Clinical Trials at Duke University

As of June 2026, 200 paid clinical trials are recruiting at Duke University, located at 2301 ERWIN ROAD EMERGEENCY MEDICINE RESIDENCY, DURHAM, NC 27710-0001, phone (919) 681-2247 in Durham, North Carolina. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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200 clinical trials at Duke University

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Enhancing Resilience Among Patients With Stroke: Implementation of High Intensity Home-based Rehabilitation

for Stroke

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07098286·Enrolling By Invitation

A Phase 2, Open-Label Study of DISC-3405 in Participants With Polycythemia Vera (PV)

for Polycythemia Vera (PV)

15 locations incl. Phoenix

Sponsor: Disc Medicine, Inc

Sex: All·Age: 18+

Code: NCT06985147·Phase 2·Recruiting

Apply to this trial

COMPASS Study for Metastatic Castration-resistant Prostate Cancer

for Prostate Cancer

3 locations incl. San Francisco

Sponsor: Duke University

Sex: Male·Age: 18+

Code: NCT07050433·Recruiting

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Study of EN-374 Gene Therapy in Participants With X-Linked Chronic Granulomatous Disease

for X-Linked Chronic Granulomatous Disease

8 locations incl. Los Angeles

Sponsor: Ensoma

Sex: Male·Age: 3 Months+

Code: NCT06876363·Phase 1, Phase 2·Recruiting

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Detecting Pulmonary Hypertension With the Eko CORE 500 Digital Stethoscope

for Pulmnary Hypertension

2 locations incl. Los Angeles

Sponsor: Eko Devices, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07136623·Recruiting

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Chronic Exogenous Ketosis in HFpEF

for Heart Failure With Preserved Ejection Fraction (HFPEF)

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06937320·Phase 2·Enrolling By Invitation

A Long-Term Follow-Up Observational Study to Evaluate Safety in Subjects Who Have Received a Gene-Modified Regulatory T Cell (Treg) Therapeutic

for Rheumatoid Arthritis (RA)

10 locations incl. San Francisco

Sponsor: Sonoma Biotherapeutics, Inc.

Sex: All·Age: 18 - 71

Code: NCT07123038·Recruiting

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Targeted Remotely-delivered Anti-inflammatory Interventions With Exercise for Rheumatoid Arthritis

for Rheumatoid Arthritis

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06841562·Recruiting

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Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)

for Acute Decompensated Heart Failure

37 locations incl. Irvine

Sponsor: Reprieve Cardiovascular, Inc

Sex: All·Age: 22+

Code: NCT06898515·Phase 3·Recruiting

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Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial

for Preterm Delivery

14 locations incl. Birmingham

Sponsor: The George Washington University Biostatistics Center

Sex: Female·Age: 14+·Accepts healthy volunteers

Code: NCT06980025·Phase 3·Recruiting

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A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

for Heart Failure

29 locations incl. Birmingham

Sponsor: Novo Nordisk A/S

Sex: All·Age: 40 - 84

Code: NCT06979362·Phase 2·Recruiting

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Long-term Characterization of GORE® TAG® Conformable Thoracic Stent Graft With ACTIVE CONTROL System Performance

for Vascular Disease

24 locations incl. Tucson

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06658730·Recruiting

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Neonatal Platelet Transfusion Threshold Trial

for Thrombocytopenia

20 locations incl. Birmingham

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: 1 Hour - 48 Hours·Accepts healthy volunteers

Code: NCT06676904·Recruiting

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Milrinone for Prevention of Post-ligation Cardiac Syndrome Trial

for Post-ligation Cardiac Syndrome

19 locations incl. Birmingham

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: Up to 3 Months

Code: NCT06679855·Phase 3·Recruiting

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A Study to Evaluate Del-brax (Also Referred to as AOC 1020) in Participants With FSHD

for Facioscapulohumeral Muscular Dystrophy

14 locations incl. Orange

Sponsor: Avidity Biosciences, Inc.

Sex: All·Age: 16 - 70

Code: NCT07038200·Phase 3·Recruiting

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DBT-P Treatment Study

for Emotion Dysregulation

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 18 - 45

Code: NCT06963801·Recruiting

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Remotely Monitored, Mobile Health-supported, High Intensity Interval Training Before Hematopoietic Stem Cell Transplant

for Hematopoietic Stem Cell Transplantation

3 locations incl. Kansas City

Sponsor: University of Kansas Medical Center

Sex: All·Age: 18 - 80

Code: NCT06953648·Not Yet Recruiting

Motor Outcomes to Validate Evaluations in Pediatric FSHD (MOVE Peds)

for Muscular Dystrophy, Facioscapulohumeral

6 locations incl. Palo Alto

Sponsor: University of Kansas Medical Center

Sex: All·Age: 5 - 17

Code: NCT06847282·Recruiting

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A Study to Assess the Safety and Effectiveness of the UrOActive® Artificial Urinary sPHincter (AUS)

for Stress Urinary Incontinence (SUI)

13 locations incl. Los Angeles

Sponsor: UroMems SAS

Sex: Male·Age: 22+

Code: NCT06968741·Recruiting

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CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)

for Type 1 Diabetes Mellitus

30 locations incl. Tucson

Sponsor: COUR Pharmaceutical Development Company, Inc.

Sex: All·Age: 12 - 35

Code: NCT06783309·Phase 1, Phase 2·Recruiting

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Urine Methylation Markers in UTUC

for Upper Tract Urothelial Cancer

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06805630·Recruiting

Apply to this trial

Nutrition OUtReach In Systems of Healthcare

for ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION

4 locations incl. Stanford

Sponsor: University of Kansas Medical Center

Sex: All·Age: 8 - 80

Code: NCT06802406·Recruiting

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Impact of Integrated Pet Care on Glycemic Control and Diabetes Responsibility

for Type 1 Diabetes Mellitis

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 10 - 13

Code: NCT06598345·Enrolling By Invitation

A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)

for Mantle Cell Lymphoma

Drug: Sonrotoclax

37 locations incl. Birmingham

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06742996·Phase 3·Recruiting

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Psyllium in Pediatric IBS

for Irritable Bowel Syndrome

1 location in Durham

Sponsor: Dr Bruno Chumpitazi, M.D.

Sex: All·Age: 12 - 17

Code: NCT06639984·Phase 2·Recruiting

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US National TOP Registry

for Lung Transplant

7 locations incl. Phoenix

Sponsor: TransMedics

Sex: All·Age: All ages

Code: NCT06513091·Recruiting

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Genetic and Environmental Risk Factors for Hemorrhagic Stroke

for Stroke

7 locations incl. Chicago

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT00682695·Recruiting

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OUD (Opioid Use Disorder) Target Trial

for Opioid Use Disorder

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06585709·Recruiting

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Rare Glycogen Storage Diseases Natural History Study

for Glycogen Storage Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 0 - 90

Code: NCT06795152·Recruiting

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Dissolved Phase HXe-129 MRI: A Novel Biomarker to Quantify Pulmonary Pathology

for Electronic Cigarette Related Lung Damage

2 locations incl. Durham

Sponsor: Y. Michael Shim, MD

Sex: All·Age: 18 - 35·Accepts healthy volunteers

Code: NCT06856525·Phase 2, Phase 3·Recruiting

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RESTORE: REducing Future fractureS and Improving ouTcOmes of fRagility fracturE

for Osteoporosis

23 locations incl. Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 50+

Code: NCT06455085·Recruiting

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Ivosidenib Plus Durvalumab and Gemcitabine/Cisplatin as First-Line Therapy in Participants With Locally Advanced or Metastatic Cholangiocarcinoma With an IDH1 Mutation

for Locally Advanced, Unresectable or Metastatic Cholangiocarcinoma With an IDH1 Mutation

Drug: Durvalumab

8 locations incl. Los Alamitos

Sponsor: Institut de Recherches Internationales Servier

Sex: All·Age: 18+

Code: NCT06501625·Phase 1, Phase 2·Recruiting

Apply to this trial

Key Longitudinal Associations With Risk and Glioblastoma Outcomes

for Glioblastoma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06625684·Recruiting

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Tipifarnib and Naxitamab for Relapsed/Refractory Neuroblastoma

for Neuroblastoma

12 locations incl. Little Rock

Sponsor: Giselle Sholler

Sex: All·Age: 1 - 21

Code: NCT06540963·Phase 2·Recruiting

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A U.S. Registry of Eosinophilic Esophagitis Pediatric, Adolescent and Adult Patients Treated With DUPIXENT® As Standard of Care

for Eosinophilic Esophagitis (EoE)

54 locations incl. Phoenix

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 1+

Code: NCT06693531·Recruiting

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International CRDS Registry

for Calcium Release Deficiency Syndrome

4 locations incl. San Francisco

Sponsor: Population Health Research Institute

Sex: All·Age: All ages

Code: NCT06508164·Recruiting

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Study of SX-682 Plus Enzalutamide in Men With ARPI-Resistant Metastatic Castration Resistant Prostate Cancer

for Metastatic Castration-resistant Prostate Cancer

6 locations incl. Los Angeles

Sponsor: Syntrix Biosystems, Inc.

Sex: Male·Age: 18+

Code: NCT06228053·Phase 2·Recruiting

Apply to this trial

Azithromycin Prophylaxis for PRElabor CEsarean DElivery Trial

for Obstetrical Complications

14 locations incl. Birmingham

Sponsor: The George Washington University Biostatistics Center

Sex: Female·Age: All ages·Accepts healthy volunteers

Code: NCT06605118·Phase 3·Recruiting

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Lemborexant Treatment of Insomnia Linked to Epilepsy

for Epilepsy

1 location in Durham

Sponsor: University of Manitoba

Sex: All·Age: 18+

Code: NCT06262594·Phase 3·Recruiting

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Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

for Cardiovascular Diseases

37 locations incl. Little Rock

Sponsor: BrioHealth Solutions, Inc.

Sex: All·Age: 18 - 100

Code: NCT06310031·Recruiting

Apply to this trial