Cognitive Training as an Adjunct to Ketamine in Real-world Clinics

Part of paid clinical trials in Oakland, California.

Sponsor
University of Pittsburgh
Study ID
NCT06526078
Status
Enrolling By Invitation

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Cognitive Training — BEHAVIORAL
    Sessions of cognitive training exercises (15-20min each) self-administered via a web app
  • Sham Training — BEHAVIORAL
    Sessions of sham training exercises (15-20min each) self-administered via a web app

Study Details

In a sample of patients already receiving ketamine (or esketamine) treatment as part of their clinical care, this project seeks to test whether we can enhance and/or extend (es)ketamine's rapid effects by introducing helpful information delivered by a computer-based cognitive training protocol. This work could ultimately lead to the ability to treat depression more efficiently and with broader dissemination by rapidly priming the brain for helpful forms of learning.

Key Dates

Start date
Nov 12, 2024
Status verified
Apr 2026
Primary completion
May 31, 2029
Completion
May 31, 2029

Study Design

Enrollment
600 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Cognitive Training
    Web-based cognitive training
  • Sham Comparator: Sham Training
    Web-based sham training

Primary Outcome Measure

Montgomery Asberg Depression Rating Scale: During (Es)Ketamine Induction [ Time Frame: Trajectories from baseline through end of 'induction phase' treatments (up to max of 12 weeks) ]

Locations (3)

FacilityCityStateZIPSite coordinators
Kaiser Foundation Research Institute, a division of Kaiser Foundation HospitalsOaklandCalifornia94612-
University of Illinois at ChicagoChicagoIllinois60612-
Baylor College of MedicineHoustonTexas77030-

Find similar trials in Oakland, CA

By condition
Depression
By specialty
PsychiatryMental healthBehavioral health
By research site
Kaiser Foundation Research Institute, a division of Kaiser Foundation Hospitals· Oakland, CAUniversity of Illinois at Chicago· Chicago, ILBaylor College of Medicine· Houston, TX

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