A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies

Part of paid clinical trials in Duarte, California.

Sponsor
SEED Therapeutics, Inc.
Study ID
NCT07197554
Phase
PHASE1
Status
Recruiting
Apply to this trial

Conditions

  • Advanced Solid Tumors
  • Biliary Tract Cancer (BTC)
  • Ewing Sarcoma
  • Hepatocellular Carcinoma (HCC)

Eligibility Criteria

Sex
ALL
Age
16 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • ST-01156 — DRUG
    ST-01156 is an orally administered degrader of RBM39, a protein frequently upregulated in cancer

Study Details

A Phase 1/1B Study of ST-01156 in Patients with Advanced Solid Malignancies

Key Dates

Start date
Dec 1, 2025
Status verified
May 2026
Primary completion
Dec 31, 2029
Completion
Dec 31, 2029

Study Design

Enrollment
171 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Dose Escalation
    ST-01156, administered orally once daily for 5 consecutive days followed by 2 days without study drug administration every 7 days

Primary Outcome Measure

Part 1: Dose Escalation [ Time Frame: First 28 days of treatment ]

Central Contacts

Locations (6)

FacilityCityStateZIPSite coordinators
The City of Hope National Medical CenterDuarteCalifornia91010
Kathryn Zurcher
[email protected]
626-218-3029
Daneng Li (PRINCIPAL_INVESTIGATOR)
Hoag Memorial HospitalNewport BeachCalifornia92263
Holland Orndorff
[email protected]
949-764-7110
Alain Mita (PRINCIPAL_INVESTIGATOR)
Dana Farber Cancer InstituteBostonMassachusetts02215
Suzanne George
[email protected]
877-338-7425
Suzanne George, MD (PRINCIPAL_INVESTIGATOR)
Mass General Brigham Cancer InstituteBostonMassachusetts02114
Kristina Goodwin
[email protected]
617-643-6256
Gregory Cote (PRINCIPAL_INVESTIGATOR)
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065
Pri Wartanian
[email protected]
210-685-2159
Robert Maki (PRINCIPAL_INVESTIGATOR)
The University of Texas MD Anderson Cancer CenterHoustonTexas77030
Kofi Effa Ababio
[email protected]
346-725-3989
Jordi Rodon Ahnert (PRINCIPAL_INVESTIGATOR)

Find similar trials in Duarte, CA

By research site
The City of Hope National Medical Center· Duarte, CAHoag Memorial Hospital· Newport Beach, CADana Farber Cancer Institute· Boston, MAMass General Brigham Cancer Institute· Boston, MAMemorial Sloan Kettering Cancer Center· New York, NYThe University of Texas MD Anderson Cancer Center· Houston, TX

Related Studies