Clinical Trials at Cleveland Clinic

As of June 2026, 375 paid clinical trials are recruiting at Cleveland Clinic, located at Cleveland Clinic Mellen Center, 1950 E 89th St U Bldg, Cleveland, OH 44195, phone (216) 444-8600 in Cleveland, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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375 clinical trials at Cleveland Clinic

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JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS- Cohort B: Paridiprubart

for Acute Respiratory Distress Syndrome (ARDS)

Drug: Cohort B: paridiprubart

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06701669·Phase 2·Recruiting

Apply to this trial

JUST BREATHE, Breathing Life Into Innovative Therapies for ARDS (Master Record)

for Acute Respiratory Distress Syndrome (ARDS)

40 locations incl. Birmingham

Sponsor: PPD Development, LP

Sex: All·Age: 18+

Code: NCT06703073·Phase 2·Recruiting

Apply to this trial

Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986368, for the Treatment of Agitation in Participants With Alzheimer's Disease

for Agitation

53 locations incl. Homewood

Sponsor: Celgene

Sex: All·Age: 55 - 90

Code: NCT06808984·Phase 2·Recruiting

Apply to this trial

A Study to Test Whether BI 1815368 Helps People With an Eye Condition Called Diabetic Macular Edema

for Macular Edema

23 locations incl. Arcadia

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06962839·Phase 2·Recruiting

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A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)

for Leukemia, Myeloid, Acute

Drug: Venetoclax

50 locations incl. Birmingham

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06852222·Phase 3·Recruiting

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A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome

for Dravet Syndrome

Drug: zorevunersen

31 locations incl. Phoenix

Sponsor: Stoke Therapeutics, Inc

Sex: All·Age: 2 - 17

Code: NCT06872125·Phase 3·Recruiting

Apply to this trial

Trial for Reliability of Urodynamics SysTem

for Urologic Diseases

4 locations incl. Murrieta

Sponsor: Bright Uro

Sex: Female·Age: 18+

Code: NCT05694793·Recruiting

Apply to this trial

Surveillance Trial of the Apple Watch in Reliable Burden Assessment in Unseen Recurrence of Surgically Treated AF

for Atrial Fibrillation

2 locations incl. St Louis

Sponsor: The Cleveland Clinic

Sex: All·Age: 22+

Code: NCT07122947·Recruiting

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Evaluation of Cochlear (Promontory) Stimulation During Awake Ear Surgery (TONES Study)

for Hearing Disorder

1 location in Cleveland

Sponsor: Auricle Health Inc.

Sex: All·Age: 18+

Code: NCT07402941·Recruiting

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Topical Ruxolitinib Cream for Refractory Cutaneous Dermatomyositis

for Dermatomyositis

Drug: Ruxolitinib

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 89

Code: NCT06857240·Phase 2·Recruiting

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Assessment of Coronary Microvascular Dysfunction After STEMI Using Continuous Saline Thermodilution

for ST Elevation Myocardial Infarction

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT06795035·Recruiting

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STimulation to Activate RespIration

for ARDS (Moderate or Severe)

5 locations incl. La Jolla

Sponsor: Lungpacer Medical Inc.

Sex: All·Age: 18+

Code: NCT06832306·Recruiting

Apply to this trial

CGM for the Early Detection and Management of Hyperglycemia in Pregnancy

for Gestational Diabetes Mellitus in Pregnancy

8 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06957028·Recruiting

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MagicTouch™Sirolimus-Coated Balloon for Treatment of Coronary Artery Lesions in Small Vessels

for Coronary Artery Disease

24 locations incl. Gilbert

Sponsor: Concept Medical Inc.

Sex: All·Age: 18 - 80

Code: NCT06271590·Recruiting

Apply to this trial

Deep Brain Stimulation of the Deep Cerebellar Nuclei for Refractory Tremor

for Tremor

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 21+

Code: NCT07049003·Phase 1·Recruiting

Apply to this trial

A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo™ Aspiration System (STRIDE II)

for Lower Extremity Acute Limb Ischemia

31 locations incl. Scottsdale

Sponsor: Penumbra Inc.

Sex: All·Age: 18+

Code: NCT06747117·Recruiting

Apply to this trial

PARADIGM - En Bloc Trial With the EndoQuest Endoluminal Surgical (ELS) System

for Colorectal Lesion

6 locations incl. Scottsdale

Sponsor: EndoQuest Robotics, Inc.

Sex: All·Age: 22+

Code: NCT06133387·Recruiting

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Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

for Amyloidosis

Drug: Acoramidis

39 locations incl. La Jolla

Sponsor: Eidos Therapeutics, a BridgeBio company

Sex: All·Age: 18 - 75

Code: NCT06563895·Phase 3·Recruiting

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A Study to Compare TAK-881 and HYQVIA in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

16 locations incl. Scottsdale

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06747351·Phase 3·Recruiting

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Treatment of Moderate to Severe Refractory Crohn's Disease

for Crohns Disease

13 locations incl. Scottsdale

Sponsor: Tr1X, Inc.

Sex: All·Age: 18 - 65

Code: NCT06721962·Phase 1, Phase 2·Recruiting

Apply to this trial

Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.

for Polyp of Colon

2 locations incl. Weston

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT06937671·Recruiting

Apply to this trial

Early Versus Late Adjunctive Vasopressin in Septic Shock

for Sepsis

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT06709573·Phase 4·Recruiting

Apply to this trial

Eganelisib as Monotherapy and in Combination With Cytarabine in Relapsed/Refractory AML

for AML, Adult

11 locations incl. Duarte

Sponsor: Stelexis BioSciences

Sex: All·Age: 18+

Code: NCT06533761·Phase 1·Recruiting

Apply to this trial

Preoperative Fasting vs. Not Fasting in Critically Ill Patients

for Critical Illness

19 locations incl. Palo Alto

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06751043·Recruiting

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A Study to Evaluate the Clinical Outcomes of Efgartigimod PH20 SC in Adults With New-onset Generalized Myasthenia Gravis (gMG)

for New Onset Generalized Myasthenia Gravis (gMG)

Drug: Efgartigimod PH20 SC

18 locations incl. La Jolla

Sponsor: argenx

Sex: All·Age: 18+

Code: NCT06909214·Phase 4·Recruiting

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TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation

for Atrial Fibrillation

Drug: Tirzepatide

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 80

Code: NCT06802081·Phase 2·Recruiting

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CardiolRx in Recurrent Pericarditis (MAVERIC Phase-3)

for Recurrent Pericarditis

21 locations incl. Phoenix

Sponsor: Cardiol Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06708299·Phase 3·Recruiting

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A Study of Tacrolimus/Methotrexate/Ruxolitinib Versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation (BMT CTN 2203)

for Graft-versus-host Disease (GVHD)

Drug: Ruxolitinib

30 locations incl. Palo Alto

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT06615050·Phase 3·Recruiting

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Autologous Bone Marrow Aspirate Treatment for Early-Stage Osteonecrosis

for Osteonecrosis of the Femoral Head

10 locations incl. Los Angeles

Sponsor: Johns Hopkins University

Sex: All·Age: 18 - 90

Code: NCT06123481·Recruiting

Apply to this trial

The Dragon PLC Trial (DRAGON-PLC)

for Primary Liver Cancer

5 locations incl. New Haven

Sponsor: Maastricht University

Sex: All·Age: 18+

Code: NCT06914648·Recruiting

Apply to this trial

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY3537982

85 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06890598·Phase 3·Recruiting

Apply to this trial

CLOSM Trial: Groin Closure Using Layered Option for Suture Material

for Vascular Diseases

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT06990425·Recruiting

Apply to this trial

A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors

for HR+ Breast Cancer

14 locations incl. La Jolla

Sponsor: NiKang Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07029399·Phase 1·Recruiting

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A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

for Relapsed or Refractory Multiple Myeloma (RRMM)

22 locations incl. Birmingham

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06615479·Phase 3·Recruiting

Apply to this trial

Early Assessment and Initiation of GuideLine-Directed Evidence-Based Management-HF

for Heart Failure

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 40+

Code: NCT06849752·Recruiting

Apply to this trial

Alleviant ALLAY-HFrEF Study

for Heart Failure

35 locations incl. Los Angeles

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 18+

Code: NCT06812533·Enrolling By Invitation

The Management of Necrotizing Soft Tissue Infection Wounds With Cytal® Wound Matrix and MicroMatrix®

for Necrotizing Fascitis

1 location in Cleveland

Sponsor: Benjamin T. Miller

Sex: All·Age: 18+

Code: NCT06857708·Recruiting

Apply to this trial

INHANCE Stemless Reverse Shoulder IDE

for Arthroplasty

19 locations incl. Irvine

Sponsor: DePuy Orthopaedics

Sex: All·Age: 22+

Code: NCT06323980·Recruiting

Apply to this trial

Monocytes in Subjects With Type 1 Diabetes and Chronic Kidney Disease

for Chronic Kidney Disease(CKD)

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 65

Code: NCT06694558·Recruiting

Apply to this trial

Impact of Medjool Date Consumption on Labor and Delivery Outcomes

for Spontaneous Labor

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: Female·Age: 18+

Code: NCT07058792·Recruiting

Apply to this trial