Lung oncology Clinical Trials in Chicago, IL

As of June 2026, 70 paid clinical trials are recruiting for Lung oncology in Chicago, Illinois. Lung oncology trials investigate EGFR, ALK, KRAS, and other driver-mutation targeted therapies alongside immunotherapy combinations for non-small cell, small cell, and mesothelioma studies. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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70 clinical trials for Lung oncology

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A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY3537982

91 locations incl. Huntsville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06119581·Phase 3·Recruiting

Apply to this trial

Stereotactic Body Radiation Therapy Planning With Artificial Intelligence-Directed Dose Recommendation for Treatment of Primary or Metastatic Lung Tumors, RAD-AI Study

for Lung Carcinoma

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT05802186·Recruiting

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A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

for Non-Small Cell Lung Cancer (NSCLC)

Drug: Sotorasib

21 locations incl. Santa Barbara

Sponsor: Amgen

Sex: All·Age: 18 - 100

Code: NCT05920356·Phase 3·Recruiting

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A Phase 1 Clinical Study of NXP900 in Subjects With Advanced Cancers

for Advanced Solid Tumor

Drug: NXP900

10 locations incl. Phoenix

Sponsor: Nuvectis Pharma, Inc.

Sex: All·Age: 18+

Code: NCT05873686·Phase 1·Recruiting

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Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients

for Non-Small Cell Lung Cancer

Drug: Ivonescimab

76 locations incl. Phoenix

Sponsor: Summit Therapeutics

Sex: All·Age: 18+

Code: NCT05899608·Phase 3·Recruiting

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A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal Mesothelioma

for Malignant Peritoneal Mesothelioma

13 locations incl. Chicago

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06057935·Phase 2·Recruiting

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Lung Cancer Screening in High-risk Black Individuals

for Lung Cancer

2 locations incl. Chicago

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50 - 80·Accepts healthy volunteers

Code: NCT05898594·Recruiting

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Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

for Non Small Cell Lung Cancer

24 locations incl. Beverly Hills

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT05983432·Phase 1·Recruiting

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IPH5201 and Durvalumab in Patients With Resectable Non-Small Cell Lung Cancer (MATISSE)

for Non Small Cell Lung Cancer

Drug: Durvalumab

6 locations incl. St. Petersburg

Sponsor: Innate Pharma

Sex: All·Age: 18+

Code: NCT05742607·Phase 2·Recruiting

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Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

for Cervical Cancer

8 locations incl. Chicago

Sponsor: Orano Med Theranostics, SAS

Sex: All·Age: 18+

Code: NCT05283330·Phase 1·Recruiting

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DREAM: Double Lung Transplant REgistry Aimed for Lung-limited Malignancies

for Lung Cancer

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 75

Code: NCT05671887·Recruiting

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Phase 2 Study for the Patient, Who Has Diagnosed With Small Cell Lung Cancer (SCLC) or Non Small Cell Lung Cancer (NSCLC) or Renal Cell Carcinoma (RCC) and Finished the First Line Stand Treatment , Need More Treatment

for Small Cell Lung Cancer

5 locations incl. Birmingham

Sponsor: Advenchen Pharmaceuticals, LLC.

Sex: All·Age: 18+

Code: NCT05363280·Phase 2·Recruiting

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I3LUNG: Integrative Science, Intelligent Data Platform for Individualized LUNG Cancer Care With Immunotherapy

for Non Small Cell Lung Cancer

1 location in Chicago

Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Sex: All·Age: 18+

Code: NCT05537922·Recruiting

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A Study of EP0031 in Patients With Advanced RET-altered Malignancies

for Advanced Solid Tumor

Drug: EP0031

18 locations incl. Los Angeles

Sponsor: Ellipses Pharma

Sex: All·Age: 18+

Code: NCT05443126·Phase 1, Phase 2·Recruiting

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Durvalumab and Ablative Radiation in Small Cell Lung Cancer (DARES)

for Small-cell Lung Cancer

Drug: Durvalumab

2 locations incl. Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT05068232·Phase 2·Recruiting

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Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier

for Pulmonary Nodule, Solitary

22 locations incl. Hartford

Sponsor: Veracyte, Inc.

Sex: All·Age: 29 - 85

Code: NCT06426628·Recruiting

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Testing Tumor Tissue and Blood to Help Select Personalized Treatments for Patients With Suspected Lung Cancers

for NSCLC

21 locations incl. Davis

Sponsor: Lung Cancer Mutation Consortium

Sex: All·Age: All ages

Code: NCT04712877·Recruiting

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Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

for Mesothelioma

25 locations incl. Phoenix

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT05245500·Phase 1·Recruiting

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Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer

for Non-small Cell Lung Cancer

25 locations incl. Little Rock

Sponsor: AstraZeneca

Sex: All·Age: 18 - 95

Code: NCT05061550·Phase 2·Recruiting

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Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors

for Renal Cell Carcinoma (RCC)

46 locations incl. Phoenix

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT05176483·Phase 1·Recruiting

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Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan

for Non-Small Cell Lung Cancer

Drug: Bevacizumab

18 locations incl. Duarte

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT05005403·Phase 1·Recruiting

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A Study of NX-1607 in Adults With Advanced Malignancies

for Ovarian Cancer, Epithelial

10 locations incl. Duarte

Sponsor: Nurix Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05107674·Phase 1·Recruiting

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Prolonged Air Leak (PAL) Autologous Blood Patch Intervention Trial

for Lung Cancer

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT04954625·Enrolling By Invitation

ROSE for Improved Molecular Marker Testing Via EBUS

for Non-small Cell Lung Cancer (NSCLC)

4 locations incl. Chicago

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT04945317·Enrolling By Invitation

Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors

for Solid Tumor, Adult

9 locations incl. San Francisco

Sponsor: Vivace Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT04665206·Phase 1, Phase 2·Recruiting

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Olaparib in Patients With HRD Malignant Mesothelioma

for Mesothelioma

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT04515836·Phase 2·Recruiting

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A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer

38 locations incl. Duarte

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT04302025·Phase 2·Recruiting

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Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

for Lung Non-Small Cell Carcinoma

1150 locations incl. Anchorage

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04267848·Phase 3·Recruiting

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Study of CTDNA Response Adaptive Immuno-Chemotherapy in Lung Cancer

for Lung Cancer

2 locations incl. Chicago

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT04093167·Phase 2, Phase 3·Recruiting

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SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

for Cancer, Metastatic

67 locations incl. Birmingham

Sponsor: Massive Bio, Inc.

Sex: All·Age: All ages

Code: NCT03452774·Recruiting

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Conditions in Lung oncology (Chicago, IL)

Non-small cell lung cancer (NSCLC)· 52 Lung cancer· 17 Mesothelioma· 6 Small cell lung cancer· 4