Paid Clinical Trials in North Carolina

North Carolina has 2,944 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,944 clinical trials

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ZEN003694 and Enzalutamide Versus Enzalutamide Monotherapy in Metastatic Castration-Resistant Prostate Cancer

for Metastatic Castration-Resistant Prostate Cancer

16 locations incl. Los Angeles

Sponsor: Zenith Epigenetics

Sex: Male·Age: 18+

Code: NCT04986423·Phase 2·Recruiting

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SPIROMICS Study of Early COPD Progression (SOURCE)

for COPD, Early-Onset

14 locations incl. Birmingham

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 30 - 55·Accepts healthy volunteers

Code: NCT05033990·Recruiting

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ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

for Bladder Carcinoma

33 locations incl. Birmingham

Sponsor: Guardant Health, Inc.

Sex: All·Age: 18+

Code: NCT05059444·Recruiting

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A Feasibility Study Utilizing Immune Recall to Increase Response to Checkpoint Therapy

for Melanoma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT05077137·Phase 1·Recruiting

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Long-term Safety and Efficacy of Odevixibat in Patients With Alagille Syndrome

for Alagille Syndrome

18 locations incl. San Diego

Sponsor: Albireo, an Ipsen Company

Sex: All·Age: All ages

Code: NCT05035030·Phase 3·Recruiting

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Bempedoic Acid Pregnancy Surveillance Program

for Pregnancy

Drug: Bempedoic acid

1 location in Morrisville

Sponsor: Esperion Therapeutics, Inc.

Sex: Female·Age: 18+

Code: NCT05103254·Recruiting

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High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers

for Metastatic Prostate Cancer

17 locations incl. Aurora

Sponsor: VA Office of Research and Development

Sex: Male·Age: 18+

Code: NCT05011383·Phase 2·Recruiting

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WAKIX® (Pitolisant) Pregnancy Registry

for Pregnancy Related

1 location in Morrisville

Sponsor: Harmony Biosciences Management, Inc.

Sex: Female·Age: All ages

Code: NCT05536011·Recruiting

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Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury

for Cannabis

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 25 - 59·Accepts healthy volunteers

Code: NCT04810858·Recruiting

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A Phase 2a Study of IV BCV in Subjects With Adenovirus Infection

for Adenovirus Infections

11 locations incl. Los Angeles

Sponsor: SymBio Pharmaceuticals

Sex: All·Age: 2 Months+

Code: NCT04706923·Phase 2·Recruiting

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Retinal Microanatomy in Retinopathy of Prematurity (BabySTEPS2)

for Retinopathy of Prematurity

2 locations incl. Durham

Sponsor: Duke University

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04995341·Recruiting

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Selatogrel Outcome Study in Suspected Acute Myocardial Infarction

for Acute Myocardial Infarction

Drug: Selatogrel

81 locations incl. Alexander City

Sponsor: Viatris Innovation GmbH

Sex: All·Age: 18+

Code: NCT04957719·Phase 3·Enrolling By Invitation

Study of Sparsentan Treatment in Pediatrics With Proteinuric Glomerular Diseases

for Focal Segmental Glomerulosclerosis

Drug: Sparsentan

23 locations incl. Los Angeles

Sponsor: Travere Therapeutics, Inc.

Sex: All·Age: 1 - 17

Code: NCT05003986·Phase 2·Recruiting

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Extension Study to Evaluate Safety and Tolerability of Oral Dersimelagon (MT-7117) in Subjects With Erythropoietic Protoporphyria (EPP) or X-Linked Protoporphyria (XLP)

for EPP

15 locations incl. Huntington Beach

Sponsor: Tanabe Pharma America, Inc.

Sex: All·Age: 12 - 75

Code: NCT05005975·Phase 3·Recruiting

Apply to this trial

IT Matters: The Erectile Restoration Registry

for Erectile Dysfunction

21 locations incl. Los Angeles

Sponsor: Boston Scientific Corporation

Sex: Male·Age: 18+·Accepts healthy volunteers

Code: NCT04200937·Enrolling By Invitation

Modified VR-CAP and Acalabrutinib as First Line Therapy for the Treatment of Transplant-Eligible Patients With Mantle Cell Lymphoma

for Mantle Cell Lymphoma

7 locations incl. New Orleans

Sponsor: Academic and Community Cancer Research United

Sex: All·Age: 18 - 75

Code: NCT04626791·Phase 2·Recruiting

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GI-101/GI-101A as a Single Agent or in Combination With Pembrolizumab or Lenvatinib in Advanced Solid Tumors

for Advanced Solid Tumor

2 locations incl. New York

Sponsor: GI Innovation, Inc.

Sex: All·Age: 18+

Code: NCT04977453·Phase 1, Phase 2·Recruiting

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Dyad Plus Effectiveness/Feasibility

for Weight Loss

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 13 - 65

Code: NCT04036331·Recruiting

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Study to Evaluate Pregnancy Outcomes in Risankizumab Exposed Pregnancies Relative to Those Non-risankizumab Exposed Pregnancies in Women With FDA Approved Indications

for Plaque Psoriasis, Psoriatic Arthritis, Crohn's Disease, or Other Conditions for Which Risankizumab is an FDA-approved Treatment

Drug: Risankizumab

2 locations incl. Morrisville

Sponsor: AbbVie

Sex: Female·Age: All ages

Code: NCT04846959·Recruiting

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A Study of 177Lu-FAP-2286 in Advanced Solid Tumors

for Solid Tumor

20 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT04939610·Phase 1, Phase 2·Recruiting

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Prospective Evaluation of Complex Adult Spinal Deformity (CAD) Treated With Minimally Invasive Surgery

for Adult Spinal Deformity

12 locations incl. Phoenix

Sponsor: International Spine Study Group Foundation

Sex: All·Age: 18+

Code: NCT04885244·Recruiting

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EFS of the CardioMech MVRS

for Mitral Regurgitation

12 locations incl. Thousand Oaks

Sponsor: CardioMech AS

Sex: All·Age: 18+

Code: NCT04820764·Recruiting

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A Study to Evaluate the Safety and Tolerability of Dapirolizumab Pegol in Study Participants With Systemic Lupus Erythematosus

for Systemic Lupus Erythematosus

29 locations incl. Birmingham

Sponsor: UCB Biopharma SRL

Sex: All·Age: 16+

Code: NCT04976322·Phase 3·Enrolling By Invitation

The GUARDIAN Trial

for Blood Pressure

6 locations incl. Omaha

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 45+

Code: NCT04884802·Recruiting

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FaCT Trial (Facilitated Cascade Testing Trial)

for BRCA1 Mutation

3 locations incl. New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04613440·Recruiting

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A Study to Evaluate the Benefits and Risks of Conversion of Existing Adolescent Kidney Transplant Recipients Aged 12 to <18 Years to a Belatacept-based Immunosuppressive Regimen as Compared to Continuation of a Calcineurin Inhibitor-based Regimen, and Their Adherence to Immunosuppressive Medications

for Renal Allograft Recipients

15 locations incl. Birmingham

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 12 - 17

Code: NCT04877288·Phase 3·Recruiting

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Registry of Arthrex Hand and Wrist Products

for Ulnar/Radial Collateral Ligament Reconstruction

5 locations incl. Phoenix

Sponsor: Arthrex, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05046600·Recruiting

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Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies.

for CLL/SLL

4 locations incl. Durham

Sponsor: Newave Pharmaceutical Inc

Sex: All·Age: 18+

Code: NCT04775745·Phase 1·Recruiting

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A Study of Nipocalimab Administered to Adults With Generalized Myasthenia Gravis

for Myasthenia Gravis

Drug: Nipocalimab

24 locations incl. Paradise Valley

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT04951622·Phase 3·Recruiting

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Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease

for Interstitial Lung Disease

6 locations incl. San Francisco

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 4+

Code: NCT04925375·Phase 2·Recruiting

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A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

for Central Nervous System Nongerminomatous Germ Cell Tumor

149 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 3 - 29

Code: NCT04684368·Phase 2·Recruiting

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Valved Graft PMCF Study

for Aortic Valve Disease

5 locations incl. Birmingham

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT04754217·Recruiting

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Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma

for Glioma, Malignant

1 location in Durham

Sponsor: Darell Bigner

Sex: All·Age: 18+

Code: NCT04547777·Phase 1·Recruiting

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Prospective, Multicenter, Case-Control Analysis of the VersaTie Posterior Fixation System to Prevent Proximal Junctional Failure in Long Posterior Spinal Fusion Constructs for Adult Patients

for Adult Spinal Deformity

9 locations incl. Phoenix

Sponsor: International Spine Study Group Foundation

Sex: All·Age: 18+

Code: NCT04888104·Recruiting

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CureDuchenne Link®: A Resource for Research

for Duchenne Muscular Dystrophy

10 locations incl. Little Rock

Sponsor: CureDuchenne

Sex: All·Age: 4 Weeks+

Code: NCT04972604·Recruiting

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G7 Acetabular System With Vivacit-E or Longevity Liner PMCF Study

for Total Hip Arthroplasty

6 locations incl. Denver

Sponsor: Zimmer Biomet

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04754087·Recruiting

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A Pilot Study of Revian Red All LED Cap as a Novel Treatment for Central Centrifugal Cicatricial Alopecia

for Central Centrifugal Cicatricial Alopecia

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18 - 75

Code: NCT04764331·Recruiting

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Testing the Addition of Abemaciclib to Olaparib for Women With Recurrent Ovarian Cancer

for Recurrent Ovarian High Grade Serous Adenocarcinoma

27 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT04633239·Phase 1·Recruiting

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Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer

for Prostate Cancer

20 locations incl. Long Beach

Sponsor: VA Office of Research and Development

Sex: Male·Age: 18+

Code: NCT04787744·Phase 2, Phase 3·Recruiting

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A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic Migraine

for Chronic Migraine in Children

22 locations incl. New Haven

Sponsor: H. Lundbeck A/S

Sex: All·Age: 12 - 17

Code: NCT04965675·Phase 3·Recruiting

Apply to this trial