Clinical Trials at Massachusetts General Hospital

As of June 2026, 726 paid clinical trials are recruiting at Massachusetts General Hospital, located at Faustman Lab at Massachusetts General Hospital, 149 13th St #3602, Boston, MA 02129, phone (617) 726-4084 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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726 clinical trials at Massachusetts General Hospital

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A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer

for Breast Neoplasms

25 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: Female·Age: 18+

Code: NCT07287098·Phase 2·Not Yet Recruiting

The Coma Family Program (COMA-F): A Resilience Program for Caregivers of Patients With Severe Acute Brain Injury

for Caregiver Distress

3 locations incl. Baltimore

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07331324·Not Yet Recruiting

A Nurse-Led, Coping and Supportive Intervention for Patients With Triple-Negative Breast Cancer

for Triple Negative Breast Cancer (TNBC)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07513311·Not Yet Recruiting

Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease

for Arginine Vasopressin Deficiency

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 7 - 21

Code: NCT07568509·EARLY_Phase 1·Recruiting

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A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk

for Atherosclerosis

Drug: Lepodisiran

17 locations incl. La Jolla

Sponsor: Eli Lilly and Company

Sex: All·Age: 45 - 80

Code: NCT07613294·Phase 3·Not Yet Recruiting

SAVE-Care (Sodium Glucose Cotransporter-2 Inhibitors [SGLT2i] As Novel Gout Care) Trial

for Gout and Hyperuricemia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT06674109·Phase 4·Recruiting

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Dapagliflozin in Active Lupus Nephritis

for Lupus Nephritis (LN)

Drug: Dapagliflozin

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 70

Code: NCT07323524·Phase 4·Recruiting

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PrP-targeting siRNA Safety & Mechanism Study

for Prion Disease

5 locations incl. Boston

Sponsor: Broad Institute of MIT and Harvard

Sex: All·Age: 18+

Code: NCT07444580·Phase 1·Recruiting

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Resiliency Intervention for Patients With ALS and Their Care-Partners

for Amyotrophic Lateral Sclerosis (ALS)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06968468·Not Yet Recruiting

Botensilimab, Balstilimab, and SBRT in Colorectal Cancer

for Non-MSI-H or pMMR Colorectal Cancer With Liver Metastasis

Drug: Botensilimab

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07128355·EARLY_Phase 1·Recruiting

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Study of INCA036978 in Participants With Myeloproliferative Neoplasms

for Myeloproliferative Neoplasms

Drug: INCA036978

22 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07441694·Phase 1·Recruiting

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Computer Guided Microwave Liver Ablation

for Hepatocellular Carcinoma (HCC)

2 locations incl. Boston

Sponsor: NE Scientific INC

Sex: All·Age: 18 - 90

Code: NCT07226869·Recruiting

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Falls Validation Study

for Intracranial Bleed

1 location in Boston

Sponsor: Dr. Kerstin de Wit

Sex: All·Age: 65+

Code: NCT07536906·Recruiting

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Pivotal Trial to Evaluate the Safety and Effectiveness of the P&F TricValve® Transcatheter Bicaval Valve System

for Tricuspid Valve Disease

35 locations incl. Birmingham

Sponsor: P+F Products + Features USA Inc.

Sex: All·Age: 18 - 85

Code: NCT06458907·Not Yet Recruiting

A Study to Investigate Lithium Brain/Plasma Pharmacokinetics and Safety of an AL001 Oral Capsule Compared to a Marketed Immediate-release Lithium Carbonate Capsule in Subjects With Bipolar I Disorder

for Bipolar I Disorder

1 location in Boston

Sponsor: Alzamend Neuro, Inc.

Sex: All·Age: 18 - 65

Code: NCT07540338·Phase 1, Phase 2·Recruiting

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Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression

for Treatment Resistant Depression (TRD)

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07563868·Recruiting

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Observational Study of Adults and Adolescents With Erythropoietic Protoporphyria (EPP) and X-linked Porphyria (XLP)

for Erythropoietic Protoporphyria (EPP)

5 locations incl. Boston

Sponsor: Portal Therapeutics, Inc.

Sex: All·Age: 12+

Code: NCT07567131·Recruiting

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Advanced Imaging to Assess the Effect of Immunosuppression on Progressive Fibrosis

for Interstitial Lung Disease

1 location in Boston

Sponsor: Peter Caravan

Sex: All·Age: 18 - 80

Code: NCT07572383·Phase 2·Recruiting

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Impact of Clinician-administered Vaginal Live Biotherapeutic Product

for Bacterial Vaginosis

1 location in Boston

Sponsor: Caroline Mitchell

Sex: Female·Age: 18 - 40

Code: NCT07305844·EARLY_Phase 1·Enrolling By Invitation

Phase 2 Study to Assess the Safety and Efficacy of ANG003

for Exocrine Pancreatic Insufficiency (EPI)

26 locations incl. Long Beach

Sponsor: Anagram Therapeutics, Inc.

Sex: All·Age: 12+

Code: NCT07450547·Phase 2·Recruiting

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A Study of LY4584180 in Adult Participants With Previously Treated Blood Cancers

for Lymphoma, Non-Hodgkin's

Drug: LY4584180

21 locations incl. Scottsdale

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07226843·Phase 1·Recruiting

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Effects of Resistance Exercise Among TGD Individuals Initiating Estrogen-Based Gender-Affirming Hormone Therapy

for Muscle Mass and Strength

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Male·Age: 18+

Code: NCT07400419·Recruiting

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ELDORADO: Elranatamab Versus Daratumumab in Combination With RVd Lite for Newly Diagnosed Transplant Ineligible/Deferred Multiple Myeloma

for Multiple Myeloma

Drug: Daratumumab

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07247097·Phase 2·Not Yet Recruiting

Remote Monitoring and Symptom Management Digital Application

for Breast Cancer (Locally Advanced or Metastatic)

1 location in Boston

Sponsor: Patrick C. Johnson, MD

Sex: All·Age: 18+

Code: NCT07553572·Recruiting

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Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)

for Atrial Fibrillation (AF)

22 locations incl. Birmingham

Sponsor: Medtronic Cardiac Ablation Solutions

Sex: All·Age: 18+

Code: NCT07298473·Recruiting

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A Study of VARIPULSE Pulsed Field Ablation (PFA) Catheter and FARAWAVE PFA Catheter in the Treatment of Participants With Persistent Atrial Fibrillation

for Atrial Fibrillation

11 locations incl. Jonesboro

Sponsor: Biosense Webster, Inc.

Sex: All·Age: 18 - 80

Code: NCT07523750·Recruiting

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Wearable Ultrasound Patch for Breast Imaging

for Breast Cancer

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 85·Accepts healthy volunteers

Code: NCT07186491·Not Yet Recruiting

Biomarker-based Trial of NPC-1 for Alzheimer's Pathology

for Alzheimer Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 55+

Code: NCT07236190·Phase 2·Recruiting

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NAD Augmentation to Prevent or Reverse Alzheimer's Disease in People With Down Syndrome

for Down Syndrome (DS)

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT07278492·Phase 1·Not Yet Recruiting

Setmelanotide to Treat Obesity in a Patient With Pseudohypoparathyroidism Type 1a (PHP1a)

for Pseudohypoparathyroidism Type 1a

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: All ages

Code: NCT07496463·Phase 2·Not Yet Recruiting

Phase 3 Trial of VMX-C001 vs Usual Pharmacological Care in Patients Taking a FXa Direct Oral Anticoagulant Who Require Urgent Surgery With or Without Heparin.

for Blood Loss, Surgical

16 locations incl. Chandler

Sponsor: VarmX B.V.

Sex: All·Age: 18+

Code: NCT07288489·Phase 3·Not Yet Recruiting

Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)

for Amyotrophic Lateral Sclerosis

3 locations incl. Sacramento

Sponsor: Paradromics

Sex: All·Age: 22 - 75

Code: NCT07357428·Recruiting

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Testing the Effectiveness of a Novel Intervention to Improve Medication Adherence in Stroke Survivors

for Stroke

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 99

Code: NCT07414732·Recruiting

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Thermal Measurements of the Gut With a Colonoscope Compatible Thermal Probe

for Inflammatory Bowel Diseases

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07352995·Enrolling By Invitation

Effects of IL-1 Beta Inhibition on Vascular Inflammation in TET2 Clonal Hematopoiesis

for Vascular Inflammation

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06691217·Phase 2·Recruiting

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Cardiac Effects of Mineralocorticoid Receptor Antagonism After Preeclampsia

for Hypertension

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 65

Code: NCT07238400·Phase 2·Recruiting

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CAIX PET/CT for Residual or Recurrent Post-ablative ccRCC

for Clear Cell Renal Cell Carcinoma (ccRCC)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07077083·Phase 2·Not Yet Recruiting

Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)

for Nicotine Dependence

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT07145866·Phase 4·Not Yet Recruiting

Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease

for Reproductive Disorder

1 location in Boston

Sponsor: Stephanie B. Seminara, MD

Sex: All·Age: 18 - 60

Code: NCT07224490·Phase 1·Recruiting

Apply to this trial

PDT For Induction Therapy For Head And Neck Cancer

for Squamous Cell Carcinoma

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07214987·Phase 2·Not Yet Recruiting