A Study of REC-1245 in Participants With Unresectable, Locally Advanced, or Metastatic Cancer

Part of paid clinical trials in Duarte, California.

Sponsor
Recursion Pharmaceuticals Inc.
Study ID
NCT06678659
Phase
PHASE1/PHASE2
Status
Recruiting
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Conditions

  • Locally Advanced
  • Metastatic Cancers
  • Relapsed/Refractory Lymphomas
  • Unresectable

Eligibility Criteria

Sex
ALL
Age
12 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • REC-1245 — DRUG
    Oral

Study Details

This is a multi-center, open-label study to investigate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary activity of REC-1245 administered orally on a once daily (QD) schedule in participants with unresectable, locally advanced, or metastatic solid tumors.

Key Dates

Start date
Nov 21, 2024
Status verified
May 2026
Primary completion
Oct 30, 2028
Completion
Oct 30, 2028

Study Design

Enrollment
170 participants (estimated)
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Phase 1a
    Dose Finding
  • Experimental: Phase 1b Cohort A
  • Experimental: Phase 1b Cohort B
  • Experimental: Phase 1b Cohort C
  • Experimental: Phase 1b Cohort D
  • Experimental: Phase 2 Cohort 1 Dose #1
  • Experimental: Phase 2 Cohort 1 Dose #2
  • Experimental: Phase 2 Cohort 2 Dose #1
  • Experimental: Phase 2 Cohort 2 Dose #2

Primary Outcome Measure

Phase 1-Part 1A (Dose Finding)- Number of Participants With Dose Limiting Toxicities (DLTs) [ Time Frame: Initiation of study drug through 4 weeks ]

Locations (4)

FacilityCityStateZIPSite coordinators
City of HopeDuarteCalifornia91010
Mihae Song
[email protected]
877-467-3411
Cleveland ClinicClevelandOhio44195
Jessica Grenbenc
[email protected]
216-444-7923
SCRI Oncology Partners - PPDSNashvilleTennessee37203-
START Mountain RegionWest Valley CityUtah84119
Marie Asay
[email protected]
801-907-4750

Find similar trials in Duarte, CA

By research site
City of Hope· Duarte, CACleveland Clinic· Cleveland, OHSCRI Oncology Partners - PPDS· Nashville, TNSTART Mountain Region· West Valley City, UT

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