A Study of ADRX-0405 in Subjects With Select Advanced Solid Tumors

Part of paid clinical trials in Duarte, California.

Sponsor
Adcentrx Therapeutics
Study ID
NCT06710379
Phase
PHASE1
Status
Recruiting
Apply to this trial

Conditions

  • Solid Tumors

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • ADRX-0405 — DRUG
    Antibody Drug Conjugate targeting STEAP1

Study Details

The primary purpose of this study is to assess the safety, tolerability, and pharmacokinetics, and to identify the optimal dose of ADRX-0405 in patients with select advanced solid tumors.

Key Dates

Start date
Dec 30, 2024
Status verified
Nov 2024
Primary completion
Jul 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
68 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Phase 1a Dose Escalation
    Increasing doses of ADRX-0405 will be administered to identify the maximum tolerated dose (MTD) and the recommended dose to be used in the Phase 1b part.
  • Experimental: Phase 1b Dose Expansion
    ADRX-0405 will be initially administered at the dose recommended from the Phase 1a part in subjects with previously treated mCRPC.

Primary Outcome Measure

Incidence of adverse events [ Time Frame: Until study completion (estimated 2 years) ]

Central Contacts

Locations (8)

FacilityCityStateZIPSite coordinators
City of HopeDuarteCalifornia91010
Erin Morones
[email protected]
626-218-9708
UCLASanta MonicaCalifornia90404
Rosa Vazquez
[email protected]
310-633-8400
START MidwestGrand RapidsMichigan49546
Julie Burns
[email protected]
616-954-5559
University of Minnesota Masonic Cancer CenterMinneapolisMinnesota55455
Patricia Beckman, RN
[email protected]
612-624-2620
NEXT AustinAustinTexas78758
Suhrutha Bushan
[email protected]
(737) 610-5202
The University of Texas MD Anderson Cancer CenterHoustonTexas77030
Jordi Rodon Ahnert, MD, PhD
[email protected]
713-792-5603
START Mountain RegionWest Valley CityUtah84119
Marie Asay
[email protected]
801-907-4770
NEXT VirginiaFairfaxVirginia22031
Blake Patterson
[email protected]
(703) 783-4505

Find similar trials in Duarte, CA

By research site
City of Hope· Duarte, CAUCLA· Santa Monica, CASTART Midwest· Grand Rapids, MIUniversity of Minnesota Masonic Cancer Center· Minneapolis, MNNEXT Austin· Austin, TXThe University of Texas MD Anderson Cancer Center· Houston, TX

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