GI oncology Clinical Trials in New York, NY

As of June 2026, 148 paid clinical trials are recruiting for GI oncology in New York, New York. GI oncology trials cover colorectal, pancreatic, gastric, esophageal, liver, and biliary cancers — testing chemotherapy combinations, targeted agents, and immunotherapy for microsatellite-instability-high tumors. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

Filter results

Filter results

State

City

Facility

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

148 clinical trials for GI oncology

·Clear filters·↓ Download CSV

Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

for Non-small Cell Lung Cancer

18 locations incl. Duarte

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06218914·Phase 1·Recruiting

Apply to this trial

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

for Advanced Solid Tumor

13 locations incl. Duarte

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06172478·Phase 2·Recruiting

Apply to this trial

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

for Endometrial Cancer

17 locations incl. Birmingham

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT06293898·Phase 1·Recruiting

Apply to this trial

A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer

for Esophageal Cancer

10 locations incl. Boston

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06123338·Phase 2·Recruiting

Apply to this trial

The LINFU® U.S. Registry for the Detection of Asymptomatic Pancreatic Ductal Adenocarcinoma

for Pancreatic Adenocarcinoma

1 location in New York

Sponsor: Adenocyte, LLC

Sex: All·Age: 18 - 90

Code: NCT06157671·Enrolling By Invitation

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

for Non-Small Cell Lung Cancer (NSCLC)

Drug: daraxonrasib

21 locations incl. Duarte

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06128551·Phase 1, Phase 2·Recruiting

Apply to this trial

A Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) Guided by Magnetic Resonance Imaging (MRI) in People With Liver Metastasis From Colorectal Cancer

for Colorectal Cancer

7 locations incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06130280·Phase 2·Recruiting

Apply to this trial

A Study of Mental Health Care in People With Cancer

for Breast Cancer

1 location in New York

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 65+

Code: NCT06037954·Recruiting

Apply to this trial

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

for Non Small Cell Lung Cancer

24 locations incl. Beverly Hills

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT05983432·Phase 1·Recruiting

Apply to this trial

A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue

for Invasive Ductal Breast Carcinoma

7 locations incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT05837767·Recruiting

Apply to this trial

A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

for Non-small Cell Lung Cancer

18 locations incl. Gilbert

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05877599·Phase 1·Recruiting

Apply to this trial

Study of AZD5863 in Adult Participants With Advanced or Metastatic Solid Tumors

for Gastric Cancer

3 locations incl. Jacksonville

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06005493·Phase 1, Phase 2·Recruiting

Apply to this trial

Colonoscopy vs Stool Testing for Older Adults With Colon Polyps

for Colorectal Polyp

18 locations incl. Birmingham

Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All·Age: 65 - 82

Code: NCT05612347·Recruiting

Apply to this trial

FOG-001 in Locally Advanced or Metastatic Solid Tumors

for Cancer

31 locations incl. Phoenix

Sponsor: Parabilis Medicines, Inc.

Sex: All·Age: 18+

Code: NCT05919264·Phase 1, Phase 2·Recruiting

Apply to this trial

The Radiation Oncology-Biology Integration Network (ROBIN) Molecular Characterization Trial (MCT) of Standard Short Course Radiotherapy for Rectal Cancer

for Rectal Cancer

5 locations incl. Chicago

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18 - 90

Code: NCT05943210·Recruiting

Apply to this trial

Phase II Trial of Lung Chemoemobolization

for Lung Non-Small Cell Carcinoma

2 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05672108·Phase 2·Recruiting

Apply to this trial

A Study of NALIRIFOX in Combination With Radiation Therapy in People With Pancreatic Ductal Adenocarcinoma (PDAC)

for Pancreatic Ductal Adenocarcinoma

7 locations incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT05851924·Phase 2·Recruiting

Apply to this trial

A Study on the Effects of Exercise on Side Effects From Treatment for Gastrointestinal Cancers

for Gastrointestinal Cancer

8 locations incl. Hartford

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT05789485·Phase 2·Recruiting

Apply to this trial

Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer

for Hepatocellular Carcinoma

10 locations incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05775159·Phase 2·Recruiting

Apply to this trial

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

for Non-small Cell Lung Cancer

10 locations incl. Gilbert

Sponsor: Institut de Recherches Internationales Servier

Sex: All·Age: 18+

Code: NCT05786924·Phase 1, Phase 2·Recruiting

Apply to this trial

EUS RFA for Treatment of Pancreatic Ductal Adenocarcinoma (PDAC)

for Pancreatic Cancer

1 location in New York

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT05723107·Phase 1·Recruiting

Apply to this trial

A Study of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma

for Hepatocellular Carcinoma

21 locations incl. Birmingham

Sponsor: Tvardi Therapeutics, Incorporated

Sex: All·Age: 18+

Code: NCT05440708·Phase 1, Phase 2·Recruiting

Apply to this trial

Community Health Workers United to Reduce Colorectal Cancer and Cardiovascular Disease Among People at Higher Risk

for Colorectal Cancer

1 location in New York

Sponsor: Columbia University

Sex: All·Age: 45+·Accepts healthy volunteers

Code: NCT05174286·Recruiting

Apply to this trial

Modulation of the Gut Microbiome With Pembrolizumab Following Chemotherapy in Resectable Pancreatic Cancer

for Pancreatic Cancer

1 location in New York

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 19+

Code: NCT05462496·Phase 2·Recruiting

Apply to this trial

Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia

for Barretts Esophagus With Dysplasia

23 locations incl. Los Angeles

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 89

Code: NCT05753748·Recruiting

Apply to this trial

Novel Combinations in Participants With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

for Gastric Cancer

11 locations incl. Los Angeles

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05702229·Phase 2·Recruiting

Apply to this trial

A Study of Tucatinib and Trastuzumab in People With Rectal Cancer

for Adenocarcinoma of the Rectum

7 locations incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT05672524·Phase 2·Recruiting

Apply to this trial

BAL0891 in Patients With Advanced Solid Tumors or Relapsed or Refractory Acute Myeloid Leukemia

for Advanced Solid Tumor

9 locations incl. New Haven

Sponsor: SillaJen, Inc.

Sex: All·Age: 18+

Code: NCT05768932·Phase 1·Recruiting

Apply to this trial

A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

for Colorectal Neoplasms

128 locations incl. Glendale

Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All·Age: 18+

Code: NCT05253651·Phase 3·Recruiting

Apply to this trial

Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance

for Barrett Esophagus

14 locations incl. Gilbert

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 89

Code: NCT05530343·Recruiting

Apply to this trial

A Study of the Possible Effects of Medication on Young Onset Colorectal Cancer (YOCRC)

for Colorectal Cancer

1 location in New York

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18 - 49·Accepts healthy volunteers

Code: NCT05568420·Recruiting

Apply to this trial

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

for Acute Lymphoblastic Leukemia

746 locations incl. Anchorage

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 40 - 75·Accepts healthy volunteers

Code: NCT05334069·Recruiting

Apply to this trial

Study of Nab-Paclitaxel and Gemcitabine With or Without SBP-101 in Pancreatic Cancer

for Pancreatic Cancer Metastatic

14 locations incl. Hot Springs

Sponsor: Panbela Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05254171·Phase 2, Phase 3·Recruiting

Apply to this trial

Comprehensive Outcomes for After Cancer Health

for Ovarian Cancer

7 locations incl. Gainesville

Sponsor: Pack Health

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05349227·Recruiting

Apply to this trial

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

for Mesothelioma

25 locations incl. Phoenix

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT05245500·Phase 1·Recruiting

Apply to this trial

A Study of ASP2138 Given by Itself or Given With Other Cancer Treatments in Adults With Stomach Cancer, Gastroesophageal Junction Cancer, or Pancreatic Cancer

for Gastric Adenocarcinoma

13 locations incl. Orange

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 18+

Code: NCT05365581·Phase 1·Recruiting

Apply to this trial

A Phase I-II Study to Test the Safety and Efficacy of PD1 (AB122) and Adenosine Receptor (AB928) Antagonists With Chemotherapy After Short-Course Radiation for Rectal Cancer.

for Rectal Cancer

3 locations incl. New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18 - 90

Code: NCT05024097·Phase 2·Recruiting

Apply to this trial

Stimulation With Bethanechol in Combination With Gemcitabine and Nab-paclitaxel in Pancreatic Adenocarcinoma

for Pancreas Cancer

1 location in New York

Sponsor: Susan E. Bates

Sex: All·Age: 18+

Code: NCT05241249·Phase 2·Recruiting

Apply to this trial

Developing New Educational Materials About Genetic Testing for a Diverse Group of Cancer Patients

for Educational Materials for Genetic Testing

4 locations incl. Brooklyn

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT04751435·Recruiting

Apply to this trial

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

for Colorectal Carcinoma

21 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 12 Months - 30

Code: NCT04851119·Phase 1, Phase 2·Recruiting

Apply to this trial

Conditions in GI oncology (New York, NY)

Pancreatic cancer· 53 Colorectal cancer· 52 Gastric cancer· 24 Esophageal cancer· 24 Biliary tract cancer· 13 Rectal cancer· 10 Liver cancer· 10 Gastroesophageal junction cancer· 8 Colon cancer· 6 Gastrointestinal cancer· 5 Metastatic colorectal cancer· 3