Solid tumor Clinical Trials in Chicago, IL
As of June 2026, 72 paid clinical trials are recruiting for Solid tumor in Chicago, Illinois. Recruiting Solid tumor studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Related specialties in Chicago
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72 clinical trials for Solid tumor
·Clear filters·↓ Download CSVA Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
STM-06: POLARIS-POlymetastic Lesion Ablative Radiotherapy With Immunotherapy Study
Web-Based Toolkit to Improve Cancer-Related Emotional Distress and Anxiety in Rural Older Cancer Survivors
Phase 1/2 Study of PYX-201 in Combination With Pembrolizumab in Advanced Solid Tumors
A Study of PHST001 in Advanced Solid Tumors
Safety, Pharmacokinetics, and Efficacy of AI-081, a Bispecific Antibody for PD-1 And VEGF in Advanced Solid Tumors
Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss
Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)
A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer
Study of ISM6331 in Participants With Advanced/Metastatic Malignant Mesothelioma or Other Solid Tumors
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
First-in-human Study of CRB-601-01 to Treat Patients With Advanced Solid Tumor.
Pemetrexed Response in Relation to Tumor Alterations of Gene Status for the Treatment of Patients With Metastatic Urothelial Bladder Cancer and Other Solid Tumors
A Study to Evaluate Safety, Pharmacokinetics, and Activity of GDC-7035 as a Single Agent and in Combination in Patients With Advanced Solid Tumors
A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult Childhood Cancer Survivors, Walking Juntos Study
Comparing Telephone Symptom Monitoring Interventions for Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment
A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body
First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors
SMP-3124LP in Adults With Advanced Solid Tumors
An Extension Study for Patients Previously Enrolled in Studies With Pelabresib
A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours
An Open-label Dose Escalation/Expansion Trial to Evaluate the Safety and Anti-tumor Activity of TEV-56278 Alone or in Combination With Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
Study of SGR-3515 In Participants With Advanced Solid Tumors.
Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)
A Phase 1/2 Study to Investigate CRB-701 in Solid Tumors
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
A Study of Valemetostat Tosylate in Combination With DXd ADCs in Subjects With Solid Tumors
FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibodies in Advanced Solid Tumors
CLN-617 Alone and in Combination With Pembrolizumab in Patients With Advanced Solid Tumors
A Phase 1 Clinical Study of NXP900 in Subjects With Advanced Cancers
Indocyanine Green (ICG) Guided Sentinel Lymph Node Mapping for Pediatric Visceral Solid Tumors
A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors
Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes
Study of MK-0472 in Participants With Advanced/Metastatic Solid Tumors (MK-0472-001)
About research studies in Chicago
Chicago has approximately 2,241 recruiting research studies across a wide range of therapeutic areas. Illinois's research base includes Northwestern Medicine, Rush University Medical Center, University of Chicago Medicine, and Ann & Robert H. Lurie Children's Hospital, covering oncology, cardiology, and pediatric specialties.
Top Research Study Locations in Chicago
Researchers run research studies in Chicago, IL at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Northwestern University | Breast Cancer, Prostate Adenocarcinoma, Stage IV Lung Cancer AJCC v8 | 377 |
| University of Chicago | Heart Failure, Peripheral Artery Disease, Endometrial Cancer | 196 |
| Rush University Medical Center | Angelman Syndrome, Chronic Pain, Atrial Fibrillation | 163 |
| Ann & Robert H. Lurie Children's Hospital of Chicago | High Grade Glioma, Diffuse Intrinsic Pontine Glioma, WHO Grade III Glioma | 122 |
| University of Chicago Medical Center | Breast Cancer, Endometrial Cancer, Kidney Stone | 100 |
| University of Chicago Comprehensive Cancer Center | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome | 97 |
| University of Illinois | Acute Myeloid Leukemia, Breast Cancer, Malignant Solid Neoplasm | 96 |
| Northwestern Memorial Hospital | Heart Failure, Inguinal Hernia Bilateral, Inguinal Hernia Unilateral | 91 |
| University of Illinois at Chicago | Multiple Sclerosis, Carcinoma, Non-Small-Cell Lung, Chronic Stroke | 71 |
| Advocate Illinois Masonic Medical Center | Anatomic Stage II Breast Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Lung Non-Small Cell Carcinoma | 52 |
| The University of Chicago | Head and Neck Cancer, Malnutrition, AML With Gene Mutations | 43 |
| Shirley Ryan AbilityLab | Stroke, Multiple Sclerosis, Spinal Cord Injuries | 39 |
| University of Illinois Chicago | Breast Cancer, Breast Cancer Early Stage Breast Cancer (Stage 1-3), HIV Infections | 35 |
| Lurie Children's Hospital-Chicago | B Acute Lymphoblastic Leukemia, Malignant Solid Neoplasm, Neuroblastoma | 34 |
| Northwestern University Feinberg School of Medicine | Peripheral Artery Disease, Aging, Depression | 32 |
| Rush MD Anderson Cancer Center | Breast Cancer, Stage IV Lung Cancer AJCC v8, Stage IVB Prostate Cancer AJCC v8 | 31 |
| John H Stroger Jr Hospital of Cook County | Malignant Solid Neoplasm, Recurrent Malignant Solid Neoplasm, Anatomic Stage II Breast Cancer AJCC v8 | 30 |
| University of Illinois Cancer Center | Breast Cancer, Gastric Cancer, Cervical Cancer | 27 |
| Northwestern Medicine | Urologic Diseases, AML - Acute Myeloid Leukemia, Amyotrophic Lateral Sclerosis | 23 |
| Rush University | AV Block, Acute Kidney Injury, Adenoma | 23 |
| The University of Chicago Medical Center | Systemic Sclerosis, Acute Myeloid Leukemia, Ovarian Cancer | 23 |
| University of Chicago Medicine Comprehensive Cancer Center | Carcinoma, Squamous Cell, Prostate Cancer, Acute Leukemia | 19 |
| Lurie Children's Hospital | Congenital Heart Disease (CHD), ACL Injury, ACL Tear | 17 |
| University of Chicago Medicine | Advanced Solid Tumor, Lung Cancer, Ulcerative Colitis | 17 |
| Swedish Covenant Hospital | Breast Cancer, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | 15 |
Active & Upcoming Studies in Chicago (2026)
Recruiting trials in Chicago grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (644 active studies)
- BMS-986504 in Combination With Pemetrexed for the Treatment of Metastatic Solid Tumors With MTAP Deletion · Phase 1, Phase 2 · Northwestern University
- Futibatinib With Paclitaxel and Ramucirumab for the Treatment of Locally Advanced or Unresectable Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma · Phase 1 · Northwestern University
Neurology & pain (166 active studies)
- Behavioral Intervention for Lifestyle Physical Activity in Parkinson's Disease · University of Illinois at Chicago
- A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back Pain · Phase 2 · Eli Lilly and Company
Cardiovascular (111 active studies)
- Mobile Health Management of Hypertension · University of Chicago
- PRECISION-CPR: PRecision-Controlled Ventilation in CPR · Rush University Medical Center
Diabetes & metabolic (105 active studies)
- SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease · Phase 2 · Justin Ryder
- Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1) · Phase 3 · Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
Mental health & behavior (80 active studies)
- A Social Network Approach to Improve HIV Prevention and Substance Use Treatment For People Who Use Drugs · NYU Langone Health
- Combining Social Network Strategies and Routine Substance Use Screening · University of California, San Diego
HIV / STI (37 active studies)
- A Social Network Approach to Improve HIV Prevention and Substance Use Treatment For People Who Use Drugs · NYU Langone Health
- A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) During Analytic Treatment Interruption in Participants Living With HIV Who Initiated ART During Acute/Early HIV-1 Infection · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
Pediatric (32 active studies)
- SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease · Phase 2 · Justin Ryder
- A Multicenter Study to Assess the Feasibility of 5-Aminolevulinic Acid (5-ALA) in Pediatric Brain Tumor Patients · Phase 2 · Costas Hadjipanayis
Vaccines (18 active studies)
- Cognitive-Sensorimotor Function in Long-COVID · VA Office of Research and Development
- A Study to Evaluate the Safety and Efficacy of CD388 for Prevention of Influenza · Phase 3 · Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Eye & vision (9 active studies)
- Performance Evaluation of Dream OCT: AP Study · Intalight, Inc
- Phase 4 Study: Long-term Safety and Efficacy of NT-501 in MacTel Type 2, Including Sham Procedure Participants · Phase 4 · Neurotech Pharmaceuticals
Common conditions studied in Chicago
- Breast Cancer (41 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Heart Failure (29 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
- Stroke (28 active studies). Stroke trials test acute reperfusion strategies, neuroprotective agents, and rehabilitation technologies to improve recovery.
- Prostate Cancer (25 active studies). Prostate cancer studies test next-generation hormone therapies, PARP inhibitors, and radioligand treatments for both localized and advanced disease.
- Obesity (24 active studies). Obesity trials evaluate GLP-1 and GIP receptor agonists, novel metabolic drugs, and combined lifestyle interventions for sustainable weight loss.
- Acute Myeloid Leukemia (22 active studies). Leukemia trials evaluate targeted inhibitors, CAR-T cell therapies, and novel combinations for acute and chronic forms of the disease.
Leading research sponsors in Chicago
- Northwestern University
- University of Chicago
- University of Illinois at Chicago
- National Cancer Institute (NCI)
- Rush University Medical Center
Local regulations and guidelines
Clinical trials in Illinois are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Illinois studies must also comply with the Illinois Personal Information Protection Act (PIPA) and Biometric Information Privacy Act (BIPA) where applicable.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Chicago. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Chicago
Hipa.ai aggregates every recruiting study in Chicago from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Chicago?
There are approximately 2,241 recruiting clinical trials in Chicago, Illinois listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Chicago pay participants?
Most recruiting trials in Chicago compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Chicago?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Chicago?
The most common conditions under active study in Chicago include Breast Cancer (41), Heart Failure (29), Stroke (28), Prostate Cancer (25), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Chicago?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Chicago on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Chicago?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Chicago?
Recruiting research sites in Chicago include Northwestern University, University of Chicago, Rush University Medical Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Chicago right now?
The largest active categories in Chicago are Cancer & tumors (644), Neurology & pain (166), Cardiovascular (111). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.