Paid Clinical Trials in Massachusetts

Massachusetts has 3,584 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 15, 2026.

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3,584 clinical trials

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Myo-inositol During Pregnancy to Prevent Gestational Diabetes

for Pregnancy Related

1 location in Boston

Sponsor: Tufts Medical Center

Sex: Female·Age: 18 - 45

Code: NCT06575868·Recruiting

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A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

for HER2-positive Gastric Cancer

Drug: Rilvegostomig

53 locations incl. Anchorage

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06764875·Phase 3·Recruiting

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Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0

for Acute Kidney Injury

50 locations incl. Birmingham

Sponsor: Indiana University

Sex: All·Age: 0 Minutes - 2 Weeks

Code: NCT06823115·Enrolling By Invitation

Low-Dose Short-Term Ketorolac to Reduce Chronic Opioid Use in Orthopaedic Polytrauma Patients

for Orthopaedic Trauma

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 70

Code: NCT06201676·Phase 4·Recruiting

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Impact of Stimulants and In-Scanner Motion on Attentive Task Performance in ADHD (ADHD_NFB)

for ADHD

1 location in Brookline

Sponsor: Boston Children's Hospital

Sex: All·Age: 12 - 35

Code: NCT06779825·Not Yet Recruiting

Rollover Study for Participants Previously Enrolled in Clinical Trials of Povorcitinib

for Hidradenitis Suppurativa (HS)

Drug: Povorcitinib

108 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT06855498·Phase 3·Recruiting

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Apixaban in Thrombocytopenia

for Deep Vein Thrombosis

1 location in Boston

Sponsor: Rushad Patell

Sex: All·Age: 18+

Code: NCT06886516·EARLY_Phase 1·Recruiting

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Hybrid Closed Loop Effectiveness Trial in Adults With Type 1 Diabetes

for Diabetes Mellitus, Type 1

2 locations incl. Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18 - 75

Code: NCT06236607·Recruiting

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A Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

for Immune Thrombocytopenic Purpura (ITP)

18 locations incl. Los Angeles

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06722235·Phase 3·Recruiting

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Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer

for Gastric Cancer

18 locations incl. New Haven

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06731478·Phase 3·Recruiting

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Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1

for Non-Small Cell Lung Cancer

Drug: Ivonescimab

89 locations incl. Chandler

Sponsor: Summit Therapeutics

Sex: All·Age: 18+

Code: NCT06767514·Phase 3·Recruiting

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A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab Deruxtecan (I-DXd) in Participants With Relapsed/Refractory Extensive-Stage Small Cell Lung Cancer (MK-6070-002)

for Small Cell Lung Cancer

Drug: Gocatamig

9 locations incl. Aurora

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06780137·Phase 1, Phase 2·Recruiting

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Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy

for Prostate Cancer

27 locations incl. Los Angeles

Sponsor: Novartis Pharmaceuticals

Sex: Male·Age: 18 - 100

Code: NCT06780670·Phase 2, Phase 3·Recruiting

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Assessment of a Physio-neuro Platform (SynPhNe) for Home-based Retraining of Hand Function in Stroke Survivors

for Stroke

1 location in Boston

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 21 - 80

Code: NCT02896348·Recruiting

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Study of Patritumab Deruxtecan With Other Anticancer Agents in Participants With HER2 Positive Breast Cancer That Has Spread and Cannot Be Surgically Removed (MK-1022-009)

for Breast Neoplasms

5 locations incl. Aurora

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06686394·Phase 1, Phase 2·Recruiting

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A Phase I Study of SIM0505 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

9 locations incl. Orlando

Sponsor: NextCure, Inc.

Sex: All·Age: 18+

Code: NCT06792552·Phase 1·Recruiting

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A Phase 2 Trial of Ivonescimab for Patients With Advanced, Metastatic Salivary Gland Cancers

for Salivary Gland Cancer

Drug: Ivonescimab

2 locations incl. Boston

Sponsor: Glenn J. Hanna

Sex: All·Age: 18+

Code: NCT06805617·Phase 2·Recruiting

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Effectiveness and Implementation of a Clinician Decision Support System to Prevent Suicidal Behaviors

for Suicide

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05671133·Recruiting

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A Long-term Extension Study of Dazodalibep in Participants With Sjögren's Syndrome (SS)

for Sjögren's Syndrome

Drug: Dazodalibep

31 locations incl. Avondale

Sponsor: Amgen

Sex: All·Age: 18+

Code: NCT06747949·Phase 3·Recruiting

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A Study of HLD-0915 in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)

for Prostate Cancer Metastatic Disease

10 locations incl. Denver

Sponsor: Halda Therapeutics OpCo, Inc.

Sex: Male·Age: 18+

Code: NCT06800313·Phase 1, Phase 2·Recruiting

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A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease

for Huntington Disease

5 locations incl. Boston

Sponsor: Hoffmann-La Roche

Sex: All·Age: 25 - 65

Code: NCT06826612·Phase 1, Phase 2·Recruiting

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SNV4818 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

5 locations incl. Los Angeles

Sponsor: Pikavation Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06736704·Phase 1, Phase 2·Recruiting

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Open-Label Safety Study of Solriamfetol in Subjects With Binge Eating Disorder

for Binge-Eating Disorder

Drug: Solriamfetol

31 locations incl. Encino

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 18 - 56

Code: NCT06878976·Phase 3·Enrolling By Invitation

A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma

for Glioblastoma

3 locations incl. Boston

Sponsor: Ugonma Chukwueke

Sex: All·Age: 18+

Code: NCT06552260·EARLY_Phase 1·Recruiting

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Cannabis, Linked Emotions, and Adolescent Risk Study

for Cannabis Use

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 12 - 18

Code: NCT06576076·Recruiting

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Positive Minds Strong Joints for Knee Osteoarthritis

for Osteoarthritis, Knee

1 location in Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 50+

Code: NCT06493903·Recruiting

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A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

for Sickle Cell Disease

Drug: Etavopivat

50 locations incl. Birmingham

Sponsor: Novo Nordisk A/S

Sex: All·Age: 12+

Code: NCT06612268·Phase 3·Recruiting

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Study of LHP588 in Subjects With P. Gingivalis-Positive Alzheimer's Disease

for Alzheimer Disease

40 locations incl. Phoenix

Sponsor: Lighthouse Pharmaceuticals, Inc.

Sex: All·Age: 55 - 80

Code: NCT06847321·Phase 2·Recruiting

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The Anabolic Effect of Testosterone on Pelvic Floor Muscles

for Stress Urinary Incontinence

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: 60+

Code: NCT06111209·Phase 2·Recruiting

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MB-105 in Patients With CD5 Positive T-cell Lymphoma

for Lymphoma, T-Cell

12 locations incl. San Diego

Sponsor: March Biosciences Inc

Sex: All·Age: 18+

Code: NCT06534060·Phase 2·Recruiting

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A Trial of Hydrus Microstent Versus Goniotomy

for Glaucoma

1 location in Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 40 - 85

Code: NCT06289491·Recruiting

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Post Marketing Observational Study on Safety of BALFAXAR vs. KCENTRA for Reversal of Vitamin K Antagonist Induced Anticoagulation in Adults Undergoing Urgent Surgery or Invasive Procedure

for Vitamin K-Dependent Coagulation Defect

1 location in Boston

Sponsor: Octapharma

Sex: All·Age: 18+

Code: NCT06429787·Recruiting

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Non-healing Venous Leg Ulcers Treated With Standard Care With or Without BR-AC

for Non-infected Venous Leg Ulcer

23 locations incl. Guntersville

Sponsor: BioStem Technologies

Sex: All·Age: 18+

Code: NCT06811909·Recruiting

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Gastrointestinal Dysmotility on Aspiration Risk

for Esophageal Motility Disorders

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 5 - 21

Code: NCT05455359·Phase 4·Recruiting

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A Study of MGC028 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

7 locations incl. San Francisco

Sponsor: MacroGenics

Sex: All·Age: 18+

Code: NCT06723236·Phase 1·Recruiting

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A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

for Advanced Solid Tumors

11 locations incl. Birmingham

Sponsor: Bayer

Sex: All·Age: 18+

Code: NCT06760819·Phase 2·Recruiting

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Evaluation of a Trauma-Informed Partner Violence Intervention Program

for Domestic Violence

2 locations incl. Boston

Sponsor: Boston University

Sex: Male·Age: 18+

Code: NCT06803043·Enrolling By Invitation

IDEAL: Efficacy of Porcine Placental Extracellular Matrix Augmented Plus Standard of Care (SOC) Versus SOC Alone for the Management of Diabetic Foot Ulcers

for Wound Heal

9 locations incl. Los Angeles

Sponsor: ConvaTec Inc.

Sex: All·Age: 18+

Code: NCT06616844·Recruiting

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Efficacy and Safety of GZR18 Every 2 Weeks Versus Tirzepatide and Placebo in Obese or Overweight Participants

for Obesity and Overweight

Drug: Tirzepatide

20 locations incl. Bessemer

Sponsor: Gan and Lee Pharmaceuticals, USA

Sex: All·Age: 18 - 75

Code: NCT06737042·Phase 2·Not Yet Recruiting

Apple Health Study

for Mental Health

2 locations incl. Washington D.C.

Sponsor: Apple Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06958523·Recruiting

Apply to this trial