Clinical Trials at Houston Methodist Hospital

As of June 2026, 146 paid clinical trials are recruiting at Houston Methodist Hospital, located at 6550 FANNIN ST., SM1661, HOUSTON, TX 77030-2717, phone (713) 441-6172 in Houston, Texas. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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146 clinical trials at Houston Methodist Hospital

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Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

1208 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting

Apply to this trial

A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction

for Lung Transplant Rejection

32 locations incl. Birmingham

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT06082037·Phase 3·Recruiting

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To Evaluate Efficacy of Belinostat or Pralatrexate in Combination Against CHOP Alone in PTCL

for Peripheral T Cell Lymphoma

11 locations incl. Clovis

Sponsor: Acrotech Biopharma Inc.

Sex: All·Age: 18+

Code: NCT06072131·Phase 3·Recruiting

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Safety and Efficacy Study of Intravesical Instillation of TARA-002 in Adults With High-grade Non-muscle Invasive Bladder Cancer

for Non-muscle Invasive Bladder Cancer

40 locations incl. Homewood

Sponsor: Protara Therapeutics

Sex: All·Age: 18+

Code: NCT05951179·Phase 2·Recruiting

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Clinical Trial of the Cryosa System for the Treatment of Obstructive Sleep Apnea

for Obstructive Sleep Apnea of Adult

9 locations incl. Aurora

Sponsor: Cryosa, Inc.

Sex: All·Age: 22 - 70

Code: NCT06008626·Recruiting

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Efficacy and Safety of Trimodulin (BT588) in Subjects With Severe Community-acquired Pneumonia (sCAP)

for Community-acquired Pneumonia

19 locations incl. Mobile

Sponsor: Biotest

Sex: All·Age: 18+

Code: NCT05722938·Phase 3·Recruiting

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A Study to Evaluate the Safety and Effect of AVB-101, a Gene Therapy Product, in Subjects With a Genetic Sub-type of Frontotemporal Dementia (FTD-GRN)

for Frontotemporal Dementia

3 locations incl. Columbus

Sponsor: AviadoBio Ltd

Sex: All·Age: 30 - 75

Code: NCT06064890·Phase 1, Phase 2·Recruiting

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Multi-center, Open-label, Single-ascending Dose Study of Safety and Tolerability of TN-201 in Adults With Symptomatic MYBPC3 Mutation-associated HCM

for Hypertrophic Cardiomyopathy

10 locations incl. La Jolla

Sponsor: Tenaya Therapeutics

Sex: All·Age: 18 - 75

Code: NCT05836259·Phase 1, Phase 2·Recruiting

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The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

for Atrial Fibrillation

93 locations incl. Phoenix

Sponsor: Johns Hopkins University

Sex: All·Age: 22 - 85

Code: NCT05836987·Phase 3·Recruiting

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Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

for Anatomic Stage II Breast Cancer AJCC v8

820 locations incl. Birmingham

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05812807·Phase 3·Recruiting

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A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation

for Heart Failure

Drug: Ziltivekimab

184 locations incl. Alexander City

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT05636176·Phase 3·Recruiting

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Venous Ethanol for Ventricular Tachycardia

for Ventricular Tachycardia

1 location in Houston

Sponsor: The Methodist Hospital Research Institute

Sex: All·Age: 18 - 85

Code: NCT05511246·Phase 2·Recruiting

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Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progression in Participants With Bilateral Lung Transplant

for Pre-Bronchiolitis Obliterans Syndrome

20 locations incl. Phoenix

Sponsor: Renovion, Inc.

Sex: All·Age: 18 - 75

Code: NCT05654922·Phase 3·Recruiting

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Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

for Advanced Malignant Solid Neoplasm

475 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: All ages

Code: NCT05564377·Phase 2·Recruiting

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A Study of GEn-1124 in Subjects With Acute Respiratory Distress Syndrome (ARDS)

for Respiratory Distress Syndrome, Acute

11 locations incl. Washington D.C.

Sponsor: GEn1E Lifesciences

Sex: All·Age: 18 - 85

Code: NCT05795465·Phase 2·Recruiting

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Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer

for Stage I Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8

55 locations incl. Washington D.C.

Sponsor: NRG Oncology

Sex: Female·Age: 18+

Code: NCT05646316·Phase 3·Recruiting

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An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

for Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

46 locations incl. Scottsdale

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05667493·Phase 3·Enrolling By Invitation

Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

for Endometrial Carcinoma

403 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT05256225·Phase 3·Recruiting

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EBV Specific T-Lymphocytes for Treatment of EBV-Positive Lymphoma

for EBV-Related Hodgkin Lymphoma

2 locations incl. Houston

Sponsor: Baylor College of Medicine

Sex: All·Age: All ages

Code: NCT04664179·Phase 1·Recruiting

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A Study of Teclistamab in Combination With Daratumumab and Lenalidomide (Tec-DR) and Talquetamab in Combination With Daratumumab and Lenalidomide (Tal-DR) in Participants With Newly Diagnosed Multiple Myeloma

for Multiple Myeloma

Drug: Daratumumab

67 locations incl. Gilbert

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05552222·Phase 3·Recruiting

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Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

for Prostate Cancer

32 locations incl. Birmingham

Sponsor: Janux Therapeutics

Sex: Male·Age: 18 - 100

Code: NCT05519449·Phase 1·Recruiting

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Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation

for Multiple Myeloma

Drug: Teclistamab

42 locations incl. Phoenix

Sponsor: European Myeloma Network B.V.

Sex: All·Age: 18+

Code: NCT05243797·Phase 3·Recruiting

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Neoadjuvant Folfirinox Combined With Pembrolizumab Followed by Surgery for Patients With Resectable Pancreatic Cancer

for Pancreatic Ductal Adenocarcinoma

3 locations incl. Houston

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05132504·Phase 2·Recruiting

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Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials

for Stroke

45 locations incl. Birmingham

Sponsor: University of Cincinnati

Sex: All·Age: 18+

Code: NCT05338697·Recruiting

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The PIVATAL Study -Study of Ventricular Arrhythmia (VTA) Ablation in Left Ventricular Assist Device (LVAD) Patients

for Arrythmia

19 locations incl. Phoenix

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT05034432·Phase 4·Recruiting

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Allogenic Hepatocyte Transplantation Into Periduodenal Lymph Nodes

for End Stage Liver Disease

2 locations incl. Boston

Sponsor: LyGenesis, Inc.

Sex: All·Age: 18 - 70

Code: NCT04496479·Phase 2·Recruiting

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Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs

for Interstitial Lung Disease

14 locations incl. Phoenix

Sponsor: Paragonix Technologies

Sex: All·Age: All ages

Code: NCT04930289·Enrolling By Invitation

IT Matters: The Erectile Restoration Registry

for Erectile Dysfunction

21 locations incl. Los Angeles

Sponsor: Boston Scientific Corporation

Sex: Male·Age: 18+·Accepts healthy volunteers

Code: NCT04200937·Enrolling By Invitation

Cell Therapy for High Risk T-Cell Malignancies Using CD7-Specific CAR Expressed On Autologous T Cells

for T-cell Acute Lymphoblastic Lymphoma

2 locations incl. Houston

Sponsor: Baylor College of Medicine

Sex: All·Age: Up to 75

Code: NCT03690011·Phase 1·Recruiting

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De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

for Stage I Breast Cancer

812 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: All·Age: 50 - 70

Code: NCT04852887·Phase 3·Recruiting

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A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors

for Cervical Cancer

11 locations incl. Clovis

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT04895709·Phase 1, Phase 2·Recruiting

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A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia (cAMeLot-1)

for Acute Leukemia

26 locations incl. Duarte

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 2+

Code: NCT04811560·Phase 1, Phase 2·Recruiting

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A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)

for Pulmonary Arterial Hypertension

27 locations incl. Phoenix

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07218029·Phase 3·Recruiting

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Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM

for Symptomatic Hypertrophic Cardiomyopathy (HCM)

Drug: Aficamten

52 locations incl. Birmingham

Sponsor: Cytokinetics

Sex: All·Age: 18 - 85

Code: NCT04848506·Phase 2, Phase 3·Enrolling By Invitation

TETRAVI Multivirus CTL for Treatment of EBV, CMV, Adenovirus, and BK Infections Post Allogeneic SCT.

for Viral Infection

2 locations incl. Houston

Sponsor: Baylor College of Medicine

Sex: All·Age: All ages

Code: NCT04013802·Phase 1·Recruiting

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Sentinel Node Biopsy in Endometrial Cancer

for Endometrial Cancer Stage I

1 location in Houston

Sponsor: Queensland Centre for Gynaecological Cancer

Sex: Female·Age: 18+

Code: NCT04073706·Phase 3·Recruiting

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Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

for Advanced Lung Non-Squamous Non-Small Cell Carcinoma

Drug: Bevacizumab

604 locations incl. Anchorage

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04181060·Phase 3·Recruiting

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Dynamics of Colonization and Infection by Multidrug-Resistant Pathogens in Immunocompromised and Critically Ill Patients

for Antimicrobial Drug Resistance

2 locations incl. Houston

Sponsor: The Methodist Hospital Research Institute

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06258551·Recruiting

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CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry

for Mitral Regurgitation

9 locations incl. Tucson

Sponsor: Universitätsklinikum Hamburg-Eppendorf

Sex: All·Age: 18+

Code: NCT04688190·Recruiting

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TTVR Early Feasibility Study

for Tricuspid Regurgitation

20 locations incl. Birmingham

Sponsor: Medtronic Cardiovascular

Sex: All·Age: 18+

Code: NCT04433065·Recruiting

Apply to this trial