Clinical Trials at Johns Hopkins Hospital

As of June 2026, 138 paid clinical trials are recruiting at Johns Hopkins Hospital, located at JOHNS HOPKINS DEPARTMENT OF SURGERY, 600 N WOLFE ST TOWER 110, BALTIMORE, MD 21287-0001, phone (410) 955-5020 in Baltimore, Maryland. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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138 clinical trials at Johns Hopkins Hospital

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A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia

for Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands

18 locations incl. Gilbert

Sponsor: MeiraGTx, LLC

Sex: All·Age: 18+

Code: NCT05926765·Phase 2·Recruiting

Apply to this trial

REpeated ASSEssment of SurvivorS in Intracerebral Hemorrhage Study

for Intra Cerebral Hemorrhage

26 locations incl. Birmingham

Sponsor: Johns Hopkins University

Sex: All·Age: All ages

Code: NCT05611918·Enrolling By Invitation

Cognitive Outcomes After Brain Substructure-informed Radiation Planning in Pediatric Patients

for Brain Tumor

2 locations incl. Washington D.C.

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All·Age: 1 - 26·Accepts healthy volunteers

Code: NCT05658731·Recruiting

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Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progression in Participants With Bilateral Lung Transplant

for Pre-Bronchiolitis Obliterans Syndrome

20 locations incl. Phoenix

Sponsor: Renovion, Inc.

Sex: All·Age: 18 - 75

Code: NCT05654922·Phase 3·Recruiting

Apply to this trial

Distal Radius Interventions for Fracture Treatment

for Fracture Distal Radius

25 locations incl. Phoenix

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 4 - 10

Code: NCT05131685·Recruiting

Apply to this trial

Targeting Cognition in Early Alzheimer's Disease by Improving Sleep With Trazodone

for AMCI - Amnestic Mild Cognitive Impairment

1 location in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 55+

Code: NCT05282550·Phase 2·Recruiting

Apply to this trial

Study of Healthy Cohort for Early Detection of Cancer

for Healthy

1 location in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT05193305·Recruiting

Apply to this trial

Gender Related Coping and Survivorship for Genitourinary Cancers

for Bladder Cancer

2 locations incl. Washington D.C.

Sponsor: Johns Hopkins University

Sex: Female·Age: 18+

Code: NCT05649306·Recruiting

Apply to this trial

Rectal Indomethacin and Oral Tacrolimus Versus Combination to Prevent Post-ERCP Pancreatitis

for Post-ERCP Acute Pancreatitis

1 location in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT05252754·Phase 3·Recruiting

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Predicting Outcomes in Hypoglossal Nerve Stimulation Therapy With Stimulated Upper Airway Mechanics

for Sleep Apnea, Obstructive

1 location in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT05429983·Recruiting

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Targeting Language-specific and Executive-control Networks With Transcranial Direct Current Stimulation in Logopenic Variant PPA

for Logopenic Progressive Aphasia

1 location in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 50 - 80·Accepts healthy volunteers

Code: NCT03887481·Recruiting

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A Study to Evaluate the Efficacy, Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Satralizumab in Participants With Anti-N-methyl-D-aspartic Acid Receptor (NMDAR) or Anti-leucine-rich Glioma-inactivated 1 (LGI1) Encephalitis

for NMDAR Autoimmune Encephalitis

20 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 12+

Code: NCT05503264·Phase 3·Recruiting

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Multicenter Trial Evaluating the Safety and Efficacy of Autologous Volar Fibroblast Injection Into the Terminal Limb of Amputees.

for Amputation

1 location in Baltimore

Sponsor: Major Extremity Trauma Research Consortium

Sex: All·Age: 18 - 75

Code: NCT04839497·Phase 2·Recruiting

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Efficacy and Safety Study of Nipocalimab for Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

for Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

Drug: Nipocalimab

14 locations incl. Centennial

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05327114·Phase 2, Phase 3·Recruiting

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Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V

for Lupus Nephritis

26 locations incl. Phoenix

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT05268289·Phase 2·Recruiting

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Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children

for Child

11 locations incl. Madera

Sponsor: Johns Hopkins University

Sex: All·Age: Up to 18

Code: NCT04989790·Recruiting

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Cooperative Assessment of Late Effects for SCD Curative Therapies

for Sickle Cell Disease

5 locations incl. Washington D.C.

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 4 - 65

Code: NCT05153967·Recruiting

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Intraoperative Radiation Therapy After Stereotactic Body Radiation Therapy and Chemotherapy in Treatment of Pancreatic Adenocarcinoma

for Pancreatic Cancer

1 location in Baltimore

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All·Age: 18+

Code: NCT05141513·Phase 1·Recruiting

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Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults

for Seizures

Drug: Carisbamate

22 locations incl. Palo Alto

Sponsor: SK Life Science, Inc.

Sex: All·Age: 4 - 55

Code: NCT05219617·Phase 3·Recruiting

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Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive Decline

for Ischemic Stroke

1 location in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT05556395·Recruiting

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4D-710 in Adult Patients With Cystic Fibrosis

for Cystic Fibrosis Lung

20 locations incl. Birmingham

Sponsor: 4D Molecular Therapeutics

Sex: All·Age: 18+

Code: NCT05248230·Phase 2·Recruiting

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EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe Disease

for COVID-19

50 locations incl. Phoenix

Sponsor: Pfizer

Sex: All·Age: 0 - 17

Code: NCT05261139·Phase 3·Recruiting

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Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC)

for Pruritus

Drug: Dupilumab

18 locations incl. Bakersfield

Sponsor: Sanofi

Sex: All·Age: 18 - 90

Code: NCT05263206·Phase 3·Recruiting

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Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD

for AMD

107 locations incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: 50 - 89

Code: NCT05407636·Phase 3·Recruiting

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Full-Field Optical Coherence Tomography (FFOCT) for Evaluation of Bronchoscopic Small Biopsy Specimens

for Lung Cancer

1 location in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT05171478·Recruiting

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Transrectal Ultrasound Robot-Assisted Prostate Biopsy

for Prostate Cancer

1 location in Baltimore

Sponsor: Johns Hopkins University

Sex: Male·Age: 45 - 75

Code: NCT02871726·Recruiting

Apply to this trial

Cerebellar Stimulation for Aphasia Rehabilitation

for Stroke

1 location in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 18 - 99

Code: NCT05093673·Recruiting

Apply to this trial

Long-term Safety and Efficacy of Odevixibat in Patients With Alagille Syndrome

for Alagille Syndrome

18 locations incl. San Diego

Sponsor: Albireo, an Ipsen Company

Sex: All·Age: All ages

Code: NCT05035030·Phase 3·Recruiting

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Study of Efficacy and Safety of Iptacopan in Patients With C3 Glomerulopathy.

for C3G

Drug: Iptacopan

13 locations incl. Aurora

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 12 - 60

Code: NCT04817618·Phase 3·Recruiting

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Trial of Therapeutic Hypothermia in Patients With ARDS

for Respiratory Distress Syndrome, Adult

19 locations incl. Los Angeles

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18 - 85

Code: NCT04545424·Phase 2·Recruiting

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ROSE for Improved Molecular Marker Testing Via EBUS

for Non-small Cell Lung Cancer (NSCLC)

4 locations incl. Chicago

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT04945317·Enrolling By Invitation

A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

for Low-grade Glioma

14 locations incl. San Francisco

Sponsor: Day One Biopharmaceuticals, Inc.

Sex: All·Age: 6 Months - 25

Code: NCT04775485·Phase 2·Recruiting

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Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors

for Advanced Solid Tumor Cancer

Drug: ABBV-CLS-484

15 locations incl. Tucson

Sponsor: Calico Life Sciences LLC

Sex: All·Age: 18+

Code: NCT04777994·Phase 1·Recruiting

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Ketogenic Diet for New-Onset Absence Epilepsy

for Absence Epilepsy

1 location in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 3 - 12

Code: NCT04274179·Phase 3·Recruiting

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Innovative Trial for Understanding the Impact of Targeted Therapies in NF2-Related Schwannomatosis (INTUITT-NF2)

for Neurofibromatosis Type 2

6 locations incl. Los Angeles

Sponsor: Scott R. Plotkin, MD, PhD

Sex: All·Age: 12+

Code: NCT04374305·Phase 2·Recruiting

Apply to this trial

The Impact of COVID-19 on Maternal and Neonatal Outcomes

for COVID-19

1 location in Baltimore

Sponsor: Johns Hopkins University

Sex: Female·Age: 14 - 55·Accepts healthy volunteers

Code: NCT05197621·Recruiting

Apply to this trial

Proton Radiation Therapy Registry

for Cancer, Therapy-Related

4 locations incl. Washington D.C.

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All·Age: 18 - 100

Code: NCT04376229·Recruiting

Apply to this trial

Noraxon myoRESEARCH™ Software Gait Analysis Evaluation and Orthotic Gait Correction in Reducing Diabetic Foot Ulceration Or Subsequent Amputation in Patients With a History of a Diabetic Foot Ulceration

for Diabetic Foot Ulcer

1 location in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 18 - 90

Code: NCT04164641·Recruiting

Apply to this trial

Skeletal Muscle Energetics and Fatiguability in Older Individuals

for HIV

1 location in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 60 - 90·Accepts healthy volunteers

Code: NCT04142047·Recruiting

Apply to this trial

Patient Reported Outcomes for Vascular Malformations EmbolizatioN (PROVEN)

for Vascular Malformations

1 location in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 0 - 100

Code: NCT04104464·Recruiting

Apply to this trial