Paid Clinical Trials in Illinois

Illinois has 2,953 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,953 clinical trials

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Evaluation of the Safety and Efficacy of a Full-Body Electrostimulation Garment for Individuals With Neurological and Neuromuscular Conditions That Cause Spasticity, Hyperreflexia, and Pain

for Multiple Sclerosis

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 75

Code: NCT07132775·Recruiting

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Study of Lenacapavir as a Once-Yearly Injection for HIV Pre-exposure Prophylaxis (PrEP)

for HIV Pre-exposure Prophylaxis

31 locations incl. Birmingham

Sponsor: Gilead Sciences

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT07047716·Phase 3·Recruiting

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EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

for Diabetes Mellitus, Type 2

Drug: Empagliflozin

216 locations incl. Anniston

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07064473·Phase 3·Recruiting

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Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

for Neovascular Age-Related Macular Degeneration (nAMD)

54 locations incl. Scottsdale

Sponsor: 4D Molecular Therapeutics

Sex: All·Age: 50+

Code: NCT07064759·Phase 3·Recruiting

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A Long-Term Follow-Up Observational Study to Evaluate Safety in Subjects Who Have Received a Gene-Modified Regulatory T Cell (Treg) Therapeutic

for Rheumatoid Arthritis (RA)

10 locations incl. San Francisco

Sponsor: Sonoma Biotherapeutics, Inc.

Sex: All·Age: 18 - 71

Code: NCT07123038·Recruiting

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Auricular Acupressure in Prehabilitation

for Frailty

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 50+

Code: NCT06516198·Recruiting

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A Clinical Trial to Evaluate the Safety and Efficacy of COM701 in Relapsed Platinum Sensitive Ovarian Cancer

for Ovarian Cancer

14 locations incl. Augusta

Sponsor: Compugen Ltd

Sex: Female·Age: 18+

Code: NCT06888921·Phase 1, Phase 2·Recruiting

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A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)

for Alzheimer's Disease

Drug: KarXT

30 locations incl. Fullerton

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 60 - 85

Code: NCT06976203·Phase 3·Recruiting

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A Study Investigating the Effectiveness and Safety of Garadacimab for Treating Patients With Hereditary Angioedema (HAE)

for Hereditary Angioedemas

7 locations incl. Phoenix

Sponsor: CSL Behring

Sex: All·Age: 12+

Code: NCT07001280·Recruiting

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Postprandial Response to Fruit Juice

for Blood Glucose

1 location in Addison

Sponsor: Ocean Spray Cranberries, Inc.

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07103083·Recruiting

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Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND)

for Major Depressive Disorder

19 locations incl. Phoenix

Sponsor: Cybin IRL Limited

Sex: All·Age: 18 - 85

Code: NCT06605105·Phase 3·Enrolling By Invitation

A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)

for Bipolar Disorder Type I With Mania

Drug: KarXT

52 locations incl. Glendale

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18 - 65

Code: NCT06929273·Phase 3·Recruiting

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Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis

for Familial Adenomatous Polyposis (FAP)

18 locations incl. Arcadia

Sponsor: Rapamycin Holdings Inc.

Sex: All·Age: 18+

Code: NCT06950385·Phase 3·Recruiting

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Testing the Addition of an Anti-Cancer Drug, Gemcitabine, to Usual Treatment (BCG Alone) in People Whose Non-Muscle Invasive Bladder Cancer (NMIBC) Came Back After Prior BCG Therapy

for Recurrent Non-Muscle Invasive Bladder Carcinoma

56 locations incl. Birmingham

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT07000084·Phase 3·Recruiting

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A Study of CBX-250 in Participants With Relapsed or Refractory Myeloid Leukemias

for High-risk Myelodysplastic Syndrome

11 locations incl. Duarte

Sponsor: Crossbow Therapeutics, Inc.

Sex: All·Age: 12+

Code: NCT06994676·Phase 1·Recruiting

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A Phase 3 Study to Evaluate the Efficacy and Safety of Intravitreal KSI-101 in Participants With Macular Edema Secondary to Inflammation (MESI) - PINNACLE

for Macular Edema Secondary to Inflammation

55 locations incl. Phoenix

Sponsor: Kodiak Sciences Inc

Sex: All·Age: 18+

Code: NCT06996080·Phase 3·Recruiting

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A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)

for Early Alzheimer's Disease

36 locations incl. Irvine

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 50 - 85

Code: NCT07033494·Phase 2·Recruiting

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geniculaR Artery eMBolization for Knee Osteoarthritis (RAMBO) Registry

for Knee Osteoarthristis

1 location in Libertyville

Sponsor: Joint & Vascular Institute

Sex: All·Age: 18+

Code: NCT07380906·Recruiting

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Evaluation of Sensorimotor Ankle Impairments in Chronic Stroke

for Stroke

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06410989·Not Yet Recruiting

Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3

for COPD

18 locations incl. Birmingham

Sponsor: Apreo Health, Inc.

Sex: All·Age: 40 - 84

Code: NCT06891755·Recruiting

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A Study of Mezagitamab in Adults With Kidney Condition Called IgA Nephropathy

for Kidney Disease

40 locations incl. Birmingham

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06963827·Phase 3·Recruiting

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Comparing Single-Session Therapies for Chronic Pain

for Chronic Musculoskeletal Pain

2 locations incl. Chicago

Sponsor: Mark A. Lumley

Sex: All·Age: 18+

Code: NCT07008105·Recruiting

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Reducing Disparities in Knee Arthroscopy for Adolescents

for Knee Injury

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 14 - 18

Code: NCT07580625·Recruiting

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A Pivotal Phase II Clinical Trial of Utidelone Injection Plus Capecitabine in HER2-negative Breast Cancer Patients With Brain Metastases

for HER2-negative Breast Cancer Patients With Brain Metastases

17 locations incl. Duarte

Sponsor: Biostar Pharma, Inc.

Sex: All·Age: 18+

Code: NCT06764940·Phase 2·Recruiting

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Project VIBE: Virtual Intervention for Binge Eating in Adolescents

for Obesity

2 locations incl. Chicago

Sponsor: University of Pittsburgh

Sex: All·Age: 13 - 19

Code: NCT06819813·Recruiting

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Shield Post-Approval Study Protocol

for Colo-rectal Cancer

56 locations incl. Chandler

Sponsor: Guardant Health, Inc.

Sex: All·Age: 45 - 81·Accepts healthy volunteers

Code: NCT06880055·Recruiting

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Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)

for Acute Decompensated Heart Failure

37 locations incl. Irvine

Sponsor: Reprieve Cardiovascular, Inc

Sex: All·Age: 22+

Code: NCT06898515·Phase 3·Recruiting

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A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease

for Alzheimer's Disease

Drug: KarXT

28 locations incl. Long Beach

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 60 - 85

Code: NCT06976216·Phase 3·Recruiting

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Real-world Experience Using Nemolizumab in the Treatment of Moderate-to-Severe Atopic Dermatitis in Adolescents & Adults

for Atopic Dermatitis

Drug: Nemolizumab

59 locations incl. Birmingham

Sponsor: Galderma R&D

Sex: All·Age: 12+

Code: NCT06988605·Recruiting

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A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

for COVID-19 Infection

60 locations incl. Canoga Park

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07013474·Phase 3·Recruiting

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Developing Evidence-Based Cognitive Approaches to Improve Adjustment to Vision Loss

for Depression, Anxiety

1 location in Chicago

Sponsor: The Chicago Lighthouse

Sex: All·Age: 18+

Code: NCT07073521·Recruiting

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Minimal Residual Disease Testing for the Early Detection of Cancer Recurrence in Resectable Stage II-IV Colorectal Cancer Patients

for Resectable Colorectal Carcinoma

13 locations incl. Goodyear

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07125729·Recruiting

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Lenvatinib and Pembrolizumab to Treat Patients With Anal or Rectum Cancer That Has Gotten Worse After Initial Treatment

for Carcinoma, Squamous Cell

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06669572·Phase 2·Recruiting

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A Study to Evaluate Efficacy of Remibrutinib Compared to Dupilumab at Early Timepoints in Adults With Chronic Spontaneous Urticaria Inadequately Controlled by Second Generation H1-antihistamines

for Chronic Spontaneous Urticaria (CSU)

Drug: Remibrutinib

128 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06868212·Phase 3·Recruiting

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Prospective Study to Assess a Diagnostic Aid for Cancer

for Cancer

39 locations incl. Coronado

Sponsor: Harbinger Health

Sex: All·Age: 45+

Code: NCT07046260·Recruiting

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Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)

for Optic Neuritis

31 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07100990·Phase 3·Recruiting

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NBI-1117568-SCZ3032: Long-Term Evaluation of NBI-1117568 in Adults With Schizophrenia

for Schizophrenia

Drug: NBI-1117568

49 locations incl. Bryant

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18 - 65

Code: NCT07114874·Phase 3·Recruiting

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XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)

for Heart Transplant

14 locations incl. La Jolla

Sponsor: XVIVO Perfusion

Sex: All·Age: 18+

Code: NCT06895070·Recruiting

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FITting Non-invasive Tests in Lynch Syndrome Surveillance

for Colorectal Cancer

3 locations incl. Chicago

Sponsor: University of Chicago

Sex: All·Age: 20 - 80

Code: NCT06898996·Recruiting

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ELEVATE-HFpEF Clinical Study

for Heart Failure With Preserved Ejection Fraction (HFpEF)

25 locations incl. Phoenix

Sponsor: Medtronic Cardiac Rhythm and Heart Failure

Sex: All·Age: 40+

Code: NCT06678841·Recruiting

Apply to this trial