunteers

Code: NCT06890520·Recruiting

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Retrospective Analyses of TrakStar Database

for Depression

1 location in Malvern

Sponsor: Neuronetics

Sex: All·Age: 5 - 120

Code: NCT06917339·Recruiting

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Phase 1b/2a Randomized Double-blind Study to Investigate Safety Tolerability PK PD Preliminary Efficacy of Oral Administration of SNIPR001 in Patients With Hematologic Malignancy Scheduled for Allogeneic Hematopoietic Stem-Cell Transplant Receiving FQ Prophylaxis & Harboring FQR Ecoli Pre-Transplant

for E Coli Infections

8 locations incl. Duarte

Sponsor: SNIPR Biome Aps.

Sex: All·Age: 18+

Code: NCT06938867·Phase 1, Phase 2·Recruiting

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Prevail Global Study

for Coronary Artery Disease

51 locations incl. Birmingham

Sponsor: Medtronic Vascular

Sex: All·Age: 18+

Code: NCT06535854·Recruiting

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Systemic Oral Glucocorticoids for the Treatment of Acute Osteoarthritis Pain in the Emergency Department

for Osteoarthritis

1 location in York

Sponsor: WellSpan Health

Sex: All·Age: 18+

Code: NCT06603662·Phase 4·Recruiting

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SSVC-CI During CABG

for Coronary Artery Bypass Grafting Surgery (CABG)

1 location in Hershey

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 18+

Code: NCT06645327·Recruiting

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Understanding the Preferences and Views of Older Adults on the Use of Geriatric and Objective Functional Assessments for Cancer Treatment Planning.

for Care Delivery

1 location in Philadelphia

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 65+

Code: NCT06652347·Recruiting

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A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease

for Huntington Disease

5 locations incl. Boston

Sponsor: Hoffmann-La Roche

Sex: All·Age: 25 - 65

Code: NCT06826612·Phase 1, Phase 2·Recruiting

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Effects of Anti-PD1 Adjuvant Checkpoint Blockade Immunotherapy on Atypical/Dysplastic Nevi

for Melanoma

1 location in Pittsburgh

Sponsor: John Kirkwood

Sex: All·Age: 18+

Code: NCT06599619·Recruiting

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SNV4818 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

5 locations incl. Los Angeles

Sponsor: Pikavation Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06736704·Phase 1, Phase 2·Recruiting

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Communication About Sexual Health in Gynecologic Cancer

for Gynecologic Cancers

1 location in Philadelphia

Sponsor: Fox Chase Cancer Center

Sex: Female·Age: 18+

Code: NCT06904339·Recruiting

Apply to this trial