Oncology Clinical Trials in Newport Beach, CA
As of June 2026, 77 paid clinical trials are recruiting for Oncology in Newport Beach, California. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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77 clinical trials for Oncology
·Clear filters·↓ Download CSVImmunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial
Evaluation of the Safety and Efficacy of Abenacianine (VGT-309) to Identify Cancer in Subjects Undergoing Surgery for Cancer in the Lung
A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer
Metastatic Non-Familial Adenocarcinoma Maintenance Therapy With DZ-002: Heptamine Carboxymethine Dye Conjugate
A Multicenter Prospective Observational Cohort Study Evaluating the Impact of Cancer-Directed Treatment and Medication Use, Including Cannabis Use, in Multiple Myeloma Patients
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
Development and Application of Patient-Derived Models of Cancer
A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies
A Study to Investigate Safety and Effectiveness of CRN09682 in Participants With SST2-Expressing NENs and Other Solid Tumors
A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)
Mobile Health Intervention to Improve Adherence to Oral Anticancer Therapy
A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors
A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)
Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer
Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors
SLV-154 Treatment of Metastatic Solid Tumors
PTM-101 in Pancreatic Ductal Adenocarcinoma (PDAC)
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma
A Phase 1 Study of LNCB74 in Advanced Solid Tumors
Study of Belzutifan (MK-6482) Plus Fulvestrant for ER+/HER2- Metastatic Breast Cancer (MK-6482-029/LITESPARK-029)
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors
A Phase I/II, Dose Finding and Optimization Study of [177Lu]Lu-NeoB in Combination With Capecitabine in Patients With GRPR+, ER+, HER2- Metastatic Breast Cancer After Progression on Previous Endocrine Therapy in Combination With a CDK4/6 Inhibitor.
N-803 and PD-L1 t-haNK Combined With Bevacizumab for Recurrent or Progressive Glioblastoma
Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer
A Study Evaluating Atezolizumab, With or Without Bevacizumab, in Participants With Unresectable Hepatocellular Carcinoma and Child-pugh B7 and B8 Cirrhosis
A Validation Study to Determine Concordance of Liquid Biopsy and Breast Cancer Diagnosis
Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
Copper Cu 64 PSMA I&T PET Imaging in Men With Newly Diagnosed Prostate Cancer
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
First-in-Human Study of OKI-219 in Advanced Solid Tumors and Advanced Breast Cancer
MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)
A Study of KK2269 in Adult Participants With Solid Tumors
About research studies in Newport Beach
Newport Beach has approximately 215 recruiting research studies across a wide range of therapeutic areas. California hosts a dense network of world-class research institutions, including UC San Diego Health, Stanford Medicine, UCLA Health, UCSF, City of Hope, and Scripps Research. The state's thriving biotech corridor and diverse patient population make it a national hub for both early-phase and late-phase clinical research.
Top Research Study Locations in Newport Beach
Researchers run research studies in Newport Beach, CA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Hoag Memorial Hospital Presbyterian | Breast Cancer, Advanced Solid Tumor, Advanced Breast Cancer | 54 |
| USC Norris Oncology/Hematology-Newport Beach | Advanced Esophageal Adenocarcinoma, Advanced Gastric Adenocarcinoma, Advanced Gastroesophageal Junction Adenocarcinoma | 24 |
| Hoag Memorial Hospital | Advanced Solid Tumor, Head and Neck Squamous Cell Carcinoma, Advanced Solid Tumors | 11 |
| Eye Research Foundation | Dry Eye Disease (DED), Ocular Hypertension, Glaucoma, Open-Angle | 8 |
| City of Hope Newport Beach | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8 | 7 |
| City of Hope at Newport Beach Fashion Island | Lung Non-Small Cell Carcinoma, Metastatic Pancreatic Adenocarcinoma, Multiple Myeloma | 5 |
| Hoag Family Cancer Institute | Advanced Metastatic Castration Resistant Prostate Cancer, Advanced NET of GI Origin, Advanced or Metastatic Solid Tumors | 5 |
| NewportNativeMD, Inc. | Asthma, Interstitial Lung Disease, Moderate to Severe Chronic Obstructive Pulmonary Disease | 5 |
| Hoag Hospital | Abdominal Aortic Aneurysm, Abdominal Aortic Aneurysm >= 5.0 Centimeters in Female (Disorder), Abdominal Aortic Aneurysm >= 5.5 Centimeters in Male (Disorder) | 4 |
| Hoag Hospital Newport Beach | Anaplastic Lymphoma Kinase-positive, Atrial Fibrillation, Crohn's Disease | 4 |
| Hoag | Benign Liver Tumor, Genetic Predisposition, Liver Neoplasms | 4 |
| Akero Clinical Study Site | MASH - Metabolic Dysfunction-Associated Steatohepatitis, MASH With Fibrosis, NASH - Nonalcoholic Steatohepatitis | 2 |
| Hoag Gynecologic Oncology | Cervical Cancer, Endometrioid Ovarian Cancer, Fallopian Tube Cancer | 2 |
| Hoag Memorial Hospital Presbyterian;Hoag Center for Research and Education | Moderately to Severely Active Crohns Disease, Moderately to Severely Active Ulcerative Colitis | 2 |
| Newport Native MD, Inc | Bronchiectasis, Interstitial Lung Diseases | 2 |
| Newport Native MD, Inc. | COPD, Hypersensitivity Pneumonitis, Interstitial Lung Disease | 2 |
| Newport Therapeutics | Degenerative Disc Disease, Osteoarthritis, Knee | 2 |
| Radin Cardiovascular Medical Group | Heart Failure, Heart Failure With Mildly Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction | 2 |
| USC Norris Cancer Center | Adenocarcinoma, Pancreatic Ductal, Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer | 2 |
| Autobahn | Major Depressive Disorder | 1 |
| CREST | Open Angle Glaucoma | 1 |
| CREST-XT | Open-angle Glaucoma (OAG) | 1 |
| Clinical Study Site | Non-Small Cell Lung Cancer | 1 |
| Crinetics Study Site | Neuroendocrine Neoplasm, Neuroendocrine Tumors, SST2-positive Neuroendocrine Neoplasms | 1 |
| CureDuchenne | Becker Muscular Dystrophy, Duchenne Muscular Dystrophy | 1 |
Active & Upcoming Studies in Newport Beach (2026)
Recruiting trials in Newport Beach grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (101 active studies)
- A Phase 2 Trial of 61Cu-NU101 PET/CT Compared Against Current Standard-of-care 18F-piflufolastat (Pylarify®) PET/CT. · Phase 2 · Hoag Memorial Hospital Presbyterian
- Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial · Phase 2 · City of Hope Medical Center
Eye & vision (13 active studies)
- A Clinical Study Evaluating Licaminlimab for Dry Eye Disease · Phase 2, Phase 3 · Oculis
- SYSTANE® PRO vs. MIEBO™ in Dry Eye Disease · Phase 4 · Indiana University
Cardiovascular (11 active studies)
- Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention · Phase 4 · Duke University
- Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity · Phase 3 · Amgen
Neurology & pain (7 active studies)
Diabetes & metabolic (5 active studies)
- A U.S. Pilot Human Investigation of RadiofrEquency Vapor Ablation System to Evaluate Safety, TOleRability, and Effectiveness for Proximal Intestinal Mucosal Ablation in Patients With Type 2 Diabetes Mellitus (RESTORE-1 Study) · Aqua Medical, Inc.
- Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity · Phase 3 · Amgen
Vaccines (1 active study)
- Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia. · Phase 2 · Vasomune Therapeutics, Inc.
Common conditions studied in Newport Beach
- Breast Cancer (10 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Breast Neoplasms (6 active studies). Recruiting Breast Neoplasms studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Advanced Solid Tumor (5 active studies). Recruiting Advanced Solid Tumor studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Cancer (5 active studies). Recruiting Cancer studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Head and Neck Squamous Cell Carcinoma (5 active studies). Recruiting Head and Neck Squamous Cell Carcinoma studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Non-small Cell Lung Cancer (5 active studies). Lung cancer research focuses on targeted therapies for specific mutations such as EGFR, ALK, and KRAS, alongside immunotherapy regimens.
Leading research sponsors in Newport Beach
- AstraZeneca
- National Cancer Institute (NCI)
- SWOG Cancer Research Network
- City of Hope Medical Center
- Hoffmann-La Roche
Local regulations and guidelines
Clinical trials in California are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. In addition, California-specific protections such as the California Consumer Privacy Act (CCPA) and the Confidentiality of Medical Information Act (CMIA) impose stringent data-privacy requirements on research involving California residents.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Newport Beach. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Newport Beach
Hipa.ai aggregates every recruiting study in Newport Beach from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Newport Beach?
There are approximately 215 recruiting clinical trials in Newport Beach, California listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Newport Beach pay participants?
Most recruiting trials in Newport Beach compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Newport Beach?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Newport Beach?
The most common conditions under active study in Newport Beach include Breast Cancer (10), Breast Neoplasms (6), Advanced Solid Tumor (5), Cancer (5), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Newport Beach?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Newport Beach on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Newport Beach?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Newport Beach?
Recruiting research sites in Newport Beach include Hoag Memorial Hospital Presbyterian, USC Norris Oncology/Hematology-Newport Beach, Hoag Memorial Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Newport Beach right now?
The largest active categories in Newport Beach are Cancer & tumors (101), Eye & vision (13), Cardiovascular (11). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.