Clinical Trials at City of Hope

As of June 2026, 145 paid clinical trials are recruiting at City of Hope, located at 1500 DUARTE RD, DUARTE, CA 91010-3012, phone (626) 256-4673 in Duarte, California. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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145 clinical trials at City of Hope

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A Phase 1 Study of UB-VV111 With and Without Rapamycin in Relapsed/Refractory CD19+ B-cell Malignancies

for Lymphoma, B-Cell

6 locations incl. Duarte

Sponsor: Umoja Biopharma

Sex: All·Age: 18+

Code: NCT06528301·Phase 1·Recruiting

Apply to this trial

A Phase 1 Study of IM-1021 in Participants With Advanced Cancer

for Solid Malignancies

12 locations incl. Duarte

Sponsor: Immunome, Inc.

Sex: All·Age: 18+

Code: NCT06823167·Phase 1·Recruiting

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Phase 1b/2a Randomized Double-blind Study to Investigate Safety Tolerability PK PD Preliminary Efficacy of Oral Administration of SNIPR001 in Patients With Hematologic Malignancy Scheduled for Allogeneic Hematopoietic Stem-Cell Transplant Receiving FQ Prophylaxis & Harboring FQR Ecoli Pre-Transplant

for E Coli Infections

8 locations incl. Duarte

Sponsor: SNIPR Biome Aps.

Sex: All·Age: 18+

Code: NCT06938867·Phase 1, Phase 2·Recruiting

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A Phase 2 Study of WU-CART-007, an Anti-CD7 Allogeneic CAR-T Cell Therapy in T-Cell Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma (T-RRex)

for T-cell Acute Lymphoblastic Leukemia

13 locations incl. Duarte

Sponsor: Wugen, Inc.

Sex: All·Age: 1+

Code: NCT06514794·Phase 2·Recruiting

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A Study of ADRX-0405 in Subjects With Select Advanced Solid Tumors

for Solid Tumors

8 locations incl. Duarte

Sponsor: Adcentrx Therapeutics

Sex: All·Age: 18+

Code: NCT06710379·Phase 1·Recruiting

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A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases

for Recurrent Head and Neck Squamous Cell Carcinoma

8 locations incl. Duarte

Sponsor: Rakuten Medical, Inc.

Sex: All·Age: 18+

Code: NCT06699212·Phase 3·Recruiting

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Evaluate the Safety, Tolerability, Pharmacokinetic Profile, Efficacy of Bl-M11D1

for Relapsed/Refractory Acute Myeloid Leukemia

18 locations incl. Duarte

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT06714591·Phase 1·Recruiting

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A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

for Carcinoma, Non-Small-Cell Lung

Drug: Amivantamab

150 locations incl. Daphne

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06667076·Phase 2·Recruiting

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A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.

for Candidemia

23 locations incl. Birmingham

Sponsor: Basilea Pharmaceutica

Sex: All·Age: 18+

Code: NCT05421858·Phase 3·Recruiting

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A Study of REC-1245 in Participants With Unresectable, Locally Advanced, or Metastatic Cancer

for Unresectable

4 locations incl. Duarte

Sponsor: Recursion Pharmaceuticals Inc.

Sex: All·Age: 12+

Code: NCT06678659·Phase 1, Phase 2·Recruiting

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A First-in-Human Study of MEN2312 in Adults With Advanced Breast Cancer

for Advanced Breast Cancer

35 locations incl. Springdale

Sponsor: Stemline Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06638307·Phase 1·Recruiting

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The Efficacy of PIPAC and Minimally Invasive Radical Resection in High-risk Gastric Cancer Patients.

for Gastric Cancer

1 location in Duarte

Sponsor: Odense University Hospital

Sex: All·Age: 18 - 80

Code: NCT06295094·Phase 2·Not Yet Recruiting

MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

for Pancreatic Ductal Adenocarcinoma

25 locations incl. Duarte

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06586515·Phase 1·Recruiting

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A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies

for Acute Leukemia

9 locations incl. Duarte

Sponsor: Ossium Health, Inc.

Sex: All·Age: 18 - 75

Code: NCT05589896·Phase 1, Phase 2·Recruiting

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A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis)

for Relapsed/Refractory Systemic Light Chain Amyloidosis

Drug: Linvoseltamab

7 locations incl. Duarte

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06292780·Phase 1, Phase 2·Recruiting

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A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

for Head and Neck Squamous Cell Carcinoma

29 locations incl. Duarte

Sponsor: Tempus AI

Sex: All·Age: 18+

Code: NCT06163534·Recruiting

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A Study to Investigate APL-5125 in Adults With Advanced Solid Tumors

for Colorectal Cancer

9 locations incl. Duarte

Sponsor: Apollo Therapeutics Ltd

Sex: All·Age: 18+

Code: NCT06399757·Phase 1, Phase 2·Recruiting

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Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL

for Large B-cell Lymphoma

60 locations incl. Gilbert

Sponsor: Allogene Therapeutics

Sex: All·Age: 18+

Code: NCT06500273·Phase 2·Recruiting

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Study of NXC-201 CAR-T in Patients With Light Chain (AL) Amyloidosis

for Light Chain (AL) Amyloidosis

18 locations incl. Berkeley

Sponsor: Nexcella Inc.

Sex: All·Age: 18 - 120

Code: NCT06097832·Phase 1, Phase 2·Recruiting

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Padeliporfin VTP Treatment for Unresectable Pancreatic Adenocarcinoma

for Locally Advanced Unresectable Pancreatic Adenocarcinoma

2 locations incl. Duarte

Sponsor: Impact Biotech Ltd

Sex: All·Age: 18+

Code: NCT05919238·Phase 1·Recruiting

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Study of REM-422 in Patients With AML or Higher Risk MDS

for Myelodysplastic Syndromes

5 locations incl. Duarte

Sponsor: Remix Therapeutics

Sex: All·Age: 18+

Code: NCT06297941·Phase 1·Recruiting

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Prevention of GvHD in Participants With Hematological Malignancies Undergoing Hematopoietic Stem Cell Transplant (HSCT)

for Hematologic Malignancy

5 locations incl. Duarte

Sponsor: Tr1X, Inc.

Sex: All·Age: 18+

Code: NCT06462365·Phase 1·Recruiting

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Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors

for Ovarian Cancer

17 locations incl. Duarte

Sponsor: Xencor, Inc.

Sex: All·Age: 15+

Code: NCT06276491·Phase 1·Recruiting

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Heated Intraperitoneal Chemotherapy Followed by Niraparib for Ovarian, Primary Peritoneal and Fallopian Tube Cancer

for Stage III Ovarian Cancer

Drug: Niraparib

59 locations incl. Duarte

Sponsor: GOG Foundation

Sex: Female·Age: 18+

Code: NCT05659381·Phase 3·Recruiting

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A Study to Assess Adverse Events, and How Intravenously (IV) Infused ABBV-969 Moves Through the Bodies of Adult Participants With Metastatic Castration-Resistant Prostate Cancer

for Metastatic Castration-Resistant Prostate Cancer

9 locations incl. Duarte

Sponsor: AbbVie

Sex: Male·Age: 18+

Code: NCT06318273·Phase 1·Recruiting

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A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

for Advanced Solid Tumor

13 locations incl. Duarte

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06172478·Phase 2·Recruiting

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Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

for Endometrial Cancer

17 locations incl. Birmingham

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT06293898·Phase 1·Recruiting

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Study of SIRPant-M in Participants With Relapsed or Refractory Non-Hodgkin's Lymphoma

for Refractory Non-Hodgkin Lymphoma

3 locations incl. Duarte

Sponsor: SIRPant Immunotherapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05967416·Phase 1·Recruiting

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A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC)

for Hepatocellular Carcinoma

Drug: Livmoniplimab

13 locations incl. Duarte

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06109272·Phase 2, Phase 3·Recruiting

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A Global Study of the PETAL Consortium

for T-Cell and NK-Cell Neoplasm

10 locations incl. Duarte

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06067347·Recruiting

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Study of Apalutamide With Carotuximab in Metastatic, Castration-Resistant Prostate Cancer

for Castration-resistant Prostate Cancer

Drug: Apalutamide

3 locations incl. Duarte

Sponsor: Edwin Posadas, MD

Sex: Male·Age: 18+

Code: NCT05534646·Phase 2·Recruiting

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A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms

for Neoplasms

11 locations incl. Duarte

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06150157·Phase 1·Recruiting

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Belumosudil for the Pre-emptive Treatment of Patients With Chronic Graft Versus Host Disease

for Chronic Graft Versus Host Disease

5 locations incl. Duarte

Sponsor: Fred Hutchinson Cancer Center

Sex: All·Age: 18+

Code: NCT05996627·Phase 2·Recruiting

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A Long-term Follow-up Study of Subjects Who Received CRISPR CAR T Cellular Therapies

for Hematologic Malignancy

17 locations incl. Duarte

Sponsor: CRISPR Therapeutics AG

Sex: All·Age: 18+

Code: NCT06208878·Enrolling By Invitation

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

for Non-Small Cell Lung Cancer (NSCLC)

Drug: daraxonrasib

21 locations incl. Duarte

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06128551·Phase 1, Phase 2·Recruiting

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A Study of TRK-950 When Used in Combination With Ramucirumab and Paclitaxel in Patients With Gastric Cancer

for Gastric Adenocarcinoma

14 locations incl. Duarte

Sponsor: Toray Industries, Inc

Sex: All·Age: 18+

Code: NCT06038578·Phase 2·Recruiting

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First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations

for Non-Small Cell Lung Cancer

9 locations incl. Duarte

Sponsor: Pierre Fabre Medicament

Sex: All·Age: 18+

Code: NCT06043817·Phase 1, Phase 2·Recruiting

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A Study of Tegavivint (BC2059) in Patients With Advanced Hepatocellular Carcinoma

for Advanced Hepatocellular Carcinoma

7 locations incl. Duarte

Sponsor: Iterion Therapeutics

Sex: All·Age: 18+

Code: NCT05797805·Phase 1, Phase 2·Recruiting

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Treatment Recommendations for Gastrointestinal Cancers Via Large Language Models

for Gastrointestinal Neoplasm Malignant

1 location in Duarte

Sponsor: Chinese Academy of Sciences

Sex: All·Age: 18+

Code: NCT06002425·Recruiting

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Confirmatory Clinical Evaluation of Novilase® Laser Therapy for Focal Destruction of Malignant Breast Tumors

for Malignant Neoplasm of Breast

7 locations incl. Duarte

Sponsor: Novian Health Inc.

Sex: Female·Age: 18+

Code: NCT03463954·Recruiting

Apply to this trial