Clinical Trials at Massachusetts General Hospital

As of June 2026, 726 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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726 clinical trials at Massachusetts General Hospital

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Zanubrutinib, Bendamustine, Rituximab Prev. Untreated WM

for Waldenstrom Macroglobulinemia

Drug: Rituximab

5 locations incl. Denver

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06561347·Phase 2·Recruiting

Apply to this trial

GpCRC Pediatric Gastroparesis Registry 2

for Gastroparesis

6 locations incl. Boston

Sponsor: Johns Hopkins Bloomberg School of Public Health

Sex: All·Age: 8 - 25

Code: NCT05981300·Recruiting

Apply to this trial

Family Members At INcreased-risk for Developing Inflammatory Bowel Disease

for Inflammatory Bowel Disease (IBD)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 14+·Accepts healthy volunteers

Code: NCT06655415·Recruiting

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A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma

for Metastatic Uveal Melanoma

Drug: Nivolumab

29 locations incl. Scottsdale

Sponsor: Replimune, Inc.

Sex: All·Age: All ages

Code: NCT06581406·Phase 2, Phase 3·Recruiting

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Physiology of Human Brain Connectivity

for Healthy

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 64·Accepts healthy volunteers

Code: NCT06246942·Recruiting

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Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

for Heart Failure

57 locations incl. Phoenix

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT06526195·Recruiting

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Dose Escalation and Expansion Study of HM16390 Alone or With Pembrolizumab in Advanced or Metastatic Solid Tumors

for Advanced or Metastatic Solid Tumors

2 locations incl. Boston

Sponsor: Hanmi Pharmaceutical Company Limited

Sex: All·Age: 18+

Code: NCT06724016·Phase 1·Recruiting

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Testing the mHealth App Intervention for Nondaily Smokers "SiS4"

for Smoking Cessation

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06678243·Recruiting

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A Decentralized Clinical Trial to Promote Evidence-Based Care for Underserved Patients With Neurofibromatosis 1

for Neurofibromatosis 1

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: All ages

Code: NCT06262113·Recruiting

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Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation

for Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS)

9 locations incl. Denver

Sponsor: Institut de Recherches Internationales Servier

Sex: All·Age: 18+

Code: NCT06465953·Phase 3·Recruiting

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Evaluation of the Safety and Effectiveness of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus

for Normal Pressure Hydrocephalus

28 locations incl. Los Angeles

Sponsor: CereVasc Inc

Sex: All·Age: 60+

Code: NCT06498960·Recruiting

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ADCE-T02, a Tissue Factor Targeted Antibody-Drug Conjugate, in Patients With Selected Advanced Solid Tumours

for Advanced Solid Tumor

5 locations incl. Rogers

Sponsor: Adcendo ApS

Sex: All·Age: 18+

Code: NCT06597721·Phase 1·Recruiting

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A U.S. Registry of Eosinophilic Esophagitis Pediatric, Adolescent and Adult Patients Treated With DUPIXENT® As Standard of Care

for Eosinophilic Esophagitis (EoE)

54 locations incl. Phoenix

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 1+

Code: NCT06693531·Recruiting

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CATALINA-2: A Clinical Study of TORL-1-23 in Platinum-resistant Ovarian Cancer.

for Epithelial Ovarian Cancer

26 locations incl. Phoenix

Sponsor: TORL Biotherapeutics, LLC

Sex: Female·Age: 18+

Code: NCT06690775·Phase 2·Recruiting

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A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer

for Hormone Receptor Positive HER-2 Negative Breast Cancer

35 locations incl. Birmingham

Sponsor: Puma Biotechnology, Inc.

Sex: All·Age: 18+

Code: NCT06369285·Phase 2·Recruiting

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Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML

for Leukemia

53 locations incl. Goodyear

Sponsor: Daiichi Sankyo

Sex: All·Age: 18 - 70

Code: NCT06578247·Phase 3·Recruiting

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REcovery From DEXmedetomidine-induced Unconsciousness

for Anesthesia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06003127·Recruiting

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Acceptability and Safety of MR-C-014 in Persons With Neuromyelitis Optica Spectrum Disorder

for Neuromyelitis Optica Spectrum Disorder

2 locations incl. Atlanta

Sponsor: MedRhythms, Inc.

Sex: All·Age: 18 - 70

Code: NCT06374264·Enrolling By Invitation

Early Internal Fixation Versus NonOperative Care With Early Rehabilitation for LC1 Fragility Fractures of the Pelvis

for Multiple Closed Pelvic Fractures With Disruption of Pelvic Ring

12 locations incl. Phoenix

Sponsor: University of Southern California

Sex: All·Age: 60+

Code: NCT06496867·Recruiting

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Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU

for Consciousness Disorders

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06568536·Recruiting

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Efficacy and Safety of Leadless Pacemakers Versus Left Bundle Area Pacing - A Preliminary Exploration

for Pacemaker Implantation

2 locations incl. Naples

Sponsor: NCH Healthcare System, Inc. dba Naples Comprehensive Health and dba NCH

Sex: All·Age: 18+

Code: NCT06690333·Recruiting

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A Non-interventional, Post-authorisation Safety Study of Patients Treated With Efgartigimod Alfa

for Myasthenia Gravis

17 locations incl. San Francisco

Sponsor: argenx

Sex: All·Age: 18+

Code: NCT06298565·Recruiting

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Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study

for Chronic Subdural Hematoma

31 locations incl. Phoenix

Sponsor: The University of Texas Medical Branch, Galveston

Sex: All·Age: 40 - 90

Code: NCT06347796·Recruiting

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Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

for Solid Tumor, Adult

19 locations incl. Duarte

Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

Sex: All·Age: 18+

Code: NCT06625775·Phase 1·Recruiting

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Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

for Cardiovascular Diseases

37 locations incl. Little Rock

Sponsor: BrioHealth Solutions, Inc.

Sex: All·Age: 18 - 100

Code: NCT06310031·Recruiting

Apply to this trial

Psychoeducational Intervention for Patients With Hepatocellular Carcinoma

for Hepatocellular Carcinoma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06541990·Recruiting

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A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i)

for Primary Myelofibrosis

13 locations incl. Palo Alto

Sponsor: Ajax Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06343805·Phase 1·Recruiting

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A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

for Carcinoma, Non-Small-Cell Lung

Drug: Intismeran autogene

48 locations incl. Gilbert

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06623422·Phase 3·Recruiting

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THRIVE-CAR-T Digital App

for CAR T-Cell Therapy

1 location in Boston

Sponsor: Patrick C. Johnson, MD

Sex: All·Age: 18+

Code: NCT06665295·Recruiting

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Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

for Pancreatic Ductal Adenocarcinoma

10 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT06562192·Phase 1·Recruiting

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Open-label Extension Study to Evaluate Metreleptin in Patients With Partial Lipodystrophy

for Familial Partial Lipodystrophy

7 locations incl. Birmingham

Sponsor: Amryt Pharma

Sex: All·Age: 13+

Code: NCT06679270·Phase 3·Recruiting

Apply to this trial

The CurePSP Genetics Program

for PSP

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 35+·Accepts healthy volunteers

Code: NCT06647641·Recruiting

Apply to this trial

REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities

for Coronary Artery Disease

18 locations incl. Glendale

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT06399705·Phase 3·Recruiting

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Soquelitinib vs Standard of Care in Participants With Relapsed/Refractory Peripheral T-cell Lymphoma Not Otherwise Specified, Follicular Helper T-cell Lymphomas, or Systemic Anaplastic Large-cell Lymphoma

for Peripheral T-Cell Lymphoma, Not Otherwise Specified

Drug: Soquelitinib

21 locations incl. Duarte

Sponsor: Corvus Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06561048·Phase 3·Recruiting

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Improving Health for Older Adults With Pain Through Engagement

for Chronic Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 55+

Code: NCT06119698·Recruiting

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Behavioral Economics to Implement a Traffic Light Nutrition Ranking System: Study 2

for Food Insecurity

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT06298253·Recruiting

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A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

for Breast Cancer

165 locations incl. Daphne

Sponsor: Stemline Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06492616·Phase 3·Recruiting

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Bionic Pancreas in CFRD

for Cystic Fibrosis-related Diabetes

16 locations incl. Aurora

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 14+

Code: NCT06449677·Phase 3·Recruiting

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Gastroparesis Registry 4

for Gastroparesis

6 locations incl. Scottsdale

Sponsor: Johns Hopkins Bloomberg School of Public Health

Sex: All·Age: 18 - 85

Code: NCT05846802·Recruiting

Apply to this trial

A Study of LY4050784 in Participants With Advanced or Metastatic Solid Tumors

for Metastatic Solid Tumor

17 locations incl. Santa Monica

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06561685·Phase 1·Recruiting

Apply to this trial