Clinical Trials at The Ohio State University

As of June 2026, 154 paid clinical trials are recruiting at The Ohio State University, located at 3600 REED RD UNIT 22, COLUMBUS, OH 43220-4879, phone (614) 293-8000 in Columbus, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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154 clinical trials at The Ohio State University

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A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

for Solid Tumor, Adult

10 locations incl. Gilbert

Sponsor: A2 Biotherapeutics Inc.

Sex: All·Age: 18+

Code: NCT06682793·Phase 1, Phase 2·Recruiting

Apply to this trial

Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia

for Severe Aplastic Anemia

25 locations incl. Birmingham

Sponsor: Medical College of Wisconsin

Sex: All·Age: 3 - 75

Code: NCT06517641·Phase 2·Recruiting

Apply to this trial

Onyx™ Liquid Embolic IDE Clinical Study

for Peripheral Arterial Hemorrhage

18 locations incl. Phoenix

Sponsor: Medtronic Endovascular

Sex: All·Age: 22+

Code: NCT06742801·Recruiting

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A Study of Ranolazine in ALS

for Amyotrophic Lateral Sclerosis

6 locations incl. San Francisco

Sponsor: Swathy Chandrashekhar, MBBS

Sex: All·Age: 18+

Code: NCT06527222·Phase 2·Recruiting

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Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder

for Generalized Anxiety Disorder (GAD)

49 locations incl. Huntsville

Sponsor: AbbVie

Sex: All·Age: 18 - 65

Code: NCT06846320·Phase 2·Recruiting

Apply to this trial

T1D Pregnancy & Me

for Diabetes Mellitus, Type 1

10 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: Female·Age: 18+

Code: NCT06959316·Recruiting

Apply to this trial

Interactive Virtual Occupational Safety Training Designed for Home Healthcare Workers

for Learning

1 location in Columbus

Sponsor: Ohio State University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06974708·Recruiting

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The Foods & Oil to Repair, Correct and Enhance Strength (FORCES) Study

for Sarcopenia

1 location in Columbus

Sponsor: Ohio State University

Sex: All·Age: 65 - 80

Code: NCT06361511·Recruiting

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A Phase 1 Study of ZE50-0134 in Relapsed and Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, and Select Low-grad Lymphomas

for CLL / SLL

4 locations incl. Louisville

Sponsor: Lomond Therapeutics Holdings, Inc.

Sex: All·Age: 18+

Code: NCT06708897·Phase 1·Recruiting

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Vitamin A Supplementation in Allogeneic Stem Cell Transplantation.

for Graft Vs Host Disease

3 locations incl. Tampa

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: All ages

Code: NCT06450925·Phase 2·Recruiting

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Prevention/Reduction of ASRs and PTSD to Sustain Civilian Performance With Sublingual Cyclobenzaprine HCl (TNX-102 SL)

for Acute Stress Reaction

9 locations incl. Birmingham

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 55

Code: NCT06636786·Phase 2·Recruiting

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Trial to Evaluate the Safety & Tolerability of JBZ-001 in Pts With Advanced Solid and Hematological Malignancies

for Solid Tumor

2 locations incl. Columbus

Sponsor: Jabez Bioscience, Inc

Sex: All·Age: 18+

Code: NCT06801002·Phase 1·Recruiting

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DAANCE FOR CHEMOTHERAPY-INDUCED NEUROPATHY

for Cancer of the Breast

2 locations incl. New Haven

Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All·Age: 40+

Code: NCT06749210·Phase 2·Recruiting

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Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma

for AIDS-Related Diffuse Large B-cell Lymphoma

6 locations incl. Duarte

Sponsor: AIDS Malignancy Consortium

Sex: All·Age: 18+

Code: NCT05077527·Phase 1·Recruiting

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Addiction Potential of Very Low Nicotine Filtered Little Cigars

for Smoking (Tobacco) Addiction

1 location in Columbus

Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All·Age: 21 - 75·Accepts healthy volunteers

Code: NCT06630728·Phase 4·Recruiting

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A Phase 1b/2a Study of Pocenbrodib as Monotherapy and in Combination With Darolutamide in Participants With mCRPC

for mCRPC (Metastatic Castration-resistant Prostate Cancer)

18 locations incl. Fountain Valley

Sponsor: Pathos AI, Inc.

Sex: Male·Age: 18+

Code: NCT06785636·Phase 1, Phase 2·Recruiting

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BSB-1001 in Patients Undergoing HLA-Matched Allogenic Hematopoietic Stem Cell Transplant for AML, ALL or MDS

for AML, Adult Recurrent

6 locations incl. Duarte

Sponsor: BlueSphere Bio, Inc

Sex: All·Age: 18 - 70

Code: NCT06704152·Phase 1, Phase 2·Recruiting

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A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy

for Geographic Atrophy

65 locations incl. Phoenix

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: All ages

Code: NCT06779773·Recruiting

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A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease

for Parkinson Disease

45 locations incl. Sun City

Sponsor: Neuron23 Inc.

Sex: All·Age: 40 - 80

Code: NCT06680830·Phase 2·Recruiting

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A Frequency-Modulated Music Intervention to Enhance Cognitive Processing Therapy (CPT) for PTSD

for PTSD - Post Traumatic Stress Disorder

2 locations incl. Columbus

Sponsor: Ohio State University

Sex: All·Age: 18+

Code: NCT06925867·Recruiting

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A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

for Treatment Resistant Depression

34 locations incl. Tucson

Sponsor: atai Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT06524830·Phase 2·Recruiting

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A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma

for Metastatic Uveal Melanoma

Drug: Nivolumab

29 locations incl. Scottsdale

Sponsor: Replimune, Inc.

Sex: All·Age: All ages

Code: NCT06581406·Phase 2, Phase 3·Recruiting

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RESTORE: REducing Future fractureS and Improving ouTcOmes of fRagility fracturE

for Osteoporosis

23 locations incl. Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 50+

Code: NCT06455085·Recruiting

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Evaluation of Neoadjuvant Xaluritamig in Localized Prostate Cancer

for Prostate Cancer

7 locations incl. San Francisco

Sponsor: Amgen

Sex: Male·Age: 18+

Code: NCT06613100·Phase 1·Recruiting

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Retrospective Acute Care Appendectomy Study

for Acute Appendicitis

3 locations incl. Columbus

Sponsor: Intuitive Surgical

Sex: All·Age: 22+

Code: NCT06624215·Recruiting

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A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy

for Age-related Macular Degeneration (AMD)

Drug: Cemdisiran

152 locations incl. Chandler

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 50 - 85

Code: NCT06541704·Phase 3·Recruiting

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Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study)

for Liver Neoplasms

30 locations incl. Fullerton

Sponsor: HistoSonics, Inc.

Sex: All·Age: 22+

Code: NCT06486454·Recruiting

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DCE-MRI Guided Neoadjuvant Chemotherapy for Borderline Resectable Pancreatic Cancer

for Borderline-resectable Pancreatic Cancer

2 locations incl. Indianapolis

Sponsor: Ohio State University

Sex: All·Age: 19+

Code: NCT06173310·Recruiting

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Soquelitinib vs Standard of Care in Participants With Relapsed/Refractory Peripheral T-cell Lymphoma Not Otherwise Specified, Follicular Helper T-cell Lymphomas, or Systemic Anaplastic Large-cell Lymphoma

for Peripheral T-Cell Lymphoma, Not Otherwise Specified

Drug: Soquelitinib

21 locations incl. Duarte

Sponsor: Corvus Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06561048·Phase 3·Recruiting

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Registry for Stage 2 Type 1 Diabetes

for Type 1 Diabetes

37 locations incl. Baltimore

Sponsor: Sanofi

Sex: All·Age: All ages

Code: NCT06481904·Recruiting

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Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

for Treatment Resistant Depression

24 locations incl. Birmingham

Sponsor: Abbott Medical Devices

Sex: All·Age: 22 - 70

Code: NCT06423430·Recruiting

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Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

for Crohn's Disease

64 locations incl. Dothan

Sponsor: AbbVie

Sex: All·Age: 18 - 75

Code: NCT06548542·Phase 2·Recruiting

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Safety and Effectiveness of the KOKO Device to Treat Primary Abnormal Postpartum Uterine Bleeding or Hemorrhage

for Postpartum Hemorrhage

19 locations incl. Birmingham

Sponsor: KOKO Medical Inc.

Sex: Female·Age: 18+

Code: NCT06452355·Recruiting

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Phase 3 Study on the Efficacy and Safety of Human Plasma Derived Antithrombin (Atenativ) in Heparin-Resistant Patients Scheduled to Undergo Cardiac Surgery Necessitating Cardiopulmonary Bypass

for Acquired Antithrombin Deficiency

9 locations incl. Stanford

Sponsor: Octapharma

Sex: All·Age: 18 - 85

Code: NCT06096116·Phase 3·Recruiting

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Melodi Matrix™ in Breast Reconstruction

for Breast Reconstruction

10 locations incl. Palo Alto

Sponsor: Melodi Health, Inc.

Sex: Female·Age: 22+

Code: NCT06027996·Recruiting

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Study of BB-031 in Acute Ischemic Stroke Patients (RAISE)

for Acute Ischemic Stroke

15 locations incl. Scottsdale

Sponsor: Basking Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT06226805·Phase 2·Recruiting

Apply to this trial

Investigations of Reproductive Cancers in Women

for Uterine Cancer

16 locations incl. Birmingham

Sponsor: PinkDx, Inc.

Sex: Female·Age: 45 - 100

Code: NCT06527157·Recruiting

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Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

for Depressive Disorder, Major

Drug: Seltorexant

84 locations incl. Birmingham

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 74

Code: NCT06559306·Phase 3·Recruiting

Apply to this trial

The Mom and Infant Outcomes (MOMI) Study

for Postpartum Depression

1 location in Columbus

Sponsor: Ohio State University

Sex: Female·Age: All ages

Code: NCT06277661·Recruiting

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A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

for Glioblastoma

Drug: Niraparib

32 locations incl. Birmingham

Sponsor: Ivy Brain Tumor Center

Sex: All·Age: 18+

Code: NCT06388733·Phase 3·Recruiting

Apply to this trial