Clinical Trials at Brigham and Women's Hospital

As of June 2026, 366 paid clinical trials are recruiting at Brigham and Women's Hospital, located at 75 FRANCIS ST, BOSTON, MA 02115-6110, phone (617) 525-7104 in Boston, Massachusetts. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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366 clinical trials at Brigham and Women's Hospital

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J-Valve Transfemoral Pivotal Study

for Aortic Valve Regurgitation

34 locations incl. Scottsdale

Sponsor: JC Medical, Inc., an affiliate of Edwards Lifesciences LLC

Sex: All·Age: 18+

Code: NCT06455787·Recruiting

Apply to this trial

Effect of Physical Activity Pattern on Cardiometabolic Health

for Life Style

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05838508·Recruiting

Apply to this trial

Intraperitoneal Cytokine-Induced Memory Like (CIML) Natural Killer (NK) Cells in Recurrent Ovarian Cancer

for Platinum-resistant Ovarian Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18 - 85

Code: NCT06321484·Phase 1·Recruiting

Apply to this trial

Care Transitions App for Patients With Multiple Chronic Conditions

for Heart Failure

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT06051058·Recruiting

Apply to this trial

Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE Trial

for Breast Atypical Ductal Hyperplasia

11 locations incl. Tucson

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18 - 55

Code: NCT06184750·Phase 2·Recruiting

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ALPINE: Maintenance Letrozole/Abemaciclib

for Endometrial Cancer

6 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06366347·Phase 2·Recruiting

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A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy

for Drug Resistant Epilepsy

3 locations incl. Palo Alto

Sponsor: NaviFUS Corporation

Sex: All·Age: 18+

Code: NCT06388707·Phase 1, Phase 2·Recruiting

Apply to this trial

LIFT: Life Improvement Trial

for ME/CFS

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 70

Code: NCT06366724·Phase 2·Recruiting

Apply to this trial

Phase Ib Study of Axatilimab in Combination With Olaparib in BRCA1/2 and PALB2- Associated Metastatic HER2-negative Breast Cancer

for Breast Cancer

3 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06488378·Phase 1·Recruiting

Apply to this trial

AI Detection of Incidental Coronary Artery Calcium to Enhance Cardiovascular Disease Prevention

for Coronary Artery Disease

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 40 - 75

Code: NCT06235112·Recruiting

Apply to this trial

Exercise Training in Transthyretin Cardiac Amyloidosis

for Amyloid Cardiomyopathy

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 60 - 90

Code: NCT05797857·Recruiting

Apply to this trial

Understanding the Acute Pain Phenotype in Patients Undergoing Surgery

for Acute Pain

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06466941·Recruiting

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A Study of Assessment on Safety and Effectiveness of BWI Pulsed Field Ablation With OMNYPULSE Catheter for the Treatment of Paroxysmal Atrial Fibrillation (PAF)

for Atrial Fibrillation

43 locations incl. Phoenix

Sponsor: Biosense Webster, Inc.

Sex: All·Age: 18 - 80

Code: NCT06455098·Recruiting

Apply to this trial

Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

for Acute Respiratory Distress Syndrome

33 locations incl. Tucson

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06066502·Phase 3·Recruiting

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Randomized Trial of UI-EWD vs. Conventional Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Bleeding

for Acute Gastrointestinal Bleeding

7 locations incl. Birmingham

Sponsor: Medtronic - MITG

Sex: All·Age: 22+

Code: NCT06188585·Recruiting

Apply to this trial

Drug Screening Using IMD in Bladder Cancer

for Muscle Invasive Bladder Urothelial Carcinoma

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT06204614·EARLY_Phase 1·Enrolling By Invitation

Novel Treatments in Improving Renal Outcomes in Light Chain Cast Nephropathy

for Multiple Myeloma

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06483139·Recruiting

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BElumosudil for Bronchiolitis Obliterans Prevention/Therapy (BEBOP)

for Bronchiolitis Obliterans Syndrome

6 locations incl. Stanford

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT05922761·Phase 2·Recruiting

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CraniSeal Post Approval Study

for Leak, Cerebrospinal Fluid

8 locations incl. Los Angeles

Sponsor: Pramand LLC

Sex: All·Age: 18+

Code: NCT06406790·Phase 4·Recruiting

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A Study of Disitamab Vedotin With Other Anticancer Drugs in Solid Tumors

for Breast Neoplasms

82 locations incl. Tucson

Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All·Age: 18+

Code: NCT06157892·Phase 2·Recruiting

Apply to this trial

VE303 for Prevention of Recurrent Clostridioides Difficile Infection

for Clostridium Difficile

84 locations incl. Huntsville

Sponsor: Vedanta Biosciences, Inc.

Sex: All·Age: 12+

Code: NCT06237452·Phase 3·Recruiting

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Subclinical Primary Aldosteronism in Diabetes At-Risk for Kidney Disease

for Type 2 Diabetes

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 80

Code: NCT06190158·EARLY_Phase 1·Recruiting

Apply to this trial

Ergonomics in the Cardiac Catheterization Laboratory

for Ergonomics

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06506968·Recruiting

Apply to this trial

Adult Sleep Health in the Rural Appalachia and Mississippi Delta Region and Its Relationships With Cardiometabolic Health Disparities.

for Sleep Apnea

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 25 - 65

Code: NCT06336525·Enrolling By Invitation

Polygenic Risk Stratification Combined With mpMRI to Identify Clinically Relevant Prostate Cancer

for Prostate Cancer

5 locations incl. Washington D.C.

Sponsor: Adam S. Kibel, MD

Sex: Male·Age: 40 - 69·Accepts healthy volunteers

Code: NCT06398639·Recruiting

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Preventing Injured Knees From osteoArthritis: Severity Outcomes

for Osteoarthritis, Knee

9 locations incl. Atlanta

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 45

Code: NCT06096259·Phase 2·Recruiting

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A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast

for Idiopathic Pulmonary Fibrosis

Drug: Nerandomilast

58 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06238622·Phase 3·Recruiting

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A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)

for Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

33 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 12+

Code: NCT06338995·Phase 3·Recruiting

Apply to this trial

A Registry Based Collaborative to Measure Efficiency, Effectiveness, and Safety of Farapulse PFA Technology for AF

for Atrial Fibrillation

35 locations incl. Birmingham

Sponsor: Heart Rhythm Clinical and Research Solutions, LLC

Sex: All·Age: 18+

Code: NCT06335082·Enrolling By Invitation

A Study to Evaluate TAR-210 Versus Single Agent Intravesical Cancer Treatment in Participants With Bladder Cancer

for Non-Muscle Invasive Bladder Neoplasms

38 locations incl. Little Rock

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06319820·Phase 3·Recruiting

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IMPRoving Outcomes in Vascular DisEase - Aortic Dissection

for Type B Aortic Dissection

61 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT06087029·Recruiting

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A Hybrid Effectiveness Implementation Trial Evaluating Behavioral Treatments for Insomnia for Socioeconomically Disadvantaged Adults in Primary Care

for Insomnia

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05759065·Recruiting

Apply to this trial

Digital Health Navigation for Latino Patients With Type II Diabetes

for Type 2 Diabetes

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06283992·Recruiting

Apply to this trial

Resistance and Aerobic Exercise for Prevention in Women With Dense Breasts (REP-D)

for Breast Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 18 - 59·Accepts healthy volunteers

Code: NCT06322888·Recruiting

Apply to this trial

Reversible Effect of Falling Ventilatory Drive in Drive-dependent OSA

for OSA

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 21 - 80

Code: NCT06091098·Recruiting

Apply to this trial

Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC

for Arrhythmogenic Right Ventricular Cardiomyopathy

7 locations incl. San Francisco

Sponsor: Tenaya Therapeutics

Sex: All·Age: 18 - 65

Code: NCT06228924·Phase 1·Recruiting

Apply to this trial

The Osteoarthritis Prevention Study

for Osteoarthritis, Knee

3 locations incl. Boston

Sponsor: Wake Forest University

Sex: Female·Age: 50+·Accepts healthy volunteers

Code: NCT05946044·Recruiting

Apply to this trial

Strategy for Improving Stroke Treatment Response

for Ischemic Stroke

52 locations incl. Birmingham

Sponsor: Translational Sciences, Inc.

Sex: All·Age: 18+

Code: NCT05948566·Phase 2·Recruiting

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A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

for Diabetes Mellitus, Type 2

124 locations incl. Chandler

Sponsor: Cleerly, Inc.

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT06112418·Recruiting

Apply to this trial

Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis

for Rheumatoid Arthritis

8 locations incl. Scottsdale

Sponsor: Sonoma Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT06201416·Phase 1·Recruiting

Apply to this trial