A Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) Guided by Magnetic Resonance Imaging (MRI) in People With Liver Metastasis From Colorectal Cancer

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT06130280
Phase
PHASE2
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • MR Guided Single Fraction Stereotactic Body Radiation Therapy (SBRT) — RADIATION
    40Gy single fraction treatment on Elekta Unity using Gd-EOB-DTPA-enhanced MR for image guidance.

Study Details

The researchers are doing this study to see if one session of high-dose contrast-enhanced MRI-guided SBRT (stereotactic body radiation therapy) is effective for colorectal cancer that has spread to the liver. The researchers will evaluate how well the study treatment can prevent the liver metastasis from growing and spreading. In addition, they will see whether it causes any side effects and whether there are any characteristics of the research MRI images that can predict response to treatment.

Key Dates

Start date
Nov 8, 2023
Status verified
Feb 2026
Primary completion
Nov 30, 2026
Completion
Nov 30, 2026

Study Design

Enrollment
32 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: MR Guided Single Fraction Stereotactic Body Radiation Therapy (SBRT)
    Participants will undergo simulation including Gd-EOB-DTPAenhanced MR and planning using minimal margins. Ten days later (+/- 3 days) participants will receive 40Gy single fraction treatment on Elekta Unity using Gd-EOB-DTPA-enhanced MR for image guidance and on-line adaptive replanning.

Primary Outcome Measure

Local control rate CRC liver metastasis [ Time Frame: 1 year ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)Basking RidgeNew Jersey07920
Marsha Reyngold, MD, PhD
631-623-4267
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)MiddletownNew Jersey07748
Marsha Reyngold, MD, PhD
631-623-4267
Memorial Sloan Kettering Bergen (Limited Protocol Activities)MontvaleNew Jersey07645
Marsha Reyngold, MD, PhD
631-623-4267
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)CommackNew York11725
Marsha Reyngold, MD, PhD
631-623-4267
Memorial Sloan Kettering Westchester (Limited Protocol Activities)HarrisonNew York10604
Marsha Reyngold, MD, PhD
631-623-4267
Memorial Sloan Kettering Cancer Center (All protocol activities)New YorkNew York10065
Marsha Reyngold, MD, PhD
631-623-4267
Memorial Sloan Kettering Nassau (Limited Protocol Activities)Rockville CentreNew York11553
Marsha Reyngold, MD, PhD
631-623-4267

Find similar trials in Basking Ridge, NJ

By condition
Colorectal cancer
By specialty
OncologyGI oncology
By research site
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (Limited Protocol Activities)· Middletown, NJMemorial Sloan Kettering Bergen (Limited Protocol Activities)· Montvale, NJMemorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)· Commack, NYMemorial Sloan Kettering Westchester (Limited Protocol Activities)· Harrison, NYMemorial Sloan Kettering Cancer Center (All protocol activities)· New York, NY

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