Depression Clinical Trials in Lexington, KY

As of June 2026, 1 paid clinical trial is recruiting for Depression in Lexington, Kentucky. Depression studies test rapid-acting antidepressants including ketamine derivatives, psilocybin-assisted therapy, and neuromodulation approaches. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .

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1 clinical trial for Depression

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About research studies in Lexington

Lexington has approximately 508 recruiting research studies across a wide range of therapeutic areas. Kentucky hosts a diverse network of universities, academic medical centers, and community hospitals that run clinical trials across oncology, cardiology, neurology, and many other therapeutic areas.

Top Research Study Locations in Lexington

Researchers run research studies in Lexington, KY at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.

SiteSpecializes inActive trials
University of KentuckyCancer, Heart Failure, Alcohol Use Disorder135
University of Kentucky/Markey Cancer CenterAcute Myeloid Leukemia, Stage IV Lung Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v889
Saint Joseph Hospital EastAnatomic Stage II Breast Cancer AJCC v8, Breast Cancer, Anatomic Stage IV Breast Cancer AJCC v853
Saint Joseph Radiation Oncology Resource CenterBreast Cancer, Prostate Adenocarcinoma, Stage IIIB Lung Cancer AJCC v843
Baptist Health LexingtonBreast Cancer, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v839
Saint Joseph HospitalProstate Adenocarcinoma, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v833
University of Kentucky Medical CenterAdenocarcinoma, Pancreatic Ductal, Advanced Solid Tumor, Cachexia18
Baptist Health HamburgAnatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v811
Kentucky Children's HospitalCancer-related Pain, Cardiac Arrest, Cardiopulmonary Arrest9
University of Kentucky Chandler Medical CenterNeoplasm Metastasis, Carcinoma, Non-Small-Cell Lung, Carcinoma, Transitional Cell9
Markey Cancer CenterBRAF Gene Mutation, Cancer of Lung, Cancer of the Lung7
University of Kentucky Research FoundationAnkylosing Spondylitis, Autoimmune Diseases, Birdshot Chorioretinitis6
Psychopharmacology of Addiction LaboratoryMethamphetamine Use Disorder, Alcohol Use Disorder, Cocaine Use Disorder5
The Research Group of Lexington LLCObesity, Heart Failure, Cardiovascular Disease5
University of Kentucky HospitalTraumatic Brain Injury, Acute Treatment of Migraine, Atrial Fibrillation5
University of Kentucky - Markey Cancer CenterAdvanced Liver Cancers, B-Cell Non-Hodgkins Lymphoma, Breast Cancer4
University of Kentucky Markey Cancer CenterAdvanced Solid Tumor, Bladder Cancer, Breast Cancer4
Bluegrass Epilepsy ResearchFocal Epilepsy3
Bluegrass Epilepsy Research, LLCFocal Epilepsy, Lennox Gastaut Syndrome, Primary Generalized Tonic-Clonic Seizures3
Clinical Trial SiteCerebral Amyloid Angiopathy, Generalized Myasthenia Gravis, High Cardiovascular Risk3
GSK Investigational SiteColonic Neoplasms, Neoplasms, Colon, Neoplasms, Head and Neck3
Research FacilityCarcinoid, Carcinoid Tumor, GEP-NET3
University of Kentucky College of MedicineAcinetobacter Baumannii-calcoaceticus Complex Infection (ABC), Adolescent Congenital Heart Disease, Candidemia3
AMR ClinicalMetabolic Dysfunction-Associated Steatotic Liver Disease, Obesity, Overweight2
AMR LexingtonDiabetic Peripheral Neuropathic Pain, RSV Infection2

Active & Upcoming Studies in Lexington (2026)

Recruiting trials in Lexington grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.

Neurology & pain (36 active studies)

Mental health & behavior (9 active studies)

Eye & vision (4 active studies)

Common conditions studied in Lexington

  • Breast Cancer (11 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
  • Heart Failure (9 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
  • Lung Cancer (8 active studies). Lung cancer research focuses on targeted therapies for specific mutations such as EGFR, ALK, and KRAS, alongside immunotherapy regimens.
  • Stage IV Lung Cancer AJCC v8 (8 active studies). Lung cancer research focuses on targeted therapies for specific mutations such as EGFR, ALK, and KRAS, alongside immunotherapy regimens.
  • Acute Myeloid Leukemia (7 active studies). Leukemia trials evaluate targeted inhibitors, CAR-T cell therapies, and novel combinations for acute and chronic forms of the disease.
  • Malignant Solid Neoplasm (7 active studies). Recruiting Malignant Solid Neoplasm studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.

Leading research sponsors in Lexington

  • National Cancer Institute (NCI)
  • SWOG Cancer Research Network
  • NRG Oncology
  • AstraZeneca
  • Children's Oncology Group

Local regulations and guidelines

Clinical trials in Kentucky are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Kentucky research additionally follows state public health department oversight and any applicable state privacy statutes.

Compensation & what to expect

How payment typically works
Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
Healthy volunteers
Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Lexington. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
What's included beyond payment
Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
Travel and time
Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
Asking about compensation
Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.

How to find a clinical trial in Lexington

Hipa.ai aggregates every recruiting study in Lexington from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.

Frequently asked questions

How many paid clinical trials are currently recruiting in Lexington?

There are approximately 508 recruiting clinical trials in Lexington, Kentucky listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.

Do clinical trials in Lexington pay participants?

Most recruiting trials in Lexington compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.

Who can participate in a clinical trial in Lexington?

Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.

What conditions are most commonly studied in Lexington?

The most common conditions under active study in Lexington include Breast Cancer (11), Heart Failure (9), Lung Cancer (8), Stage IV Lung Cancer AJCC v8 (8), among many others. Browse the list above to explore every recruiting trial.

Are there clinical trials for healthy volunteers in Lexington?

Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Lexington on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.

How do I enroll in a clinical trial in Lexington?

Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.

Where can I take part in paid clinical trials in Lexington?

Recruiting research sites in Lexington include University of Kentucky, University of Kentucky/Markey Cancer Center, Saint Joseph Hospital East, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.

What kinds of studies are recruiting in Lexington right now?

The largest active categories in Lexington are Cancer & tumors (211), Neurology & pain (36), Cardiovascular (30). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.

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Trials by condition in Lexington