Clinical Trials at Massachusetts General Hospital

As of June 2026, 726 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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726 clinical trials at Massachusetts General Hospital

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Study of COYA 302 for the Treatment of ALS

for Amyotrophic Lateral Sclerosis (ALS)

21 locations incl. Phoenix

Sponsor: Coya Therapeutics

Sex: All·Age: 18 - 80

Code: NCT07161999·Phase 2·Recruiting

Apply to this trial

Imagined Acupuncture for Postoperative Pain After Spinal Surgery

for Pain Management

1 location in Boston

Sponsor: Jingping Wang, MD, Ph.D.

Sex: All·Age: 18+

Code: NCT07197710·Recruiting

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A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adults Diagnosed With IgG4-related Disease

for Immunoglobulin G4 Related Disease

17 locations incl. Fontana

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT07190196·Phase 3·Recruiting

Apply to this trial

Advanta VXT and Flixene PMCF Registry

for Peripheral Arterial Disease

1 location in Boston

Sponsor: Atrium Medical Corporation

Sex: All·Age: 18+

Code: NCT07161583·Recruiting

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A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

for Breast Cancer

14 locations incl. Orlando

Sponsor: Terremoto Biosciences Inc.

Sex: All·Age: 18+

Code: NCT07109726·Phase 1, Phase 2·Recruiting

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GORE® Ascending Stent Graft in the Treatment of De Novo Type A Aortic Dissections

for Aortic Dissection

16 locations incl. Birmingham

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06827990·Recruiting

Apply to this trial

BRIDGE: Blood Pressure Reduction and Intervention Delivery Via Group Engagement

for Stroke

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 35+

Code: NCT07091851·Recruiting

Apply to this trial

Pain Outcomes After Digital Amputation Using Tulavi Allay™ Nerve Cap

for Neuroma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 22+

Code: NCT06915662·Phase 2·Recruiting

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US Benchmarking Clinical Study

for HFpEF - Heart Failure With Preserved Ejection Fraction

3 locations incl. Boston

Sponsor: eMyosound SAS

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT07215715·Recruiting

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Web-based Mind-body Program to Improve Resilience Among Risky Substance Users With Persistent Upper Extremity Pain

for Orthopedic Disorder

1 location in Boston

Sponsor: Jafar Bakhshaie

Sex: All·Age: 18+

Code: NCT06991205·Recruiting

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Diet and Stress Management Combined With Advanced Therapy for Crohn's and Ulcerative Colitis

for IBD (Inflammatory Bowel Disease)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07168499·Recruiting

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Intent of Surgery for IPMN

for Intraductal Papillary Mucinous Neoplasm

8 locations incl. Phoenix

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT07216521·Recruiting

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Foundational Programs to Combat Clinician Stress

for Burnout, Professional

6 locations incl. Boston

Sponsor: Lancaster General Hospital

Sex: All·Age: 25 - 70·Accepts healthy volunteers

Code: NCT07220421·Recruiting

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A Study to Test Whether Nerandomilast Helps People With Lungfibrosis Related to Rheumatic Diseases

for Interstitial Lung Diseases

Drug: Nerandomilast

33 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06806592·Phase 3·Recruiting

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Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression

for Depression Disorders

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07082998·Recruiting

Apply to this trial

A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

for Breast Neoplasms

46 locations incl. Hot Springs

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06926868·Phase 2, Phase 3·Recruiting

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Assessment of the Feasibility of Using a Preoperative Surgical Fracture Analysis Tool

for Tibia Fractures

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT07193524·Recruiting

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A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease

for Colorectal Cancer

22 locations incl. Huntsville

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07023289·Phase 2·Recruiting

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CSB-321 Ph 1 in Immunotherapy for the Treatment of Cancer

for Metastatic Cancer

1 location in Boston

Sponsor: Cytosite Biopharma Inc.

Sex: All·Age: 18+

Code: NCT07057349·Phase 1·Not Yet Recruiting

Mindfulness-based Cognitive Therapy vs the Health Enhancement Program for Chronic Pain and Depression; The Quiet Focus Study

for Chronic Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50 - 120

Code: NCT07118722·Recruiting

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Online Parent Education for Child Anxiety

for Anxiety Disorders

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07153250·Recruiting

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Telerehabilitation In The Home After Stroke

for Stroke

27 locations incl. Downey

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 80

Code: NCT06682429·Recruiting

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AGENT DCB STANCE: Safety and Effectiveness Study of AGENT Drug-Coated Balloon Compared to Standard of Care Percutaneous Coronary Intervention (PCI) Treatment for de Novo Coronary Lesions

for Coronary Arterial Disease (CAD)

42 locations incl. La Jolla

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT06959524·Recruiting

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Towards Testing the Effectiveness of Recovery Community Centers (RCCs)

for Opioid Use Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07010978·Recruiting

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An Open-label Extension Safety Study of MELAS Patients Who Completed TIS6463-203 (PRIZM)

for Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)

9 locations incl. La Jolla

Sponsor: Tisento Therapeutics

Sex: All·Age: All ages

Code: NCT06961344·Phase 2·Enrolling By Invitation

A Study to Investigate the Efficacy, Safety, and Pharmacokinetics of Oral Rilzabrutinib Compared With Placebo in Participants 18 Years of Age and Older With Warm Autoimmune Hemolytic Anemia

for Autoimmune Haemolytic Anaemia

23 locations incl. Phoenix

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT07086976·Phase 3·Recruiting

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Study of NMS-03305293 in Adult Patient With Relapsed Small Cell Lung Cancer

for Small Cell Lung Cancer

2 locations incl. Boston

Sponsor: Nerviano Medical Sciences

Sex: All·Age: 18+

Code: NCT06931626·Phase 1·Recruiting

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ELISA in Relapsed/Refractory MM

for Relapsed Refractory Multiple Myeloma (RRMM)

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06832865·Phase 2·Recruiting

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A Follow-up Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

for Immune Thrombocytopenic Purpura (ITP)

17 locations incl. Los Angeles

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06948318·Phase 3·Recruiting

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Multidisciplinary Intervention for Adults With Chronic Graft-versus-host Disease

for Bone Marrow Transplant Complications

2 locations incl. Miami

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06910969·Recruiting

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Efgartigimod for the Treatment of Acute Optic Neuritis

for Optic Neuritis

2 locations incl. Boston

Sponsor: Anastasia Vishnevetsky, MD, MPH

Sex: All·Age: 18+

Code: NCT06453694·Phase 2·Recruiting

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A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors

for Advanced Solid Tumor

18 locations incl. Phoenix

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT07070232·Phase 1, Phase 2·Recruiting

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A Dose Randomization Study of Bulumtatug Fuvedotin in TNBC Patients Previously Treated With ADCs

for Triple Negative Breast Cancer

6 locations incl. Duarte

Sponsor: Mabwell (Shanghai) Bioscience Co., Ltd.

Sex: All·Age: 18+

Code: NCT06908928·Phase 1·Recruiting

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A Study of LY4257496 in Participants With Cancer (OMNIRAY)

for Breast Neoplasms

16 locations incl. Duarte

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07114601·Phase 1·Recruiting

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Facilitation of Extinction Retention and Reconsolidation Blockade by IV Allopregnanolone in PTSD.

for Post Traumatic Stress Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07079761·Phase 2·Recruiting

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Study Evaluating the Efficacy and Safety of Artesunate

for CMV Infection

2 locations incl. Boston

Sponsor: Amivas Inc.

Sex: All·Age: 18+

Code: NCT06853184·Phase 2·Recruiting

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AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors

for KRAS Altered Advanced or Metastatic Solid Tumors

9 locations incl. Duarte

Sponsor: Amgen

Sex: All·Age: 18+

Code: NCT07094113·Phase 1·Recruiting

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A Study of LY4175408 in Participants With Advanced Cancer

for Carcinoma, Non-Small-Cell Lung

Drug: LY4175408

15 locations incl. Stanford

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07046923·Phase 1·Recruiting

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ELEVATE High-Risk PCI Pivotal Study

for High-Risk Percutaneous Coronary Intervention (High-risk PCI)

29 locations incl. Scottsdale

Sponsor: Magenta Medical Ltd.

Sex: All·Age: 18 - 88

Code: NCT07001332·Recruiting

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A Long-Term Follow-Up Observational Study to Evaluate Safety in Subjects Who Have Received a Gene-Modified Regulatory T Cell (Treg) Therapeutic

for Rheumatoid Arthritis (RA)

10 locations incl. San Francisco

Sponsor: Sonoma Biotherapeutics, Inc.

Sex: All·Age: 18 - 71

Code: NCT07123038·Recruiting

Apply to this trial