NNC0487-0111 Clinical Trials (2026): 17 Studies for Obesity & Overweight
Hipa.ai Research · Source: ClinicalTrials.gov / AACT
Synced daily from ClinicalTrials.gov via AACT. Last sync: .
17 NNC0487-0111 clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 5 indications (including Obesity & Overweight) and 5,416 total planned enrollment. 6 Phase 3 NNC0487-0111 trials and 2 Phase 2 are listed. 8 NNC0487-0111 clinical trials are actively recruiting at 83 U.S. sites across 25 states. Most recent activity: NCT07339423 (Aug 2029).
Where to Participate: All NNC0487-0111 Trial Sites in the U.S. (83 sites across 25 states)
Every actively recruiting NNC0487-0111trial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.
| State | Facility | City | Trial | Map |
|---|---|---|---|---|
| AL | Pinnacle Research Group LLC | Anniston36207 | NCT07503210 | Map |
| AL | Univ of Alabama Birmingham | Birmingham35294 | NCT07533175 | Map |
| AZ | Arizona Research Center, Inc. | Phoenix85053 | NCT07481630 | Map |
| CA | Headlands Research California, LLC | Escondido92025 | NCT07533175 | Map |
| CA | Neighborhood Healthcare | Escondido92025 | NCT07509307 | Map |
| CA | First Valley Medical Group | Lancaster93534 | NCT07509307 | Map |
| CA | Torrance Clinical Research Institute, Inc. | Lomita90717 | NCT07533175 | Map |
| CA | Desert Oasis Healthcare | Palm Springs92262 | NCT07509307 | Map |
| CA | Diablo Clinical Research, Inc. | Walnut Creek94598 | NCT07481630 | Map |
| CA | Diablo Clinical Research, Inc. | Walnut Creek94598 | NCT07503210 | Map |
| CA | Diablo Clinical Research, Inc. | Walnut Creek94598 | NCT07533175 | Map |
| CT | Chase Medical Research LLC | Hamden06517 | NCT07481630 | Map |
| CT | Chase Medical Research LLC | Waterbury06708 | NCT07481630 | Map |
| CT | Chase Medical Research LLC | Waterbury06708 | NCT07509307 | Map |
| FL | Northeast Research Institute | Fleming Island32003 | NCT07533175 | Map |
| FL | Zenith clinical research | Hollywood33021 | NCT07481630 | Map |
| FL | CNS Healthcare | Jacksonville32256 | NCT07481630 | Map |
| FL | CNS Healthcare | Jacksonville32256 | NCT07509307 | Map |
| FL | Jacksonville Ctr Clin Res | Jacksonville32216 | NCT07533175 | Map |
| FL | Westside Center For Clinical Research | Jacksonville32205 | NCT07509307 | Map |
| FL | Angels Clinical Research Institute | Miami Lakes33016 | NCT07481630 | Map |
| FL | South Broward Research LLC | Miramar33027 | NCT07339423 | Map |
| FL | Advanced Res for Health Improve | Naples34102 | NCT07509307 | Map |
| FL | Clinical Neuroscience Solution | Orlando32801 | NCT07339423 | Map |
| FL | Florida Inst For Clin Res LLC | Orlando32825 | NCT07503210 | Map |
| FL | Florida Institute for Clinical Research, LLC | Orlando32825 | NCT07533175 | Map |
| FL | Oviedo Medical Research, LLC | Oviedo32765 | NCT07533175 | Map |
| GA | Hope Clin Res & Wellness | Conyers30094 | NCT07339423 | Map |
| GA | Hope Clin Res & Wellness | Conyers30094 | NCT07481630 | Map |
| GA | CenExel iResearch, LLC | Decatur30030 | NCT07481630 | Map |
| ID | Elite Clinical Trials | Blackfoot83221 | NCT07481630 | Map |
| IL | Clinical Investigation Spec Gurnee | Gurnee60031 | NCT07509307 | Map |
| IL | Endeavor Health | Skokie60077 | NCT07339423 | Map |
| IL | Evanston Premier Hlthcr Res | Skokie60077 | NCT07509307 | Map |
| IN | Midwest Inst For Clin Res | Indianapolis46260 | NCT07339423 | Map |
| IN | Midwest Inst For Clin Res | Indianapolis46260 | NCT07503210 | Map |
| KY | Monroe Biomedical Research, LLC | Louisville40213 | NCT07509307 | Map |
| MA | MedVadis Research Watertown | Waltham02451 | NCT07481630 | Map |
| MI | Arcturus Healthcare, PLC. | Troy48098-6368 | NCT07509307 | Map |
| MN | International Diabetes Center | Minneapolis55416 | NCT07533175 | Map |
| MO | StudyMetrix Research LLC | City of Saint Peters63303 | NCT07339423 | Map |
| MO | Clinvest Research | Springfield65807 | NCT07509307 | Map |
| NV | Jubilee Clinical Research, Inc. | Las Vegas89106 | NCT07481630 | Map |
| NY | New York Gastroenterology Associates | New York10075 | NCT07339423 | Map |
| NY | Southgate Medical Group, LLP | West Seneca14224 | NCT07533175 | Map |
| NY | Great Lakes Medical Research | Westfield14787 | NCT07481630 | Map |
| NC | UNC Eastowne Medical Office | Chapel Hill27514 | NCT07339423 | Map |
| NC | Medication Mgmnt, LLC_Grnsboro | Greensboro27405 | NCT07503210 | Map |
| NC | PharmQuest Life Sciences LLC | Greensboro27408 | NCT07339423 | Map |
| NC | Piedmont Healthcare/Research | Statesville28625 | NCT07509307 | Map |
| NC | Accellacare and KDCILM, LLC | Wilmington28401 | NCT07339423 | Map |
| NC | Accellacare and KDCILM, LLC | Wilmington28401 | NCT07481630 | Map |
| NC | PMG Research of Wilmington LLC | Wilmington28401 | NCT07503210 | Map |
| OR | Northwest Research Center | Portland97202 | NCT07509307 | Map |
| PA | UPA Ctr Weight and Eating Dis | Philadelphia19104 | NCT07339423 | Map |
| PA | UPA Ctr Weight and Eating Dis | Philadelphia19104 | NCT07503210 | Map |
| RI | Clinical Res Collaborative | Cumberland02864 | NCT07339423 | Map |
| RI | Clinical Res Collaborative | Cumberland02864 | NCT07503210 | Map |
| SC | Medical Uni of SC Charleston | Charleston29425 | NCT07339423 | Map |
| SC | Coastal Carolina Res Ctr | North Charleston29405 | NCT07481630 | Map |
| SC | Coastal Carolina Research Ctr | North Charleston29405 | NCT07339423 | Map |
| SC | Hillcrest Clinical Research | Simpsonville29681-1538 | NCT07339423 | Map |
| SC | Spartanburg Medical Research | Spartanburg29303 | NCT07533175 | Map |
| TN | M3 Wake Research Chattanooga | Chattanooga37421 | NCT07533175 | Map |
| TX | Amarillo Medical Specialists | Amarillo79124 | NCT07339423 | Map |
| TX | UT Southwestern Med Cntr | Dallas75390-9302 | NCT07503210 | Map |
| TX | UT Southwestern Medical Center - Lingvay | Dallas75390 | NCT07533175 | Map |
| TX | Velocity Clinical Res-Dallas | Dallas75230-6855 | NCT07339423 | Map |
| TX | Care United Research, LLC | Forney75126 | NCT07339423 | Map |
| TX | PlanIt Research, PLLC | Houston77079 | NCT07533175 | Map |
| TX | VIP Trials_San Antonio | San Antonio78230 | NCT07481630 | Map |
| VA | Washington Cntr Weight Mgmt | Arlington22206 | NCT07339423 | Map |
| VA | Charlottesville Med Research | Charlottesville22911 | NCT07481630 | Map |
| VA | Health Res of Hampton Roads | Newport News23606 | NCT07339423 | Map |
| VA | Health Res of Hampton Roads | Newport News23606 | NCT07481630 | Map |
| VA | Health Res of Hampton Roads | Newport News23606 | NCT07509307 | Map |
| VA | National Clin Res Inc. | Richmond23294 | NCT07533175 | Map |
| VA | Selma Medical Associates | Winchester22601-3834 | NCT07339423 | Map |
| VA | Selma Medical Associates | Winchester22601-3834 | NCT07503210 | Map |
| WA | Northwest Clinical Research Center | Bellevue98007 | NCT07481630 | Map |
| WA | Northwest Clinical Research Center | Bellevue98007 | NCT07509307 | Map |
| WA | Rainier Clin Res Ctr Inc | Renton98057 | NCT07339423 | Map |
| WA | Rainier Clin Res Ctr Inc | Renton98057 | NCT07503210 | Map |
NNC0487-0111 clinical trials at a glance: phase × recruitment status
| Phase | recruiting | completed | not yet recruiting | Total |
|---|---|---|---|---|
| P1 | 2 | 7 | 9 | |
| P2 | 2 | 2 | ||
| P3 | 5 | 1 | 6 |
Recruiting NNC0487-0111 clinical trials (8)
Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).
| NCT ID | Title | Phase | Indication | Enrollment | Started |
|---|---|---|---|---|---|
| NCT07339423 | AMAZE 1AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight | P3 | Obesity | 1,150 | Feb 2026 |
| NCT07400107 | AMAZE 8AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight | P3 | Obesity | 1,000 | May 2026 |
| NCT07481630 | AMAZE 5A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain | P3 | Obesity | 400 | Apr 2026 |
| NCT07509307 | AMAZE 6AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain | P3 | Obesity | 400 | Apr 2026 |
| NCT07533175 | AMAZE 2AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight | P3 | Diabetes Mellitus | 630 | Apr 2026 |
| NCT07503210 | AMAZE 12AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss | P3 | Obesity | 600 | Apr 2026 |
| NCT07508020 | A Research Study Looking at How NNC0487-0111 Affects Food Intake, Appetite and Metabolism After Meals in People With Obesity | P1 | Obesity | 120 | Mar 2026 |
| NCT07535307 | Investigating How NNC0487-0111 Regulates Insulin of Adults With Type 2 Diabetes | P1 | Diabetes Mellitus | 80 | Apr 2026 |
NNC0487-0111 clinical trials by indication
Obesity (11)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07339423 | AMAZE 1 | P3 | recruiting | AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight |
| NCT07400107 | AMAZE 8 | P3 | not yet recruiting | AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight |
| NCT07481630 | AMAZE 5 | P3 | recruiting | A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain |
| NCT07509307 | AMAZE 6 | P3 | recruiting | AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain |
| NCT07503210 | AMAZE 12 | P3 | recruiting | AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss |
| NCT07508020 | — | P1 | recruiting | A Research Study Looking at How NNC0487-0111 Affects Food Intake, Appetite and Metabolism After Meals in People With Obesity |
| NCT06478563 | — | P1 | completed | A Research Study Looking at Different Oral Formulations and the Effect of Food Intake on How the Medicine NNC0487-0111 Behaves in the Body of Participants Living With Overweight or Obesity |
| NCT06461039 | — | P1 | completed | A Research Study Looking at How the Compound NNC0487-0111 Works With Birth Control Pills and Affects Emptying of the Stomach in Women Not Able to Become Pregnant |
| + 3 more, see All trials below. | ||||
Diabetes Mellitus (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07533175 | AMAZE 2 | P3 | recruiting | AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight |
| NCT07535307 | — | P1 | recruiting | Investigating How NNC0487-0111 Regulates Insulin of Adults With Type 2 Diabetes |
Overweight (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07121153 | — | P1 | completed | A Research Study on How NNC0487-0111, a New Medicine, Works in Chinese Participants When Injected Under the Skin. |
| NCT06820476 | — | P1 | completed | A Research Study on How NNC0487-0111, a New Medicine, Works in Chinese Participants After 10 Days of Oral Dosing |
Diabetes Mellitus, Type 2 (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06559527 | — | P1 | completed | A Research Study Looking Into Blood Levels of the Medicine NNC0487-0111 in the Body and How Well it is Tolerated in Participants With Reduced Kidney Function and Normal Kidney Function |
Type 2 Diabetes (T2D) (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06542874 | — | P2 | completed | A Research Study Comparing How Well Different Doses of the Medicine NNC0487-0111 Lower Blood Sugar in People With Type 2 Diabetes |
NNC0487-0111 pivotal trial highlights (Phase 2/3/4)
Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.
| Acronym | NCT | Phase | Status | Indication | Enrollment | PubMed |
|---|---|---|---|---|---|---|
| AMAZE 1 | NCT07339423 | P3 | recruiting | Obesity | 1,150 | — |
| AMAZE 8 | NCT07400107 | P3 | not yet recruiting | Obesity | 1,000 | — |
| AMAZE 5 | NCT07481630 | P3 | recruiting | Obesity | 400 | — |
| AMAZE 6 | NCT07509307 | P3 | recruiting | Obesity | 400 | — |
| AMAZE 2 | NCT07533175 | P3 | recruiting | Diabetes Mellitus | 630 | — |
| AMAZE 12 | NCT07503210 | P3 | recruiting | Obesity | 600 | — |
| NNC0487-0111 | NCT06064006 | P2 | completed | Obesity | 125 | — |
All NNC0487-0111 trials (17)
Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.
| NCT ID | Acronym | Title | Phase | Status | Enrollment | Sponsor | Started |
|---|---|---|---|---|---|---|---|
| NCT07339423 | AMAZE 1 | AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight | P3 | recruiting | 1,150 | Novo Nordisk A/S | Feb 2026 |
| NCT07400107 | AMAZE 8 | AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight | P3 | not yet recruiting | 1,000 | Novo Nordisk A/S | May 2026 |
| NCT07481630 | AMAZE 5 | A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain | P3 | recruiting | 400 | Novo Nordisk A/S | Apr 2026 |
| NCT07509307 | AMAZE 6 | AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain | P3 | recruiting | 400 | Novo Nordisk A/S | Apr 2026 |
| NCT07533175 | AMAZE 2 | AMAZE 2: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight | P3 | recruiting | 630 | Novo Nordisk A/S | Apr 2026 |
| NCT07503210 | AMAZE 12 | AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss | P3 | recruiting | 600 | Novo Nordisk A/S | Apr 2026 |
| NCT07508020 | A Research Study Looking at How NNC0487-0111 Affects Food Intake, Appetite and Metabolism After Meals in People With Obesity | P1 | recruiting | 120 | Novo Nordisk A/S | Mar 2026 | |
| NCT07535307 | Investigating How NNC0487-0111 Regulates Insulin of Adults With Type 2 Diabetes | P1 | recruiting | 80 | Novo Nordisk A/S | Apr 2026 | |
| NCT07121153 | A Research Study on How NNC0487-0111, a New Medicine, Works in Chinese Participants When Injected Under the Skin. | P1 | completed | 36 | Novo Nordisk A/S | Aug 2025 | |
| NCT06542874 | A Research Study Comparing How Well Different Doses of the Medicine NNC0487-0111 Lower Blood Sugar in People With Type 2 Diabetes | P2 | completed | 448 | Novo Nordisk A/S | Aug 2024 | |
| NCT06478563 | A Research Study Looking at Different Oral Formulations and the Effect of Food Intake on How the Medicine NNC0487-0111 Behaves in the Body of Participants Living With Overweight or Obesity | P1 | completed | 133 | Novo Nordisk A/S | Jun 2024 | |
| NCT06820476 | A Research Study on How NNC0487-0111, a New Medicine, Works in Chinese Participants After 10 Days of Oral Dosing | P1 | completed | 29 | Novo Nordisk A/S | Feb 2025 | |
| NCT06461039 | A Research Study Looking at How the Compound NNC0487-0111 Works With Birth Control Pills and Affects Emptying of the Stomach in Women Not Able to Become Pregnant | P1 | completed | 43 | Novo Nordisk A/S | Jun 2024 | |
| NCT06559527 | A Research Study Looking Into Blood Levels of the Medicine NNC0487-0111 in the Body and How Well it is Tolerated in Participants With Reduced Kidney Function and Normal Kidney Function | P1 | completed | 42 | Novo Nordisk A/S | Aug 2024 | |
| NCT06064006 | NNC0487-0111 | A Research Study to See How a New Medicine (NNC0487-0111) Works in People With Overweight or Obesity When Injected Under the Skin | P2 | completed | 125 | Novo Nordisk A/S | Sep 2023 |
| NCT05369390 | A Research Study on How NNC0487-0111 Works in People With Overweight or Obesity | P1 | completed | 144 | Novo Nordisk A/S | May 2022 | |
| NCT06049329 | A Research Study of How a New Medicine Called Amycretin, Given as Tablets, Works in Japanese Men With Obesity | P1 | completed | 36 | Novo Nordisk A/S | Sep 2023 |
NNC0487-0111 clinical trials: frequently asked questions
- How many NNC0487-0111 clinical trials are there?
- 17 NNC0487-0111 clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 7 are actively recruiting participants. 9 are marked completed.
- Are NNC0487-0111 clinical trials recruiting in 2026?
- Yes — 7 NNC0487-0111 trials are actively recruiting in 2026, with 83 U.S. sites across 25 states. See the recruiting trials and the per-state site list further down this page.
- What conditions is NNC0487-0111 being studied for?
- NNC0487-0111 is being studied for Obesity, Overweight, Diabetes Mellitus, Type 2, Diabetes Mellitus, Knee Osteoarthritis (OA) and 2 more. The trials are grouped by indication on this page.
- What phase is NNC0487-0111 in?
- NNC0487-0111 clinical trials span 6 Phase 3, 2 Phase 2, 9 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
- Who sponsors NNC0487-0111 clinical trials?
- The lead sponsor across the most NNC0487-0111 trials is Novo Nordisk A/S. Each trial row links to the full study detail page including sponsor information.
Sources and methodology
Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming NNC0487-0111as an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.
Last refreshed .
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