Dynamics of Colonization and Infection by Multidrug-Resistant Pathogens in Immunocompromised and Critically Ill Patients

Part of paid clinical trials in Houston, Texas.

Sponsor
The Methodist Hospital Research Institute
Study ID
NCT06258551
Status
Recruiting
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Conditions

  • Antibiotic Resistant Infection
  • Antimicrobial Drug Resistance
  • Carbapenem Resistant Bacterial Infection
  • Carbapenem-Resistant Enterobacteriaceae Infection
  • Clostridium Difficile
  • Extended Spectrum Beta-Lactamase Producing Bacteria Infection
  • Vancomycin Resistant Enterococci Infection
  • Vancomycin-Resistant Enterococcal Infection

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

The goal of this observational study is to investigate how bacterial populations from the intestine and mouth of patients change during the hospitalization period and evaluate if some populations of specific bacteria increase or decrease the risk of acquiring an infection or becoming colonized by pathogenic bacteria. Participants will have the following samples collected during enrollment: stool samples (maximum 2x/week), blood draws (1x/week), oral swab (1x/week).

Key Dates

Start date
Dec 8, 2020
Status verified
Feb 2024
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
1,000 participants (estimated)

Arms

  • Arm: Intensive Care Unit
    Patients admitted to an intensive care unit (No interventions administered)
  • Arm: Bone Marrow Transplant Unit
    Patients admitted to a cancer treatment center for allogeneic stem cell transplantation (No interventions administered)

Primary Outcome Measure

Impact of Colonization on Clinical Outcomes Using DOOR Analysis [ Time Frame: 30 days ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Houston Methodist HospitalHoustonTexas77030
Cesar A Arias, MD, PhD, Msc
[email protected]
346-238-4870
Andrea M deTranaltes
[email protected]
713-569-4258
Cesar A Arias, MD, PhD, Msc (PRINCIPAL_INVESTIGATOR)
The University of Texas MD Anderson Cancer CenterHoustonTexas77030
Samuel Shelburne, MD, PhD
[email protected]
713-792-3280

Find similar trials in Houston, TX

By research site
Houston Methodist Hospital· Houston, TXThe University of Texas MD Anderson Cancer Center· Houston, TX

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