Clinical Trials at Duke University

As of June 2026, 200 paid clinical trials are recruiting at Duke University, located at 2301 ERWIN ROAD EMERGEENCY MEDICINE RESIDENCY, DURHAM, NC 27710-0001, phone (919) 681-2247 in Durham, North Carolina. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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200 clinical trials at Duke University

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Novel Digital Application for Patients With Acute Leukemia

for Relapsed Adult Acute Myeloid Leukemia

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 120

Code: NCT06472128·Recruiting

Apply to this trial

Imaging Retinal Vasculature in Infant Eyes

for Retinopathy of Prematurity

2 locations incl. Durham

Sponsor: Duke University

Sex: All·Age: Up to 2 Months

Code: NCT05558059·Recruiting

Apply to this trial

REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities

for Coronary Artery Disease

18 locations incl. Glendale

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT06399705·Phase 3·Recruiting

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Cancer and Mild Cognitive Impairment Dyadic Intervention

for Cancer

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 100

Code: NCT05144516·Recruiting

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RIC (Remote Ischemic Conditioning) in Older Individuals

for Old Age

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 65+

Code: NCT06476288·Enrolling By Invitation

REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Women

for Coronary Artery Disease

18 locations incl. Glendale

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT06399692·Phase 3·Recruiting

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Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction

for Heart Failure With Preserved Ejection Fraction

8 locations incl. Naples

Sponsor: Medtronic Cardiac Rhythm and Heart Failure

Sex: All·Age: 18+

Code: NCT05839730·Recruiting

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Safety and Effectiveness of the KOKO Device to Treat Primary Abnormal Postpartum Uterine Bleeding or Hemorrhage

for Postpartum Hemorrhage

19 locations incl. Birmingham

Sponsor: KOKO Medical Inc.

Sex: Female·Age: 18+

Code: NCT06452355·Recruiting

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A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease

for Alzheimer Disease

6 locations incl. Maitland

Sponsor: Eli Lilly and Company

Sex: All·Age: 50 - 85

Code: NCT06297590·Phase 1·Recruiting

Apply to this trial

The APS Phenotyping Study

for ARDS

20 locations incl. Fresno

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT06521502·Recruiting

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ASSESS ALL ALS Study

for Amyotrophic Lateral Sclerosis

31 locations incl. Birmingham

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06578195·Recruiting

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PREVENT ALL ALS Study

for Amyotrophic Lateral Sclerosis

31 locations incl. Birmingham

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06581861·Recruiting

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Prescription of Letrozole for Uterine Myoma

for Leiomyoma, Uterine

5 locations incl. Los Angeles

Sponsor: University of California, San Francisco

Sex: Female·Age: 21 - 53·Accepts healthy volunteers

Code: NCT06143631·Phase 4·Recruiting

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Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen

for Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation, Untreated or Previously Treated With 1 Systemic Treatment Regimen

22 locations incl. Los Angeles

Sponsor: Servier Bio-Innovation LLC

Sex: All·Age: 18+

Code: NCT06127407·Phase 3·Recruiting

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SOC Chemotherapy +/- Tocilizumab for Triple Negative and ER-low Breast Cancers

for Metastatic Breast Cancer

Drug: Tocilizumab

6 locations incl. Atlanta

Sponsor: Kathy Miller

Sex: All·Age: 18+

Code: NCT05846789·Phase 2·Recruiting

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RESET-SSc: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201, a CD19-CAR T Cell Therapy, in Subjects With Systemic Sclerosis

for Systemic Sclerosis

10 locations incl. New Haven

Sponsor: Cabaletta Bio

Sex: All·Age: 18 - 75

Code: NCT06328777·Phase 1, Phase 2·Recruiting

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Functional Incremental Stepping in Place Test (F-IST) Validation

for Intensive Care Medicine

2 locations incl. Boca Raton

Sponsor: Kirby Mayer

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06853236·Recruiting

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Intervention to Improve Communication and Medication Adherence in Lupus

for Systemic Lupus Erythematosus

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 90

Code: NCT06458075·Recruiting

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Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252

for Recurrent High Grade Glioma

2 locations incl. New York

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06126744·Phase 1·Recruiting

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A Study of Tinengotinib (TT-00420) in Combination With Standard Treatments in People With Prostate Cancer

for Prostate Cancer

12 locations incl. New Haven

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: Male·Age: 18+

Code: NCT06457919·Phase 1, Phase 2·Recruiting

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A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia

for Myelofibrosis

Drug: Selinexor

7 locations incl. Duarte

Sponsor: Karyopharm Therapeutics Inc

Sex: All·Age: 18+

Code: NCT05980806·Phase 2·Recruiting

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A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis

for Pulmonary Fibrosis

59 locations incl. Birmingham

Sponsor: Avalyn Pharma Inc.

Sex: All·Age: 18+

Code: NCT06329401·Phase 2·Recruiting

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A Multicenter Trial to Identify Optimal Atezolizumab Biomarkers in the Setting of Recurrent Glioblastoma. The MOAB Trial

for Recurrent Glioblastoma

Drug: Atezolizumab

4 locations incl. San Francisco

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06069726·Phase 2·Recruiting

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Evaluation of SPN-812 (Viloxazine Extended-release Capsule) in Preschool-age Children With ADHD

for Attention-Deficit/Hyperactivity Disorder

47 locations incl. Saraland

Sponsor: Supernus Pharmaceuticals, Inc.

Sex: All·Age: 48 Months - 69 Months

Code: NCT04781140·Phase 4·Recruiting

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Ketones in Heart Failure With Reduced Ejection Fraction

for Heart Failure With Reduced Ejection Fraction

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06195982·Phase 2·Enrolling By Invitation

Project humAn dieTary daTa rEtuRN

for Diet Habit

1 location in Durham

Sponsor: Duke University

Sex: All·Age: Up to 12 Months·Accepts healthy volunteers

Code: NCT06266689·Recruiting

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Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial

for Gram-negative Bacteremia

11 locations incl. San Francisco

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT06080698·Recruiting

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Pulmonary Artery DenerVation Clinical Study Using the Gradient Denervation System in Heart Failure Patients With Pulmonary Hypertension Group 2 (PreVail-PH2 Study)

for Group 2 Pulmonary Hypertension

8 locations incl. Chicago

Sponsor: Gradient Denervation Technologies

Sex: All·Age: 22 - 85

Code: NCT06052072·Enrolling By Invitation

Deep Functional Phenotyping of the ALA Lung Health Cohort

for Lung Diseases

12 locations incl. Birmingham

Sponsor: Johns Hopkins University

Sex: All·Age: 25 - 35·Accepts healthy volunteers

Code: NCT06177717·Recruiting

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QTX3034 in Patients With KRAS G12D Mutation

for Solid Tumors

14 locations incl. Los Angeles

Sponsor: Quanta Therapeutics

Sex: All·Age: 18+

Code: NCT06227377·Phase 1·Recruiting

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A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

9 locations incl. Duarte

Sponsor: Vividion Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06004245·Phase 1·Recruiting

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The ME&MG Digital Solution for Autonomous Assessment of Myasthenia Gravis

for Myasthenia Gravis

11 locations incl. Aurora

Sponsor: Ad scientiam

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05564936·Recruiting

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Androgens and NAFLD Longitudinal Cohort Study

for PCOS

2 locations incl. San Francisco

Sponsor: University of California, San Francisco

Sex: Female·Age: 18 - 42

Code: NCT06124261·Recruiting

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Telephone-based Physical Activity Coaching or Self Monitored Physical Activity to Improve Physical Function in Older Adults Who Are Undergoing Surgery for Lung Cancer and Their Caregivers

for Lung Carcinoma

16 locations incl. Davis

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06196008·Recruiting

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Hyperpolarized 129Xe MRI Lung Health Cohort

for Healthy

6 locations incl. Chicago

Sponsor: University of Kansas Medical Center

Sex: All·Age: 25 - 35

Code: NCT05766384·Recruiting

Apply to this trial

PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

for Heart Failure NYHA Class II

47 locations incl. Phoenix

Sponsor: Endotronix, Inc.

Sex: All·Age: 18+

Code: NCT05934487·Recruiting

Apply to this trial

CTSN Embolic Protection Trial

for Delirium

24 locations incl. North Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 60+

Code: NCT06027788·Recruiting

Apply to this trial

Testing a Device for Automatically TRacking Urine and STool in an Inpatient HCT Setting (Project TRUST)

for Fluid Output

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 80

Code: NCT05520346·Recruiting

Apply to this trial

Intermittent Fasting Using a Fasting-Mimicking Diet to Improve Prostate Cancer Control and Metabolic Outcomes

for Prostate Adenocarcinoma

3 locations incl. Duarte

Sponsor: Stephen Freedland

Sex: Male·Age: All ages

Code: NCT05832086·Phase 2·Recruiting

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Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

for Surgery-Complications

20 locations incl. Little Rock

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT05991453·Recruiting

Apply to this trial