SLV-154 Treatment of Metastatic Solid Tumors

Part of paid clinical trials in Newport Beach, California.

Sponsor
Solve Therapeutics
Study ID
NCT06771219
Phase
PHASE1
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • SLV-154 — DRUG
    SLV-154

Study Details

This is a Phase 1 dose-escalation study evaluating the safety, pharmacokinetics, pharmacodynamics, immunogenicity, and efficacy of SLV-154 across a range of dose levels when administered to subjects with metastatic solid tumors.

Key Dates

Start date
May 14, 2025
Status verified
Jan 2026
Primary completion
Jan 31, 2027
Completion
Apr 30, 2027

Study Design

Enrollment
70 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Dose Level 1
    0.75 mg/kg
  • Experimental: Dose Level 2
    1.5 mg/kg
  • Experimental: Dose Level 3
    3.0 mg/kg
  • Experimental: Dose Level 4
    5.0 mg/kg
  • Experimental: Dose Level 5
    7.5 mg/kg
  • Experimental: Dose Level 6
    10.0 mg/kg
  • Experimental: Dose Level 7
    12.5 mg/kg
  • Experimental: Dose Level 8
    15.0 mg/kg

Primary Outcome Measure

MTD and/or RDR [ Time Frame: Through the duration of treatment, up to approximately 18 months ]

Central Contacts

Locations (9)

FacilityCityStateZIPSite coordinators
Hoag Memorial Hospital PresbyterianNewport BeachCalifornia92663
Cindy Do, BSN, RN
[email protected]
949-764-4624
Washington UniversitySt LouisMissouri63110
Sara Mitchum
[email protected]
314-273-8602
Astera Cancer CareEast BrunswickNew Jersey08816
Percy Yeung
[email protected]
732-387-3378
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065
Roisin O'Cearbhaill, MD
[email protected]
646-888-4227
MD Anderson Cancer CenterHoustonTexas77030
Rabia Khan
[email protected]
713-563-4667
Oncology ConsultantsHoustonTexas77030
Julio Peguero, MD
[email protected]
713-600-0900
Mays Cancer Center; University of Texas Health San AntonioSan AntonioTexas78229
Daruka Mahadevan, MD
[email protected]
210-450-1000
Daruka Mahadevan (PRINCIPAL_INVESTIGATOR)
University of Washington / Fred Hutchinson Cancer CenterSeattleWashington98109
Phase 1 Clinical Trials
[email protected]
206-606-7551
Northwest Medical Specialties, PLLCTacomaWashington98405
CarrieAnn Brown
[email protected]
253-428-8700
Kiersten Peart
[email protected]
253-428-8700

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