Behavioral health Clinical Trials in Chicago, IL

As of June 2026, 95 paid clinical trials are recruiting for Behavioral health in Chicago, Illinois. Behavioral health trials span mental-health pharmacotherapy and addiction treatment — testing new agents and therapies for depression, anxiety, opioid use disorder, alcohol use, and tobacco cessation. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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95 clinical trials for Behavioral health

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Developing Evidence-Based Cognitive Approaches to Improve Adjustment to Vision Loss

for Depression, Anxiety

1 location in Chicago

Sponsor: The Chicago Lighthouse

Sex: All·Age: 18+

Code: NCT07073521·Recruiting

Apply to this trial

NBI-1117568-SCZ3032: Long-Term Evaluation of NBI-1117568 in Adults With Schizophrenia

for Schizophrenia

Drug: NBI-1117568

49 locations incl. Bryant

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18 - 65

Code: NCT07114874·Phase 3·Recruiting

Apply to this trial

Test of Target Engagement of Ambiguity Aversion

for Intolerance of Uncertainty

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 25 - 60·Accepts healthy volunteers

Code: NCT06962527·Recruiting

Apply to this trial

Ketamine, SGB and Combination Treatment for TBI-associated Headache or PTSD

for Posttraumatic Headache

3 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06608277·Phase 2·Recruiting

Apply to this trial

E-Mindfulness Approaches for Living After Breast Cancer

for Breast Cancer

332 locations incl. Phoenix

Sponsor: NRG Oncology

Sex: All·Age: 18 - 50

Code: NCT06748222·Phase 3·Recruiting

Apply to this trial

Mood Effects of Serotonin Agonists: Depression

for LSD

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07017478·EARLY_Phase 1·Recruiting

Apply to this trial

Our Voices Matter: Intervention for Depression in Youth

for Depressive Symptoms

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 15 - 20·Accepts healthy volunteers

Code: NCT07216326·Recruiting

Apply to this trial

Randomized Withdrawal Study in Patients With Schizophrenia

for Schizophrenia

22 locations incl. Rogers

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 18 - 65

Code: NCT06961968·Phase 3·Recruiting

Apply to this trial

NBI-1117568-SCZ3029: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia

for Schizophrenia

Drug: NBI-1117568

21 locations incl. Bryant

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18 - 65

Code: NCT06963034·Phase 3·Recruiting

Apply to this trial

Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults

for Electronic Nicotine Delivery Systems

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 26·Accepts healthy volunteers

Code: NCT06395415·Recruiting

Apply to this trial

New Strategies to Enhance Smoking Cessation

for Smoking Cessation

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06751927·Recruiting

Apply to this trial

Fostering Optimal Regulation of Emotion for Prevention of Secondary Trauma (FOREST)

for Burnout

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05942469·Recruiting

Apply to this trial

An Open-Label Study of Azetukalner in Major Depressive Disorder

for Major Depressive Disorder

63 locations incl. Phoenix

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06922110·Phase 3·Enrolling By Invitation

Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

for Major Depressive Disorder (MDD)

21 locations incl. Phoenix

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 18 - 65

Code: NCT06830044·Phase 3·Recruiting

Apply to this trial

A Trial of the Efficacy and Safety of SEP-363856 in Acutely Psychotic Participants With Schizophrenia

for Schizophrenia

35 locations incl. Bentonville

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

Sex: All·Age: 18 - 65

Code: NCT06894212·Phase 3·Recruiting

Apply to this trial

The Trans-Led Care Study

for Substance Abuse

1 location in Chicago

Sponsor: Illinois Institute of Technology

Sex: All·Age: 18+

Code: NCT06880705·Recruiting

Apply to this trial

Digital InteGrated Behavioral TreatmeNt for Comorbid ObesITy and DeprEssion Among Racial and Ethnic Adults Age 50 and Older

for Obesity

2 locations incl. Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 50 - 74

Code: NCT06636058·Recruiting

Apply to this trial

A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

for Treatment Resistant Depression

34 locations incl. Tucson

Sponsor: atai Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT06524830·Phase 2·Recruiting

Apply to this trial

Remotely Observed Methadone Evaluation II

for Opioid Use Disorder

1 location in Chicago

Sponsor: Sonara Health

Sex: All·Age: 18 - 64

Code: NCT06338280·Phase 2·Recruiting

Apply to this trial

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

for Major Depressive Disorder

46 locations incl. Phoenix

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18 - 74

Code: NCT06775379·Phase 3·Recruiting

Apply to this trial

"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"

for Major Depressive Disorder

46 locations incl. Phoenix

Sponsor: Cybin IRL Limited

Sex: All·Age: 18 - 85

Code: NCT06564818·Phase 3·Recruiting

Apply to this trial

Study of ITI-1284 as Monotherapy Treatment in Patients With Generalized Anxiety Disorder

for Generalized Anxiety Disorder

30 locations incl. Birmingham

Sponsor: Intra-Cellular Therapies, Inc.

Sex: All·Age: 18+

Code: NCT06701903·Phase 2·Recruiting

Apply to this trial

Cognitive Training as an Adjunct to Ketamine in Real-world Clinics

for Depression

3 locations incl. Oakland

Sponsor: University of Pittsburgh

Sex: All·Age: 18 - 80

Code: NCT06526078·Enrolling By Invitation

Scalable TELeheaLth Cancer CARe: The STELLAR Program to Treat Cancer Risk Behaviors

for Obesity

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT05687604·Recruiting

Apply to this trial

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

for Treatment Resistant Depression

24 locations incl. Birmingham

Sponsor: Abbott Medical Devices

Sex: All·Age: 22 - 70

Code: NCT06423430·Recruiting

Apply to this trial

Activity and Recreation in Communities for Health

for Depression

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT06093282·Enrolling By Invitation

Massed Prolonged Exposure for PTSD in Substance Use Treatment

for Stress Disorders, Post-Traumatic

4 locations incl. San Diego

Sponsor: Veterans Medical Research Foundation

Sex: All·Age: 18+

Code: NCT06296186·Recruiting

Apply to this trial

J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations

for HIV

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06477588·Recruiting

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Patient Outcome Reporting for Timely Assessments of Life With Post-Traumatic Stress Disorder

for PTSD

2 locations incl. Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06479447·Recruiting

Apply to this trial

Study of ALTO-101 in Patients With Schizophrenia

for Schizophrenia

14 locations incl. Garden Grove

Sponsor: Alto Neuroscience

Sex: All·Age: 21 - 55

Code: NCT06502964·Phase 2·Recruiting

Apply to this trial

Hybrid Type 1 Randomized Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families

for Depression

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 12 - 55

Code: NCT06261463·Recruiting

Apply to this trial

Gut Microbiota-Mediated Inflammatory Interactions Between AUD and HIV Infection

for Alcohol Use Disorder

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 45 - 75·Accepts healthy volunteers

Code: NCT06139224·Recruiting

Apply to this trial

A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

for Major Depressive Disorder

40 locations incl. Bellflower

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT06223880·Phase 4·Recruiting

Apply to this trial

Preventing the Development of Chronic Pain: Treating PTSD at Acute Pain Onset

for PTSD

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18 - 70

Code: NCT05700279·Recruiting

Apply to this trial

StuDy AimED at Increasing AlCohol AbsTinEnce

for Alcohol Use Disorder

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 24·Accepts healthy volunteers

Code: NCT05778734·Recruiting

Apply to this trial

Study of ALTO-300 in MDD

for Major Depressive Disorder

45 locations incl. Phoenix

Sponsor: Alto Neuroscience

Sex: All·Age: 18 - 70

Code: NCT05922878·Phase 2·Recruiting

Apply to this trial

Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis

for Multiple Sclerosis

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 64

Code: NCT05051618·Recruiting

Apply to this trial

Overcoming Nicotine Dependence to Enable Quitting

for Tobacco Use

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT05513872·Phase 1, Phase 2·Recruiting

Apply to this trial

Sensitivity of the NIH Toolbox to Stimulant Treatment in Intellectual Disabilities

for Intellectual Disability

3 locations incl. Sacramento

Sponsor: University of California, Davis

Sex: All·Age: 6 - 24

Code: NCT05301361·Phase 1·Enrolling By Invitation

Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

for Schizophrenia Spectrum and Other Psychotic Disorders

6 locations incl. Hartford

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 40

Code: NCT06740383·Recruiting

Apply to this trial

Conditions in Behavioral health (Chicago, IL)

Depression· 36 Schizophrenia· 21 PTSD (post-traumatic stress disorder)· 9 Anxiety· 8 Opioid use disorder· 7 Substance use disorder· 7 Tobacco / nicotine use· 6 Alcohol use disorder· 5 ADHD· 3 Bipolar disorder· 1 Cannabis use / cannabis use disorder· 1