RecruitingPhase 1Drug trialTGRX-678 US Phase I for Subjects with Refractory or Advanced Chronic Myelogenous LeukemiaThe purpose of this single-arm, open-label, dose escalation + cohort expansion study is to evaluate the safety, tolerability, pharmacokinetic and preliminary efficacy of TGRX-678 in Chronic Myelogenous Leukemia patients who had failure with or are intolerant to TKI treatments.