Depression Clinical Trials in Boston, MA

As of June 2026, 55 paid clinical trials are recruiting for Depression in Boston, Massachusetts. Depression studies test rapid-acting antidepressants including ketamine derivatives, psilocybin-assisted therapy, and neuromodulation approaches. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

Related specialties in Boston

Behavioral health· 163 Mental health· 141 Psychiatry· 129

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Healthy volunteers only

55 clinical trials for Depression

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Toward Understanding Drivers of Patient Engagement With Digital Mental Health Interventions - Part II

for Depression

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 75

Code: NCT05555875·Recruiting

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Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33

for Major Depressive Disorder

3 locations incl. Boston

Sponsor: NYU Langone Health

Sex: All·Age: 18 - 65

Code: NCT05573074·Recruiting

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Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV

for Major Depressive Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85

Code: NCT05570812·Phase 2·Recruiting

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Effectiveness of Interventions to Improve Resiliency & Burnout in Behavioral Health Residential Staff

for Burnout

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05806112·Enrolling By Invitation

Training in Evidence-based Treatments in Psycho-Oncology

for Distress, Emotional

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05674357·Recruiting

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Peripheral Neuroimmune Mechanisms of Hyperthermia

for Hyperthermia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT05366270·Recruiting

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Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression

for Major Depressive Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 70

Code: NCT05450432·Phase 4·Recruiting

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Modulating Exercise Dosage to Improve Concussion Recovery

for Concussion, Brain

3 locations incl. Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 13 - 18

Code: NCT05434130·Phase 2·Recruiting

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Cannabidiol for Reduction of Brain Neuroinflammation

for Back Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75

Code: NCT05066308·Phase 2·Recruiting

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Triage Survey for Psychiatry Research Eligibility

for Major Depressive Disorder

6 locations incl. Boston

Sponsor: Adams Clinical

Sex: All·Age: 18+

Code: NCT05800925·Recruiting

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Buspirone and Melatonin for Depression Following Traumatic Brain Injury

for Depression

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 64

Code: NCT04400266·Phase 4·Recruiting

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Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder

for Major Depressive Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT03748446·EARLY_Phase 1·Recruiting

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A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

for Treatment Resistant Depression

98 locations incl. Birmingham

Sponsor: LivaNova

Sex: All·Age: 18+

Code: NCT03887715·Recruiting

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Brain Connectivity in Depression

for Depression

4 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT03276793·Recruiting

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Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

for Traumatic Brain Injury

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT04296604·Recruiting

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