Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,602 clinical trials

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Long-Term Safety and Efficacy Evaluation of Amlitelimab in Participants of Previous Amlitelimab Moderate to Severe Atopic Dermatitis Clinical Trials

for Dermatitis Atopic

Drug: Amlitelimab

96 locations incl. Birmingham

Sponsor: Sanofi

Sex: All·Age: 12+

Code: NCT05492578·Phase 2, Phase 3·Enrolling By Invitation

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

for Acute Lymphoblastic Leukemia

746 locations incl. Anchorage

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 40 - 75·Accepts healthy volunteers

Code: NCT05334069·Recruiting

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A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Patients With Multiple Myeloma That is Resistant to Current Standard of Care Treatments

for Multiple Myeloma

Drug: Linvoseltamab

13 locations incl. La Jolla

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05137054·Phase 1·Recruiting

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A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)

for Obstructive Hypertrophic Cardiomyopathy

Drug: Mavacamten

62 locations incl. Anchorage

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT05489705·Recruiting

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MiSight 1 Day Safety Post-Approval Study

for Myopia

47 locations incl. Gilbert

Sponsor: CooperVision, Inc.

Sex: All·Age: 8 - 12·Accepts healthy volunteers

Code: NCT05285527·Recruiting

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A Study of XMT-1660 in Participants With Solid Tumors

for Triple Negative Breast Cancer

26 locations incl. Phoenix

Sponsor: Mersana Therapeutics

Sex: All·Age: 18+

Code: NCT05377996·Phase 1·Recruiting

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North American Prodromal Synucleinopathy Consortium Stage 2

for REM Sleep Behavior Disorder

8 locations incl. Los Angeles

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05826457·Enrolling By Invitation

Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

for Breast Cancer

51 locations incl. Mobile

Sponsor: Greenwich LifeSciences, Inc.

Sex: All·Age: 18 - 100

Code: NCT05232916·Phase 3·Recruiting

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Exercise to Enhance Cardiovascular Health Among Black Prostate Cancer Patients With Androgen Deprivation Therapy

for Androgen Deprivation Therapy

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Male·Age: 18+

Code: NCT05327465·Recruiting

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Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V

for Lupus Nephritis

26 locations incl. Phoenix

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT05268289·Phase 2·Recruiting

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Immuno-PRISM (PRecision Intervention Smoldering Myeloma)

for High-risk Smoldering Multiple Myeloma

3 locations incl. Denver

Sponsor: Irene Ghobrial, MD

Sex: All·Age: 18+

Code: NCT05469893·Phase 2·Recruiting

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Neural Mechanisms of Spatial Representations Beyond the Self

for Epilepsy Intractable

1 location in Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 18 - 70

Code: NCT05406349·Recruiting

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Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)

for Cardiac Arrest, Out-Of-Hospital

50 locations incl. Birmingham

Sponsor: University of Michigan

Sex: All·Age: 2 Days - 17

Code: NCT05376267·Recruiting

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Modulating Exercise Dosage to Improve Concussion Recovery

for Concussion, Brain

3 locations incl. Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 13 - 18

Code: NCT05434130·Phase 2·Recruiting

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Video Education With Result Dependent dIsclosure

for Genetic Testing

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT05225428·Recruiting

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Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

for Embryonal Rhabdomyosarcoma

165 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT05304585·Phase 3·Recruiting

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First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors

for Gastrointestinal Neoplasms

8 locations incl. Miami

Sponsor: IDRX, Inc., a wholly owned subsidiary of GSK, LLC

Sex: All·Age: 18+

Code: NCT05489237·Phase 1·Recruiting

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Rett Syndrome Registry

for Rett Syndrome

18 locations incl. Birmingham

Sponsor: International Rett Syndrome Foundation

Sex: All·Age: 0 - 99

Code: NCT05432349·Recruiting

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LYL273 for Patients With Relapsed or Refractory mCRC

for Colorectal Cancer

4 locations incl. Duarte

Sponsor: Lyell Immunopharma, Inc.

Sex: All·Age: 18+

Code: NCT05319314·Phase 1, Phase 2·Recruiting

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Genetic Risk Stratification of Pediatric Skin Lesions

for Skin Lesion

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 0 - 20

Code: NCT05418959·Phase 1·Enrolling By Invitation

Cerebrospinal Fluid Biomarkers of Myotonic Dystrophy

for Myotonic Dystrophy Type 1

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06075693·Recruiting

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Clinical Trial to Evaluate the Safety and Efficacy of DWN12088 in Patients With IPF

for Idiopathic Pulmonary Fibrosis

20 locations incl. Mesa

Sponsor: Daewoong Pharmaceutical Co. LTD.

Sex: All·Age: 40+

Code: NCT05389215·Phase 2·Recruiting

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Brain Stimulation for Severe Depression

for Depression Severe

2 locations incl. Boston

Sponsor: Inner Cosmos Inc

Sex: All·Age: 21 - 80

Code: NCT05393622·Recruiting

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Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy

for Peripartum Cardiomyopathy, Postpartum

64 locations incl. Birmingham

Sponsor: Dennis M. McNamara, MD, MS

Sex: Female·Age: 18+

Code: NCT05180773·Phase 4·Recruiting

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Dropless Pars Plana Vitrectomy Study

for Rhegmatogenous Retinal Detachment

1 location in Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT05331664·Phase 4·Recruiting

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Pre-emptive Prevention for Patients at High Risk for Hospital-onset Clostridioides Difficile

for C. Difficile

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05389904·Recruiting

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ET140203 T Cells in Pediatric Subjects With Hepatoblastoma, HCN-NOS, or Hepatocellular Carcinoma

for Hepatoblastoma

2 locations incl. San Francisco

Sponsor: Eureka Therapeutics Inc.

Sex: All·Age: 1 - 21

Code: NCT04634357·Phase 1, Phase 2·Recruiting

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Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier

for Pulmonary Nodule, Solitary

22 locations incl. Hartford

Sponsor: Veracyte, Inc.

Sex: All·Age: 29 - 85

Code: NCT06426628·Recruiting

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Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness

for Psychosis

1 location in Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT04940663·Recruiting

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Testing the Safety and Efficacy of the Addition of a New Anti-cancer Drug, ZEN003694, to Chemotherapy Treatment (Cisplatin and Etoposide or Carboplatin and Paclitaxel) for Adult and Pediatric Patients (12-17 Years) With NUT Carcinoma

for Advanced NUT Carcinoma

5 locations incl. Los Angeles

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12+

Code: NCT05019716·Phase 1, Phase 2·Recruiting

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A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies

for Leukemia, Acute Myeloid

7 locations incl. Denver

Sponsor: MacroGenics

Sex: All·Age: 18+

Code: NCT05362773·Phase 1·Recruiting

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A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas

for LGLL - Large Granular Lymphocytic Leukemia

15 locations incl. Birmingham

Sponsor: Dren Bio

Sex: All·Age: 18+

Code: NCT05475925·Phase 1, Phase 2·Recruiting

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A Study of LBP-EC01 in the Treatment of Acute Uncomplicated UTI Caused by Drug Resistant E. Coli (ELIMINATE Trial)

for Urinary Tract Infections

17 locations incl. Fresno

Sponsor: Locus Biosciences

Sex: Female·Age: 18 - 75

Code: NCT05488340·Phase 2·Recruiting

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ORACLE: A Long-term Follow-up Study to Evaluate the Safety of GT005 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration Treated in a Gyroscope-sponsored Antecedent Study

for Age Related Macular Degeneration (AMD)

22 locations incl. Poway

Sponsor: Gyroscope Therapeutics Limited

Sex: All·Age: 55+

Code: NCT05481827·Phase 2·Enrolling By Invitation

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

for Stage III Colon Cancer

1021 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05174169·Phase 2, Phase 3·Recruiting

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Endoscopic Metabolic and Bariatric Therapies

for Obesity

1 location in Boston

Sponsor: Christopher C. Thompson, MD, MSc

Sex: All·Age: 18 - 80

Code: NCT05725967·Enrolling By Invitation

The FLOTILLA Study: Providing Continued Access to The Study Medicines Encorafenib and Binimetinib for Participants in Prior Clinical Trials

for Solid Tumors

18 locations incl. Phoenix

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT05203172·Phase 4·Recruiting

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A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

for Melanoma

31 locations incl. Fayetteville

Sponsor: Pfizer

Sex: All·Age: 16+

Code: NCT05355701·Phase 1·Recruiting

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An Open-label Extension Study to Evaluate Long-term Efficacy and Safety of Odevixibat in Children With Biliary Atresia

for Biliary Atresia

10 locations incl. Aurora

Sponsor: Albireo, an Ipsen Company

Sex: All·Age: All ages

Code: NCT05426733·Phase 3·Enrolling By Invitation

Abatacept in Immune Checkpoint Inhibitor Myocarditis

for Myocarditis Acute

29 locations incl. Los Angeles

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05335928·Phase 3·Recruiting

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