Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumabfor Anatomic Stage II Breast Cancer AJCC v8820 locations incl. BirminghamSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT05812807·Phase 3·RecruitingApply to this trial
SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)for Glioma40 locations incl. BirminghamSponsor: Nuvation Bio Inc.Sex: All·Age: 18+Code: NCT05303519·Phase 3·RecruitingApply to this trial
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trialfor Advanced Malignant Solid Neoplasm475 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: All agesCode: NCT05564377·Phase 2·RecruitingApply to this trial
Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trialfor Metastatic Renal Cell Carcinoma313 locations incl. BirminghamSponsor: NRG OncologySex: All·Age: 18+Code: NCT05327686·Phase 2·RecruitingApply to this trial
mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinomafor Advanced Esophageal AdenocarcinomaDrug: Nivolumab785 locations incl. BirminghamSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT05677490·Phase 3·RecruitingApply to this trial
Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Participants With Metastatic Breast Cancerfor Breast Cancer45 locations incl. DothanSponsor: Stemline Therapeutics, Inc.Sex: All·Age: 18+Code: NCT05563220·Phase 1, Phase 2·RecruitingApply to this trial
ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)for H3 K27M67 locations incl. PhoenixSponsor: Jazz PharmaceuticalsSex: All·Age: All agesCode: NCT05580562·Phase 3·RecruitingApply to this trial
BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Studyfor Clinical Stage III Cutaneous Melanoma AJCC v8Drug: Cabozantinib222 locations incl. PhoenixSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT05136196·Phase 2·RecruitingApply to this trial
A Phase 2/3 Study in Adult and Adolescent Participants With SCDfor Sickle Cell Disease24 locations incl. New HavenSponsor: PfizerSex: All·Age: 12+Code: NCT05431088·Phase 2, Phase 3·RecruitingApply to this trial
A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2for Urothelial Carcinoma159 locations incl. GilbertSponsor: Seagen, a wholly owned subsidiary of PfizerSex: All·Age: 18+Code: NCT04879329·Phase 2·RecruitingApply to this trial
Using Aspirin to Improve Immunological Features of Ovarian Tumorsfor Ovarian Cancer4 locations incl. TampaSponsor: H. Lee Moffitt Cancer Center and Research InstituteSex: Female·Age: 18+Code: NCT05080946·EARLY_Phase 1·RecruitingApply to this trial
Ribociclib&Belinostat In Patients w Metastatic Triple Neg Breast Cancer & Recurrent Ovarian Cancer w Response Prediction By Genomicsfor Metastatic Breast CancerDrug: Ribociclib2 locations incl. Salt Lake CitySponsor: University of UtahSex: All·Age: 18+Code: NCT04315233·Phase 1·RecruitingApply to this trial
Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trialfor Plasma Cell Myeloma642 locations incl. AnchorageSponsor: ECOG-ACRIN Cancer Research GroupSex: All·Age: 18+Code: NCT04566328·Phase 3·RecruitingApply to this trial
Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trialfor Extensive Stage Lung Small Cell CarcinomaDrug: Atezolizumab416 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT04402788·Phase 2, Phase 3·RecruitingApply to this trial
Pancreatic Cancer Early Detection Consortiumfor Pancreas Cancer45 locations incl. PhoenixSponsor: Arbor Research Collaborative for HealthSex: All·Age: 18 - 90·Accepts healthy volunteersCode: NCT04970056·RecruitingApply to this trial
A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancerfor Ovarian Carcinoma539 locations incl. BirminghamSponsor: NRG OncologySex: Female·Age: 35 - 50Code: NCT04251052·RecruitingApply to this trial
Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkersfor Pancreatic Neoplasm408 locations incl. BirminghamSponsor: ECOG-ACRIN Cancer Research GroupSex: All·Age: 50 - 75Code: NCT04239573·RecruitingApply to this trial
Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancerfor Clinical Stage I Esophageal Adenocarcinoma AJCC v895 locations incl. PhoenixSponsor: NRG OncologySex: All·Age: 18+Code: NCT03801876·Phase 3·RecruitingApply to this trial
Chemotherapy Before Surgery and Radiation Therapy or Surgery and Radiation Therapy Alone in Treating Patients With Nasal and Paranasal Sinus Cancer That Can Be Removed by Surgeryfor Stage III Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v6 and v7140 locations incl. TucsonSponsor: ECOG-ACRIN Cancer Research GroupSex: All·Age: 18+Code: NCT03493425·Phase 2·RecruitingApply to this trial
Study of NEO-201 in Solid Tumors Expansion Cohortsfor Non Small Cell Lung Cancer2 locations incl. BethesdaSponsor: Precision Biologics, IncSex: All·Age: 18+Code: NCT03476681·Phase 1, Phase 2·RecruitingApply to this trial
Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemiafor B Acute Lymphoblastic Leukemia455 locations incl. BirminghamSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18 - 39Code: NCT03150693·Phase 3·RecruitingApply to this trial
Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgeryfor Head and Neck Squamous Cell Carcinoma676 locations incl. BirminghamSponsor: ECOG-ACRIN Cancer Research GroupSex: All·Age: 18+Code: NCT02734537·Phase 2·RecruitingApply to this trial
Proton Radiation for Unresectable, Borderline Resectable, or Medically Inoperable Carcinoma of the Pancreasfor Pancreatic Cancer4 locations incl. JacksonvilleSponsor: Proton Collaborative GroupSex: All·Age: 18+Code: NCT02598349·Phase 2·RecruitingApply to this trial
TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancerfor Lymphoma, Non-Hodgkin174 locations incl. BirminghamSponsor: American Society of Clinical OncologySex: All·Age: 12+Code: NCT02693535·Phase 2·RecruitingApply to this trial
Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomasfor Intracranial Meningioma780 locations incl. BirminghamSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT02523014·Phase 2·RecruitingApply to this trial
Phase II Protocol of Proton Therapy for Partial Breast Irradiation in Early Stage Breast Cancerfor Breast Cancer9 locations incl. ScottsdaleSponsor: Proton Collaborative GroupSex: Female·Age: 50+Code: NCT01766297·Phase 2·RecruitingApply to this trial
Postoperative or Salvage Radiotherapy (RT) for Node Negative Prostate Cancer Following Radical Prostatectomyfor Prostate Cancer4 locations incl. Little RockSponsor: Proton Collaborative GroupSex: Male·Age: 18+Code: NCT00969111·RecruitingApply to this trial
Registry Study for Radiation Therapy Outcomesfor Neoplasms29 locations incl. ScottsdaleSponsor: Proton Collaborative GroupSex: All·Age: All agesCode: NCT01255748·RecruitingApply to this trial