Paid Clinical Trials in Massachusetts

Massachusetts has 3,587 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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3,587 clinical trials

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Safety and Tolerability Study of ST-503 for Refractory Pain Due to Peripheral Neuropathy (Small Fiber Predominant, SFN)

for Chronic Neuropathic Pain

11 locations incl. Scottsdale

Sponsor: Sangamo Therapeutics

Sex: All·Age: 18+

Code: NCT06980948·Phase 1, Phase 2·Recruiting

Apply to this trial

Measuring Outcomes With Validated Exercise

for Physical Activity

1 location in Boston

Sponsor: Boston University

Sex: All·Age: 18 - 89

Code: NCT07270185·Recruiting

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New Treatment Strategies and Epigenetic Biomarker for Management of Benign Prostatic Hyperplasia

for BPH (Benign Prostatic Hyperplasia)

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: Male·Age: 18+

Code: NCT06944145·Phase 2·Recruiting

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A Study to Evaluate the Efficacy, Safety, and Drug Levels of Deucravacitinib (BMS-986165) in Adolescent Participants With Moderate to Severe Plaque Psoriasis

for Plaque Psoriasis

Drug: Deucravacitinib

42 locations incl. Birmingham

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 12 - 17

Code: NCT06979453·Phase 3·Recruiting

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A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy

for Gastrointestinal Neoplasms

35 locations incl. Phoenix

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT07218926·Phase 3·Recruiting

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A Study of Valemetostat (DS-3201b) in Combination With Darolutamide in Metastatic Castration Resistant Prostate Cancer (mCRPC)

for Metastatic Castration-resistant Prostate Cancer

9 locations incl. La Jolla

Sponsor: Daiichi Sankyo

Sex: Male·Age: 18+

Code: NCT07244341·Phase 1·Recruiting

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A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer

for Squamous Cell Carcinoma of Head and Neck

Drug: Amivantamab

41 locations incl. Chandler

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07276399·Phase 3·Recruiting

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A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)

for Alzheimer Disease

Drug: KarXT

48 locations incl. Chandler

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 55 - 90

Code: NCT06937229·Phase 3·Recruiting

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Enhancing Recovery Capital Amid Opioid Use Disorder Pharmacotherapy: A Pilot Randomized Trial

for Opioid Use Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05245513·Not Yet Recruiting

Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Severe β-Hemoglobinopathies

for Sickle Cell Disease

1 location in Boston

Sponsor: Daniel Bauer

Sex: All·Age: 13 - 40

Code: NCT06647979·Phase 1·Recruiting

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A Phase Ⅰ/Ⅱa Study of SNUG01 in Adult Subjects With ALS

for Amyotrophic Lateral Sclerosis (ALS)

1 location in Boston

Sponsor: SineuGene Therapeutics Co., Ltd.

Sex: All·Age: 18 - 80

Code: NCT07169175·Phase 1, Phase 2·Not Yet Recruiting

A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies

for Advanced Solid Tumors

6 locations incl. Duarte

Sponsor: SEED Therapeutics, Inc.

Sex: All·Age: 16+

Code: NCT07197554·Phase 1·Recruiting

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ARISe at UMass Chan

for Vaccination

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07236034·Recruiting

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First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

for Esophageal Squamous Cell Carcinoma

10 locations incl. Scottsdale

Sponsor: Plexium, Inc.

Sex: All·Age: 18+

Code: NCT07284186·Phase 1·Recruiting

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The Use of High Bile-binding Foods to Reduce Upper Gastrointestinal Bile Acid Concentrations (Aim 1)

for Feeding Difficulties

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 5 - 21

Code: NCT07303738·Phase 4·Recruiting

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Postnatal Exercise to Activate Baby's Brown Fat

for Childhood Obesity Prevention

2 locations incl. Boston

Sponsor: Joslin Diabetes Center

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07467694·Recruiting

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Safety Study of XT-150 in Participants With ALS

for Amyotrophic Lateral Sclerosis (ALS)

4 locations incl. Phoenix

Sponsor: Xalud Therapeutics, Inc.

Sex: All·Age: 18 - 80

Code: NCT06704347·Phase 1·Not Yet Recruiting

Electrostimulation Study for Ocular Graft vs. Host Disease

for Chronic Ocular Graft-versus-host Disease

1 location in Boston

Sponsor: Zhonghui K. Luo, MD, PhD

Sex: All·Age: 18 - 75

Code: NCT07166848·Recruiting

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A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)

for Inflammatory Arthritis

6 locations incl. Phoenix

Sponsor: Smith & Nephew, Inc.

Sex: All·Age: 18 - 80

Code: NCT07199738·Not Yet Recruiting

Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)

for Type 2 Diabetes

52 locations incl. Chandler

Sponsor: Sparrow Pharmaceuticals

Sex: All·Age: 18+

Code: NCT07296484·Phase 2·Recruiting

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Strategic Help With Immunoglobulin to Enhance Protect Against Late Disease (CMV)

for Cytomegalovirus

2 locations incl. Boston

Sponsor: Camille N. Kotton, MD

Sex: All·Age: 18 - 75

Code: NCT06958796·Phase 4·Recruiting

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A Study to Assess the Efficacy and Safety of Debio 4126 in Participants With Acromegaly Previously Treated With Somatostatin Analogs

for Acromegaly

9 locations incl. Los Angeles

Sponsor: Debiopharm International SA

Sex: All·Age: 18+

Code: NCT06930625·Phase 3·Recruiting

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Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial

for Muscle Invasive Bladder Urothelial Carcinoma

143 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07061964·Phase 2·Recruiting

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Infrared Photobiomodulation in Humans With Epilepsy

for Drug Resistant Epilepsy

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT07145489·Recruiting

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A Study to Evaluate the Optimal Dose, Adverse Events and Change in Disease Activity of Intravenous ABBV-706 in Combination With Atezolizumab Versus Standard of Care as First-Line Treatment in Adult Participants With Previously Untreated Extensive Stage Small Cell Lung Cancer

for Small Cell Lung Cancer

Drug: Atezolizumab

9 locations incl. New Haven

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07155174·Phase 2·Recruiting

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SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes

for Type 1 Diabetes

23 locations incl. San Francisco

Sponsor: SAb Biotherapeutics, Inc.

Sex: All·Age: 5 - 40

Code: NCT07187531·Phase 2·Recruiting

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Detrusor Nerve Radiofrequency Ablation for Overactive Bladder in Women

for Overactive Bladder

9 locations incl. Palo Alto

Sponsor: InMode MD Ltd.

Sex: Female·Age: 22 - 80

Code: NCT07209397·Recruiting

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Improving PRO for Patients With Cancer Using ECAs and Data Visualization

for Cancer

1 location in Boston

Sponsor: Tufts Medical Center

Sex: All·Age: 18+

Code: NCT05948618·Enrolling By Invitation

Mirena for the Treatment of Nonatypical Endometrial Hyperplasia for 6 Months

for Endometrial Hyperplasia

69 locations incl. Birmingham

Sponsor: Bayer

Sex: Female·Age: 18+

Code: NCT06904274·Phase 3·Recruiting

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Mosunetuzumab for CLL MRD Clearance

for Leukemia

Drug: Mosunetuzumab

2 locations incl. Boston

Sponsor: Inhye Ahn

Sex: All·Age: 18+

Code: NCT07052695·Phase 1, Phase 2·Recruiting

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ActiveGirls: Physical Activity, Hormone Health, and Diabetes Risk in Early Adolescence

for PCOS (Polycystic Ovary Syndrome)

1 location in Somerville

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 8+

Code: NCT07102797·Recruiting

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A Study of Sasanlimab, Palbociclib and Axitinib in Metastatic Renal Cell Carcinoma

for Metastatic Renal Cell Carcinoma

2 locations incl. Boston

Sponsor: Stephanie Berg

Sex: All·Age: 18+

Code: NCT07123090·Phase 2·Recruiting

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A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease

for Parkinson's Disease

Drug: Prasinezumab

42 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 50 - 85

Code: NCT07174310·Phase 3·Recruiting

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Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment

for Obesity

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 99

Code: NCT07226947·Recruiting

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A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy

for Epileptic Encephalopathy

6 locations incl. Orange

Sponsor: Institut de Recherches Internationales Servier

Sex: All·Age: 2 - 12

Code: NCT07227857·Phase 1, Phase 2·Recruiting

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A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)

for Bipolar Disorder

Drug: Brenipatide

20 locations incl. Orange

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT07286175·Phase 2·Recruiting

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Alzheimer's Registry

for Alzheimer Disease

1 location in Waltham

Sponsor: CorEvitas

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07420075·Enrolling By Invitation

Study of MRM-3379 in Male Participants With Fragile X Syndrome (BLOOM)

for Fragile X Syndrome

15 locations incl. Phoenix

Sponsor: Mirum Pharmaceuticals, Inc.

Sex: Male·Age: 13 - 45

Code: NCT07209462·Phase 2·Recruiting

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Training Inner Speech in Children With Developmental Language Disorder

for Developmental Language Disorder

1 location in Boston

Sponsor: MGH Institute of Health Professions

Sex: All·Age: 8 - 10·Accepts healthy volunteers

Code: NCT06880731·Recruiting

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Phase 4 Study: Long-term Safety and Efficacy of NT-501 in MacTel Type 2, Including Sham Procedure Participants

for Macular Telangiectasia Type 2 (MacTel)

23 locations incl. La Jolla

Sponsor: Neurotech Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06971939·Phase 4·Recruiting

Apply to this trial