Clinical Trials at The University of Texas MD Anderson Cancer Center

As of June 2026, 141 paid clinical trials are recruiting at The University of Texas MD Anderson Cancer Center, located at 1515 HOLCOMBE BLVD UNIT 428, HOUSTON, TX 77030-4028, phone (713) 794-1464 in Houston, Texas. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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141 clinical trials at The University of Texas MD Anderson Cancer Center

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EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active

for Brain Metastases

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06649058·Phase 2·Recruiting

Apply to this trial

Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer

for Extensive-stage Small-cell Lung Cancer

32 locations incl. Tucson

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT06712355·Phase 3·Recruiting

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A Study of the c-Kit Specific Antibody-Drug Conjugate NN3201 for Advanced and/or Metastatic Solid Tumors Known to Express c-Kit

for Gastrointestinal Stromal Tumors

5 locations incl. Ann Arbor

Sponsor: Novelty Nobility, Inc.

Sex: All·Age: 18+

Code: NCT06805825·Phase 1·Recruiting

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A Phase Ib Study of Rezatapopt in Combination With Azacitidine in Patients With TP53Y220C Mutant Myeloid Malignancies (Acute Myeloid Leukemia or Myelodysplastic Syndrome)

for Myelodysplastic Syndrome

Drug: rezatapopt

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06616636·Phase 1·Recruiting

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A Phase I/II Study of IVONESCIMAB in Recurrent Glioblastoma

for Glioblastoma

Drug: Ivonescimab

2 locations incl. Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06672575·Phase 1, Phase 2·Recruiting

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SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma

for Melanoma, Cutaneous Malignant

40 locations incl. Phoenix

Sponsor: Immatics US, Inc.

Sex: All·Age: 18+

Code: NCT06743126·Phase 3·Recruiting

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Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma

for Cutaneous Squamous Cell Carcinoma (CSCC)

Drug: Cemiplimab

45 locations incl. Phoenix

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06585410·Phase 3·Recruiting

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A Study of ADRX-0405 in Subjects With Select Advanced Solid Tumors

for Solid Tumors

8 locations incl. Duarte

Sponsor: Adcentrx Therapeutics

Sex: All·Age: 18+

Code: NCT06710379·Phase 1·Recruiting

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Trial of AMB-05X for Patients With ctDNA(+) Colorectal Cancer After Curative-intent Treatment

for Colorectal Cancer

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06617858·Phase 2·Recruiting

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Feasibility of Accelerated, Personalized rTMS as an Adjuvant for Impulse Control Disorders: a Pilot Study

for Impulse Control Disorder

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 21 - 60

Code: NCT06639594·Phase 1·Recruiting

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The Use of Cytomegalovirus Cell Mediated Immunity to Optimize the Duration of Letermovir Prophylaxis in Hematopoietic Cell Transplant Recipients

for Cytomegalovirus Cell Mediated Immunity

1 location in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06639854·Recruiting

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Anti-GD2 ADC M3554 in Advanced Solid Tumors

for Advanced Solid Tumor

3 locations incl. Boston

Sponsor: EMD Serono Research & Development Institute, Inc.

Sex: All·Age: 18+

Code: NCT06641908·Phase 1·Recruiting

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Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

for Solid Tumor, Adult

19 locations incl. Duarte

Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

Sex: All·Age: 18+

Code: NCT06625775·Phase 1·Recruiting

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Study of NMS-03597812 in Adult Patients With Relapsed/Refractory Acute Myeloid Leukemia

for Relapsed/Refractory Acute Myeloid Leukemia

7 locations incl. Duarte

Sponsor: Nerviano Medical Sciences

Sex: All·Age: 18+

Code: NCT06549790·Phase 1·Recruiting

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Beamion PANTUMOR-1: A Study to Test Whether Zongertinib Helps People With Advanced Cancers With HER2 Alterations

for Solid Tumours

20 locations incl. Anchorage

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06581432·Phase 2·Recruiting

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Phase 1 Study of ACR-2316 in Specific Advanced Solid Tumors

for Specific Advanced Solid Tumors

15 locations incl. Phoenix

Sponsor: Acrivon Therapeutics

Sex: All·Age: 18+

Code: NCT06667141·Phase 1·Recruiting

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A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

for Breast Cancer

165 locations incl. Daphne

Sponsor: Stemline Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06492616·Phase 3·Recruiting

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A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

for Melanoma

104 locations incl. Chandler

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06246916·Phase 3·Recruiting

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A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma

for Multiple Myeloma

50 locations incl. Gilbert

Sponsor: Kite, A Gilead Company

Sex: All·Age: 18+

Code: NCT06413498·Phase 3·Recruiting

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SW-682 in Advanced Solid Tumors

for Advanced Solid Tumor

8 locations incl. Scottsdale

Sponsor: SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany

Sex: All·Age: 18+

Code: NCT06251310·Phase 1·Recruiting

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A Study of NVL-330 in Patients With Advanced or Metastatic HER2-altered NSCLC (HEROEX-1)

for Locally Advanced Solid Tumor

17 locations incl. Irvine

Sponsor: Nuvalent Inc.

Sex: All·Age: 18+

Code: NCT06521554·Phase 1·Recruiting

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VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]

for Advanced Melanoma

Drug: Nivolumab

50 locations incl. Gilbert

Sponsor: Replimune, Inc.

Sex: All·Age: 12+

Code: NCT06264180·Phase 3·Recruiting

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TGRX-678 US Phase I for Subjects with Refractory or Advanced Chronic Myelogenous Leukemia

for Chronic Myelogenous Leukemia

2 locations incl. Houston

Sponsor: Shenzhen TargetRx Co., Ltd.

Sex: All·Age: 18+

Code: NCT06088888·Phase 1·Recruiting

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EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)

for Breast Cancer

53 locations incl. Anchorage

Sponsor: Exact Sciences Corporation

Sex: All·Age: 18+

Code: NCT06401421·Recruiting

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Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

for Metastatic Breast Cancer

29 locations incl. Phoenix

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06324357·Phase 1, Phase 2·Recruiting

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A Study to Customize Ibrutinib Treatment Regimens for Participants With Previously Untreated Chronic Lymphocytic Leukemia

for Leukemia, Lymphocytic, Chronic, B-Cell

Drug: Ibrutinib

32 locations incl. Cerritos

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05963074·Phase 2·Recruiting

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Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

for Colorectal Cancer

32 locations incl. Chandler

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06445062·Phase 1, Phase 2·Recruiting

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Phase 1/2 Study of Intratumoral Injection of STX-001 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab

for Advanced Solid Tumor

6 locations incl. Scottsdale

Sponsor: Strand Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06249048·Phase 1, Phase 2·Recruiting

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Chimeric Antigen Receptor T Cell Redirected to Target CD4 Positive Relapsed Refractory Acute Myeloid Leukemia (AML ) as a Bridge to Allogeneic Stem Cell Transplant

for Acute Myeloid Leukemia

4 locations incl. Miami

Sponsor: Huda Salman

Sex: All·Age: 12+

Code: NCT06197672·Phase 1·Recruiting

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A Study of MGC026 in Participants With Advanced Solid Tumors

for Advanced Solid Tumor

7 locations incl. Los Angeles

Sponsor: MacroGenics

Sex: All·Age: 18+

Code: NCT06242470·Phase 1·Recruiting

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A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

for Advanced Solid Tumor

13 locations incl. Duarte

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06172478·Phase 2·Recruiting

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Chimeric Antigen Receptor T Cell Therapy Redirected to CD4 (CD4CAR)as a Second Line Treatment for Chronic Myelomonocytic Leukemia, CMML.

for Chronic Myelomonocytic Leukemia

4 locations incl. Miami

Sponsor: Huda Salman

Sex: All·Age: 18+

Code: NCT06071624·Phase 1·Recruiting

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A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

for Advanced Solid Tumors With KRAS G12C Mutations

15 locations incl. La Jolla

Sponsor: Frontier Medicines Corporation

Sex: All·Age: 18+

Code: NCT06244771·Phase 1, Phase 2·Recruiting

Apply to this trial

Busulfan Sample Collection Study

for Subjects Treated With Busulfan

2 locations incl. Chicago

Sponsor: Saladax Biomedical, Inc.

Sex: All·Age: All ages

Code: NCT05711732·Recruiting

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Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC

for Non-Small Cell Lung Cancer, NSCLC

26 locations incl. Gilbert

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06162221·Phase 1, Phase 2·Recruiting

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Study of GS-0201 Alone and in Combination in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

4 locations incl. Boston

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT06167317·Phase 1·Recruiting

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FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibodies in Advanced Solid Tumors

for Advanced Solid Tumor

14 locations incl. Gilbert

Sponsor: Fate Therapeutics

Sex: All·Age: 18+

Code: NCT06241456·Phase 1·Recruiting

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Study of Tinengotinib VS. Physician's Choice a Treatment of Subjects With FGFR-altered in Cholangiocarcinoma

for Cholangiocarcinoma

19 locations incl. Santa Monica

Sponsor: TransThera Sciences (Nanjing), Inc.

Sex: All·Age: 18+

Code: NCT05948475·Phase 3·Recruiting

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A Window of Opportunity Trial to Learn if Linvoseltamab is Safe and Well Tolerated, and How Well it Works in Adult Participants With Recently Diagnosed Multiple Myeloma Who Have Not Already Received Treatment

for Multiple Myeloma

Drug: Linvoseltamab

13 locations incl. Los Angeles

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05828511·Phase 1, Phase 2·Recruiting

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Phase 1 Trial of ST-001 nanoFenretinide in Relapsed/Refractory T-cell Non-Hodgkin Lymphoma

for T-cell Lymphoma

10 locations incl. Scottsdale

Sponsor: SciTech Development, Inc.

Sex: All·Age: 18+

Code: NCT04234048·Phase 1·Recruiting

Apply to this trial