Paid Clinical Trials in Massachusetts

Massachusetts has 3,584 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 15, 2026.

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3,584 clinical trials

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Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults

for Healthy Adults

1 location in Boston

Sponsor: Metro International Biotech, LLC

Sex: All·Age: 19 - 60·Accepts healthy volunteers

Code: NCT06815991·Phase 1·Recruiting

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A Phase 1/2, First-in-Human Dose Escalation/Expansion Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of a Subretinal Injection of SB-007 in Subjects With Stargardt Disease (STGD1)

for Stargardt Disease

5 locations incl. Aurora

Sponsor: Splice Bio

Sex: All·Age: 12 - 65

Code: NCT06942572·Phase 1, Phase 2·Recruiting

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Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study

for ALS - Amyotrophic Lateral Sclerosis

1 location in Boston

Sponsor: PathMaker Neurosystems Inc.

Sex: All·Age: 18 - 80

Code: NCT06649955·Recruiting

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A Study to Evaluate the Efficacy and Safety of DNTH103 in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CAPTIVATE)

for Chronic Inflammatory Demyelinating Polyneuropathy

31 locations incl. Birmingham

Sponsor: Dianthus Therapeutics

Sex: All·Age: 18 - 75

Code: NCT06858579·Phase 3·Recruiting

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A Preventive Behavioral Intervention for Young Adults With Psychotic Experiences

for Psychotic Disorders

1 location in Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 30

Code: NCT06929442·Recruiting

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A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia Gravis

for Generalized Myasthenia Gravis

Drug: Remibrutinib

24 locations incl. Phoenix

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT06744920·Phase 3·Recruiting

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Early Intervention in High Risk CCUS

for Clonal Cytopenia of Undetermined Significance

1 location in Boston

Sponsor: Lachelle D. Weeks, MD, PhD

Sex: All·Age: 18+

Code: NCT06802146·EARLY_Phase 1·Recruiting

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"Prapela® SVS Incubator Pad for Apnea of Prematurity

for Apnea of Prematurity

2 locations incl. Birmingham

Sponsor: Tufts Medical Center

Sex: All·Age: 0 Days - 3 Months

Code: NCT06374147·Recruiting

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Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

for Castration-Resistant Prostate Carcinoma

107 locations incl. Birmingham

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06632977·Phase 2·Recruiting

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REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

for Aortic Stenosis

71 locations incl. Birmingham

Sponsor: Medtronic Cardiovascular

Sex: All·Age: 18 - 105

Code: NCT06777368·Recruiting

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AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF

for Symptomatic Heart Failure With Preserved Ejection Fraction (HFpEF)

25 locations incl. Fairhope

Sponsor: Cytokinetics

Sex: All·Age: 40 - 85

Code: NCT06793371·Phase 2·Recruiting

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Tibulizumab Systemic Sclerosis Understanding and Response Evaluation (TibuSURE)

for Systemic Sclerosis (SSc)

6 locations incl. La Jolla

Sponsor: Zura Bio Inc

Sex: All·Age: 18 - 75

Code: NCT06843239·Phase 2·Recruiting

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The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia

for Schizophrenia

1 location in Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06386588·Recruiting

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ARC101 in Advanced Solid Tumors

for Advanced Solid Tumor

3 locations incl. Boston

Sponsor: Third Arc Bio

Sex: All·Age: 18+

Code: NCT06672185·Phase 1·Recruiting

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A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy

for Recurrent Childhood Acute Myeloid Leukemia

19 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 1 - 18

Code: NCT06247787·Phase 1·Recruiting

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A Study to Test Whether Spesolimab Helps People With a Skin Condition Called Pyoderma Gangrenosum

for Pyoderma Gangrenosum

19 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06624670·Phase 3·Recruiting

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A Study to Investigate the Safety and Efficacy of KQB365 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies

for KRAS G12C Mutation

11 locations incl. Phoenix

Sponsor: Kumquat Biosciences Inc.

Sex: All·Age: 18+

Code: NCT06720987·Phase 1·Recruiting

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Mental Health, Intellectual and Neurodevelopmental Disorder Detection With Artificial Intelligence Models

for Autism Spectrum Disorder

2 locations incl. Brookline

Sponsor: Psyrin Inc.

Sex: All·Age: 13 - 60

Code: NCT06792175·Enrolling By Invitation

Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

for Major Depressive Disorder

34 locations incl. Birmingham

Sponsor: Syndeio Biosciences, Inc

Sex: All·Age: 18 - 64

Code: NCT06547489·Phase 2·Recruiting

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EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma

for Glioblastoma

32 locations incl. Phoenix

Sponsor: NovoCure GmbH

Sex: All·Age: 18+

Code: NCT06556563·Phase 3·Recruiting

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Combined Anabolic Therapy

for Osteoporosis, Postmenopausal

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 45+·Accepts healthy volunteers

Code: NCT06558188·Phase 4·Recruiting

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Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer

for Extensive-stage Small-cell Lung Cancer

32 locations incl. Tucson

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT06712355·Phase 3·Recruiting

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Measurable Residual Disease Detection Using Tumor-Informed ctDNA Surveillance After Curative-Intent Treatment in HPV-Independent Squamous Cell Carcinoma of the Head and Neck

for Squamous Cell Carcinoma of Head and Neck

1 location in Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 18+

Code: NCT06744296·Recruiting

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Predict the Best Level of Care Placement for Each Child's Behavioral Health Needs - Efficacy Study

for Adolescent Well-Being

1 location in Framingham

Sponsor: Outcome Referrals, Inc.

Sex: All·Age: All ages

Code: NCT06815562·Enrolling By Invitation

Predict the Best Level of Care Placement for Each Child's Behavioral Health Needs - Effectiveness Study

for Adolescent Well-Being

1 location in Framingham

Sponsor: Outcome Referrals, Inc.

Sex: All·Age: All ages

Code: NCT06834763·Enrolling By Invitation

Sensory Outcomes in Active Substance Users

for Post Operative Pain

1 location in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18+

Code: NCT06639438·Recruiting

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Non-Invasive Preeclampsia Screening and Biobank

for Preeclampsia (PE)

21 locations incl. Glendale

Sponsor: Sequenom, Inc.

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06643741·Recruiting

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Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological Manipulation

for Depressive Disorder, Major

1 location in Belmont

Sponsor: Mclean Hospital

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05232032·Phase 2·Recruiting

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Study of Olutasidenib and Temozolomide in HGG

for High Grade Glioma

11 locations incl. Aurora

Sponsor: Rigel Pharmaceuticals

Sex: All·Age: 12 - 39

Code: NCT06161974·Phase 2·Recruiting

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Improving Mental Health Treatment for Individuals in Crisis Interacting With the Criminal-Legal System

for Suicide Risk

1 location in Cambridge

Sponsor: Cambridge Health Alliance

Sex: All·Age: 18 - 100

Code: NCT06564948·Recruiting

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Regulation of Emotion, Sleep Extension, and mTBI

for Mild Traumatic Brain Injury

1 location in North Andover

Sponsor: Merrimack College

Sex: All·Age: 18 - 35

Code: NCT06883006·Phase 1·Recruiting

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Long-term Safety of Nipple Sparing Mastectomy in Women With High Penetrance Breast Cancer Susceptibility Genes in Breast Cancer

for Breast Cancer Surgery

4 locations incl. New Haven

Sponsor: Sir Mortimer B. Davis - Jewish General Hospital

Sex: Female·Age: 18 - 90

Code: NCT06888388·Recruiting

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Determining the Benefits of Exercise on Cardiovascular Risk in PTSD

for PTSD

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07260032·Recruiting

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Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease

for Alzheimer Disease

1 location in Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50 - 80·Accepts healthy volunteers

Code: NCT05904132·Recruiting

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StrokeNet Thrombectomy Endovascular Platform

for Ischemic Stroke

41 locations incl. Birmingham

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06289985·Recruiting

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Vaccine Confidence Study Among Historically Marginalized Racial and Ethnic Groups

for Vaccine Hesitancy

1 location in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06639386·Recruiting

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CBD Delivery with the A-Synaptic GT4 Transdermal Delivery System in with Dravet Syndrome And/or Lennox-Gastaut Syndrome

for Lennox-Gastaut Syndrome (LGS)

1 location in Boston

Sponsor: Alexander Rotenberg

Sex: All·Age: 2 - 55

Code: NCT06738732·Phase 1, Phase 2·Not Yet Recruiting

Nemaline Myopathy Clinical Research Network (NM-CTRN)

for Nemaline Myopathy

5 locations incl. Palo Alto

Sponsor: Stanford University

Sex: All·Age: 0 - 18

Code: NCT06774703·Not Yet Recruiting

A Phase 1 Study of Vaccination With Dendritic Cell (DC)/Multiple Myeloma (MM) Fusions in Combination With Elranatamab in Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

Drug: Elranatamab

2 locations incl. Boston

Sponsor: David Avigan

Sex: All·Age: 18+

Code: NCT06799026·Phase 1·Recruiting

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Study of hALK.CAR T Cells for Patients With Relapsed/Refractory High-risk Neuroblastoma

for Relapsed Neuroblastoma

2 locations incl. Boston

Sponsor: Roberto Chiarle

Sex: All·Age: 12 Months - 29

Code: NCT06803875·Phase 1, Phase 2·Recruiting

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