Clinical Trials at Mayo Clinic

As of June 2026, 83 paid clinical trials are recruiting at Mayo Clinic, located at Mayo Clinic: Community Health Collaborative, 214 N Hogan St suite 170, Jacksonville, FL 32202, phone (904) 953-1905 in Jacksonville, Florida. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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83 clinical trials at Mayo Clinic

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A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis

for Antineutrophil Cytoplasmic Antibody-associated Vasculitis

60 locations incl. Anchorage

Sponsor: Amgen

Sex: All·Age: 18 - 100

Code: NCT06072482·Phase 4·Recruiting

Apply to this trial

Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)

for Progressive Pulmonary Fibrosis

70 locations incl. Birmingham

Sponsor: United Therapeutics

Sex: All·Age: 18+

Code: NCT05943535·Phase 3·Recruiting

Apply to this trial

A Phase 1 Clinical Study of NXP900 in Subjects With Advanced Cancers

for Advanced Solid Tumor

Drug: NXP900

10 locations incl. Phoenix

Sponsor: Nuvectis Pharma, Inc.

Sex: All·Age: 18+

Code: NCT05873686·Phase 1·Recruiting

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Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients

for Non-Small Cell Lung Cancer

Drug: Ivonescimab

76 locations incl. Phoenix

Sponsor: Summit Therapeutics

Sex: All·Age: 18+

Code: NCT05899608·Phase 3·Recruiting

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Targeted Alpha-Particle Therapy for Advanced Somatostatin Receptor Type 2 (SSTR2) Positive Tumors

for Neuroendocrine Tumors Unresectable

19 locations incl. Jacksonville

Sponsor: Perspective Therapeutics

Sex: All·Age: 18 - 90

Code: NCT05636618·Phase 1, Phase 2·Recruiting

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Safety and Efficacy Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer

for Non-muscle Invasive Bladder Cancer

40 locations incl. Homewood

Sponsor: Protara Therapeutics

Sex: All·Age: 18+

Code: NCT05951179·Phase 2·Recruiting

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Daratumumab for Treatment of Proliferative Glomerulonephritis With Monoclonal Immune Deposits

for Proliferative Glomerulonephritis With Monoclonal IgG Deposits

Drug: Daratumumab

4 locations incl. Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05654506·Phase 2·Recruiting

Apply to this trial

The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

for Atrial Fibrillation

93 locations incl. Phoenix

Sponsor: Johns Hopkins University

Sex: All·Age: 22 - 85

Code: NCT05836987·Phase 3·Recruiting

Apply to this trial

DCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid Tumors

for Advanced or Metastatic Solid Tumors

14 locations incl. Birmingham

Sponsor: DynamiCure Biotechnology

Sex: All·Age: 18+

Code: NCT05785754·Phase 1·Recruiting

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MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma

for Recurrent Melanoma (Skin)

Drug: Nivolumab

13 locations incl. Orange

Sponsor: Perspective Therapeutics

Sex: All·Age: 18 - 90

Code: NCT05655312·Phase 1, Phase 2·Recruiting

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FOG-001 in Locally Advanced or Metastatic Solid Tumors

for Cancer

31 locations incl. Phoenix

Sponsor: Parabilis Medicines, Inc.

Sex: All·Age: 18+

Code: NCT05919264·Phase 1, Phase 2·Recruiting

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Pre-transplant Health Coaching to Improve Patient-Reported Outcomes in Lung Transplant Candidates

for Lung Transplant

3 locations incl. Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05426200·Recruiting

Apply to this trial

Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

for Prostate Cancer

32 locations incl. Birmingham

Sponsor: Janux Therapeutics

Sex: Male·Age: 18 - 100

Code: NCT05519449·Phase 1·Recruiting

Apply to this trial

Highly Selective CDK7 Inhibitor Q901 in Selected Advanced Solid Tumors

for Advanced Cancer

7 locations incl. Phoenix

Sponsor: Qurient Co., Ltd.

Sex: All·Age: 18+

Code: NCT05394103·Phase 1, Phase 2·Recruiting

Apply to this trial

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

for Mesothelioma

25 locations incl. Phoenix

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT05245500·Phase 1·Recruiting

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Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

for Solid Tumors

17 locations incl. Duarte

Sponsor: ORIC Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05315700·Phase 1, Phase 2·Recruiting

Apply to this trial

Proact: A Study of REACT in Subjects With Type 2 Diabetes Mellitus and Chronic Kidney Disease

for Type 2 Diabetes Mellitus

79 locations incl. Huntsville

Sponsor: Prokidney

Sex: All·Age: 30 - 80

Code: NCT05099770·Phase 3·Recruiting

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Study of Pembrolizumab Treatment After CYAD-101 With FOLFOX Preconditioning in Metastatic Colorectal Cancer

for Unresectable Metastatic Colorectal Cancer

2 locations incl. Jacksonville

Sponsor: Celyad Oncology SA

Sex: All·Age: 18+

Code: NCT04991948·Phase 1·Recruiting

Apply to this trial

Leveraging Methylated DNA Markers (MDMs) in the Detection of Endometrial Cancer, Ovarian Cancer, and Cervical Cancer

for Endometrial Cancer

24 locations incl. Phoenix

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT05051722·Recruiting

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A Study of 177Lu-FAP-2286 in Advanced Solid Tumors

for Solid Tumor

20 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT04939610·Phase 1, Phase 2·Recruiting

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Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

for Amyotrophic Lateral Sclerosis

10 locations incl. Phoenix

Sponsor: Target ALS Foundation, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05137665·Recruiting

Apply to this trial

Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

for Ischemic Stroke

31 locations incl. Phoenix

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04916210·Recruiting

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Neurostimulation for Treatment of Chronic Upper Limb Pain After Brachial Plexus Injury

for Brachial Plexus Injury

2 locations incl. Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT04733599·Recruiting

Apply to this trial

Evaluate the Safety and Clinical Activity of HH2853

for FL Lymphoma

4 locations incl. Phoenix

Sponsor: Haihe Biopharma Co., Ltd.

Sex: All·Age: 18+

Code: NCT04390737·Phase 1, Phase 2·Recruiting

Apply to this trial

Optimizing Y90 Therapy for Radiation Lobectomy

for HCC

2 locations incl. Jacksonville

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT04390724·Recruiting

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Sub-Hertz Analysis of Viscoelasticity of Limbs in Patients With Lymphedema

for Lymphedema

2 locations incl. Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT04258319·Enrolling By Invitation

Study of SX-682 Alone and in Combination With Oral or Intravenous Decitabine in Subjects With Myelodysplastic Syndrome

for Myelodysplastic Syndromes

7 locations incl. Jacksonville

Sponsor: Syntrix Biosystems, Inc.

Sex: All·Age: 18+

Code: NCT04245397·Phase 1·Recruiting

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Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body

for Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion

51 locations incl. Mesa

Sponsor: Bayer

Sex: All·Age: All ages

Code: NCT04142437·Recruiting

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Study of APG-2575 as a Single Agent or in Combination With Other Therapeutic Agents for CLL/SLL

for CLL/SLL

7 locations incl. Duarte

Sponsor: Ascentage Pharma Group Inc.

Sex: All·Age: 18 - 85

Code: NCT04215809·Phase 1·Recruiting

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A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-011 in Patients With Advanced Solid Tumor

for Advanced Liver Cancer

6 locations incl. Phoenix

Sponsor: Abbisko Therapeutics Co, Ltd

Sex: All·Age: 18 - 75

Code: NCT04906434·Phase 1·Recruiting

Apply to this trial

Global Utilization And Registry Database for Improved heArt preservatioN

for Heart Diseases

17 locations incl. Stanford

Sponsor: Paragonix Technologies

Sex: All·Age: All ages

Code: NCT04141605·Enrolling By Invitation

Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

187 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting

Apply to this trial

Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration

for Chondrosarcoma

4 locations incl. Jacksonville

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18+

Code: NCT04040205·Phase 2·Recruiting

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Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's Disease

for Alzheimer Disease

2 locations incl. Jacksonville

Sponsor: Mayo Clinic

Sex: Female·Age: 60+·Accepts healthy volunteers

Code: NCT03821857·Phase 4·Recruiting

Apply to this trial

APG-2575 Study of Safety, Tolerability ,PK/PD in Patients With Hematologic Malignancies

for Hematologic Malignancies

3 locations incl. Jacksonville

Sponsor: Ascentage Pharma Group Inc.

Sex: All·Age: 18+

Code: NCT03537482·EARLY_Phase 1·Recruiting

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Longitudinal Imaging Biomarkers of Disease Progression in DLB

for Lewy Body Disease

2 locations incl. Jacksonville

Sponsor: Kejal Kantarci

Sex: All·Age: 18+

Code: NCT03582488·Phase 4·Enrolling By Invitation

CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in Relapsed or Refractory Primary Central Nervous System Lymphoma (R/R PCNSL)

for Relapsed Hematologic Malignancy

Drug: Emavusertib

27 locations incl. Phoenix

Sponsor: Curis, Inc.

Sex: All·Age: 18+

Code: NCT03328078·Phase 1, Phase 2·Recruiting

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Study Evaluating Safety and Efficacy of JCAR017 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)

for Leukemia, Lymphocytic, Chronic, B-Cell

84 locations incl. Birmingham

Sponsor: Juno Therapeutics, a Subsidiary of Celgene

Sex: All·Age: 18+

Code: NCT03331198·Phase 1, Phase 2·Recruiting

Apply to this trial

Exactech Vantage Total Ankle System Post Market Clinical Follow-Up - US Only

for Ankle Rheumatoid Arthritis

2 locations incl. Jacksonville

Sponsor: Exactech

Sex: All·Age: 21+

Code: NCT05619588·Recruiting

Apply to this trial

MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study

for Lumbar Spinal Stenosis

2306 locations incl. Athens

Sponsor: Stryker Instruments

Sex: All·Age: 18+

Code: NCT03072927·Recruiting

Apply to this trial