Masitinib Clinical Trials (2026): 36 Studies for Mastocytosis & Coronavirus Disease 2019

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

36 Masitinib clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 28 indications (including Mastocytosis & Coronavirus Disease 2019) and 9,008 total planned enrollment. 19 Phase 3 Masitinib trials and 13 Phase 2 are listed. 3 Masitinib clinical trials are actively recruiting at 6 U.S. sites across 6 states. Most recent activity: NCT05564169 (Dec 2029).

Where to Participate: All Masitinib Trial Sites in the U.S. (6 sites across 6 states)

Every actively recruiting Masitinibtrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
ALUniversity of Alabama at BirminghamBirmingham35294NCT03127267Map
CAUniversity of Southern CaliforniaLos Angeles90007NCT03127267Map
KYUniversity of KentuckyLexington40506NCT03127267Map
MDJohns Hopkins Medicine Brain Science InstituteBaltimore21205NCT03127267Map
MALahey Hospital and Medical CenterBurlington01805NCT03127267Map
VAUniversity of Virginia Health SystemCharlottesville22903NCT03127267Map

Masitinib clinical trials at a glance: phase × recruitment status

Phaserecruitingcompletedterminatedsuspendednot yet recruitingunknownTotal
P210313
P2/P3314
P319512119

Recruiting Masitinib clinical trials (3)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT05564169Masitinib in Patients With Mild Alzheimer's DiseaseP3Alzheimer Disease600Jun 2026
NCT07174492Efficacy and Safety of Masitinib in Combination With SoC Versus Placebo in the Treatment of ALS PatientsP3Amyotrophic Lateral Sclerosis (ALS)412Jan 2026
NCT03127267Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS PatientsP3Amyotrophic Lateral Sclerosis495Feb 2021

Masitinib clinical trials by indication

Alzheimer Disease (2)

NCTAcronymPhaseStatusTitle
NCT05564169P3not yet recruitingMasitinib in Patients With Mild Alzheimer's Disease
NCT01872598P3completedMasitinib in Patients With Mild to Moderate Alzheimer's Disease

Amyotrophic Lateral Sclerosis (ALS) (2)

NCTAcronymPhaseStatusTitle
NCT07174492P3not yet recruitingEfficacy and Safety of Masitinib in Combination With SoC Versus Placebo in the Treatment of ALS Patients
NCT02588677ALSP2/P3completedMasitinib in Combination With Riluzole for the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS)

Indolent Systemic Mastocytosis (2)

NCTAcronymPhaseStatusTitle
NCT04333108P3unknownMasitinib in Severe Indolent or Smoldering Systemic Mastocytosis Unresponsive to Optimal Symptomatic Treatment
NCT00814073AB06006P3completedMasitinib in Severe Indolent or Smoldering Systemic Mastocytosis

Asthma (2)

NCTAcronymPhaseStatusTitle
NCT03771040P3completedMasitinib in the Treatment of Patients With Severe Uncontrolled Asthma and Elevated Eosinophil Levels
NCT01449162P3completedMasitinib in Treatment of Patients With Severe Persistent Asthma Treated With Oral Corticosteroids

Gastrointestinal Stromal Tumors (2)

NCTAcronymPhaseStatusTitle
NCT01694277P3completedMasitinib in Patients With Gastrointestinal Stromal Tumour After Progression With Imatinib
NCT00812240GISTP3terminatedMasitinib in First Line Treatment of Gastro-Intestinal Stromal Tumor (GIST)

Multiple Myeloma (2)

NCTAcronymPhaseStatusTitle
NCT01470131P3terminatedA Phase 3 Study to Evaluate Efficacy and Safety of Masitinib in Patients With Relapse or Refractory Multiple Myeloma
NCT00866138P2completedMasitinib in Relapse or Refractory Multiple Myeloma With t(4/14) Translocation Expressing or Not FGFR3

Rheumatoid Arthritis (2)

NCTAcronymPhaseStatusTitle
NCT00913432P2completedMasitinib in Combination With Methotrexate, in Treatment of Patients With Active Rheumatoid Arthritis
NCT00831922P2completedEfficacy of Oral AB1010 in Adult Patients With Active Rheumatoid Arthritis

Mastocytosis (2)

NCTAcronymPhaseStatusTitle
NCT01266369P2completedMasitinib in Patients With Mastocytosis With Handicap and Bearing the D816V Mutation
NCT00831974P2completedEfficacy of AB1010 in Patients With Systemic Indolent Mastocytosis

Mast Cell Activation Syndrome (1)

NCTAcronymPhaseStatusTitle
NCT05449444P2unknownMasitinib for the Treatment of Severe Mast Cell Activation Syndrome

Progressive Multiple Sclerosis (1)

NCTAcronymPhaseStatusTitle
NCT05441488MAXIMSP3suspendedMasitinib in the Treatment of Patients With Primary Progressive or Non-active Secondary Progressive Multiple Sclerosis

Covid19 (1)

NCTAcronymPhaseStatusTitle
NCT05047783P2unknownMasitinib in Patients With Symptomatic Mild to Moderate COVID-19

Amyotrophic Lateral Sclerosis (1)

NCTAcronymPhaseStatusTitle
NCT03127267P3recruitingEfficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients

SARS-CoV 2 (1)

NCTAcronymPhaseStatusTitle
NCT04622865P2unknownMasitinib Combined With Isoquercetin and Best Supportive Care in Hospitalized Patients With Moderate and Severe COVID-19

Gastro-Intestinal Stromal Tumour (1)

NCTAcronymPhaseStatusTitle
NCT02009423P3terminatedMasitinib in Patients With Localized, Primary GIST After Complete Surgery and With High Risk of Recurrence

Colorectal Cancer Metastatic (1)

NCTAcronymPhaseStatusTitle
NCT03556956P2/P3completedMasitinib in Combination With FOLFIRI in Third or Fourth Line of Treatment of Patients With Metastatic Colorectal Cancer

Metastatic Castrate Resistant Prostate Cancer (1)

NCTAcronymPhaseStatusTitle
NCT03761225P3completedMasitinib Plus Docetaxel in Metastatic Castration-resistant Prostate Cancer

Locally Advanced or Metastatic Pancreatic Cancer (1)

NCTAcronymPhaseStatusTitle
NCT03766295P3completedMasitinib Plus Gemcitabine in Pancreatic Cancer

Ovarian Cancer (1)

NCTAcronymPhaseStatusTitle
NCT02490488P2/P3completedMasitinib in Combination With Gemcitabine in Advanced/Metastatic Epithelial Ovarian Cancer Patients

Metastatic Colorectal Cancer (1)

NCTAcronymPhaseStatusTitle
NCT02605044P3terminatedMasitinib in Combination With FOLFIRI for Second-line Treatment of Patients With Metastatic Colorectal Cancer

Multiple Sclerosis, Secondary Progressive (1)

NCTAcronymPhaseStatusTitle
NCT01433497P3completedEfficacy and Safety of Masitinib in the Treatment of Progressive Multiple Sclerosis

Rheumatoid Arthritis (RA) (1)

NCTAcronymPhaseStatusTitle
NCT01410695P2/P3terminatedMasitinib in Refractory Active Rheumatoid Arthritis

Metastatic Melanoma (1)

NCTAcronymPhaseStatusTitle
NCT01280565P3terminatedMasitinib in Non-Resectable or Metastatic Stage 3/4 Melanoma Carrying a Mutation in the Juxta Membrane Domain of c-Kit

Pancreatic Cancer (1)

NCTAcronymPhaseStatusTitle
NCT00789633P3completedMasitinib in Combination With Gemcitabine for Treatment of Patients With Advanced/Metastatic Pancreatic Cancer

Gastro Intestinal Stromal Tumor (1)

NCTAcronymPhaseStatusTitle
NCT01506336P2completedMasitinib in Patients With Gastro-Intestinal Stromal Tumour Resistant to Imatinib

Alzheimer's Disease (1)

NCTAcronymPhaseStatusTitle
NCT00976118AB1010P2completedActivity of Masitinib (AB1010) in Mild to Moderate Alzheimer's Disease

Psoriasis (1)

NCTAcronymPhaseStatusTitle
NCT01045577P2completedA Double-blind, Placebo-controlled, Randomized, Parallel-group Study to Evaluate the Activity of Oral AB1010 in Adults Patients With Moderate to Severe Chronic Plaque Psoriasis

Multiple Sclerosis (1)

NCTAcronymPhaseStatusTitle
NCT01450488P2completedMasitinib in Primary Progressive Multiple Sclerosis or Relapse-free Secondary Progressive Multiple Sclerosis

Gastro-intestinal Stromal Tumours (1)

NCTAcronymPhaseStatusTitle
NCT00998751GISTP2completedMasitinib in Locally Advanced/Metastatic Gastro-intestinal Stromal Tumour (GIST)

Masitinib pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
MAXIMSNCT05441488P3suspendedProgressive Multiple Sclerosis800
GISTNCT00812240P3terminatedGastrointestinal Stromal Tumors335
AB06006NCT00814073P3completedIndolent Systemic Mastocytosis135PMID 28069279
GISTNCT00998751P2completedGastro-intestinal Stromal Tumours30PMID 20211560
AB1010NCT00976118P2completedAlzheimer's Disease34PMID 21504563

Terminated and withdrawn Masitinib trials (7)

Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.

All Masitinib trials (36)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT05564169Masitinib in Patients With Mild Alzheimer's DiseaseP3not yet recruiting600AB ScienceJun 2026
NCT07174492Efficacy and Safety of Masitinib in Combination With SoC Versus Placebo in the Treatment of ALS PatientsP3not yet recruiting412AB ScienceJan 2026
NCT05441488MAXIMSMasitinib in the Treatment of Patients With Primary Progressive or Non-active Secondary Progressive Multiple SclerosisP3suspended800AB ScienceJun 2022
NCT03127267Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS PatientsP3recruiting495AB ScienceFeb 2021
NCT04333108Masitinib in Severe Indolent or Smoldering Systemic Mastocytosis Unresponsive to Optimal Symptomatic TreatmentP3unknown140AB ScienceJul 2020
NCT05449444Masitinib for the Treatment of Severe Mast Cell Activation SyndromeP2unknown72AB ScienceJul 2022
NCT05047783Masitinib in Patients With Symptomatic Mild to Moderate COVID-19P2unknown78AB ScienceNov 2021
NCT04622865Masitinib Combined With Isoquercetin and Best Supportive Care in Hospitalized Patients With Moderate and Severe COVID-19P2unknown200AB ScienceJun 2020
NCT03556956Masitinib in Combination With FOLFIRI in Third or Fourth Line of Treatment of Patients With Metastatic Colorectal CancerP2/P3completed219AB ScienceJul 2015
NCT03766295Masitinib Plus Gemcitabine in Pancreatic CancerP3completed377AB ScienceJul 2014
NCT02490488Masitinib in Combination With Gemcitabine in Advanced/Metastatic Epithelial Ovarian Cancer PatientsP2/P3completed248AB ScienceApr 2014
NCT01694277Masitinib in Patients With Gastrointestinal Stromal Tumour After Progression With ImatinibP3completed258AB ScienceApr 2012
NCT01872598Masitinib in Patients With Mild to Moderate Alzheimer's DiseaseP3completed721AB ScienceJan 2012
NCT03761225Masitinib Plus Docetaxel in Metastatic Castration-resistant Prostate CancerP3completed714AB ScienceSep 2014
NCT03771040Masitinib in the Treatment of Patients With Severe Uncontrolled Asthma and Elevated Eosinophil LevelsP3completed347AB ScienceDec 2016
NCT01433497Efficacy and Safety of Masitinib in the Treatment of Progressive Multiple SclerosisP3completed656AB ScienceAug 2011
NCT01449162Masitinib in Treatment of Patients With Severe Persistent Asthma Treated With Oral CorticosteroidsP3completed420AB ScienceJan 2011
NCT01280565Masitinib in Non-Resectable or Metastatic Stage 3/4 Melanoma Carrying a Mutation in the Juxta Membrane Domain of c-KitP3terminated134AB ScienceJan 2011
NCT00812240GISTMasitinib in First Line Treatment of Gastro-Intestinal Stromal Tumor (GIST)P3terminated335AB ScienceJan 2009
NCT02588677ALSMasitinib in Combination With Riluzole for the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS)P2/P3completed394AB ScienceApr 2013
NCT02605044Masitinib in Combination With FOLFIRI for Second-line Treatment of Patients With Metastatic Colorectal CancerP3terminated123AB ScienceJan 2014
NCT01470131A Phase 3 Study to Evaluate Efficacy and Safety of Masitinib in Patients With Relapse or Refractory Multiple MyelomaP3terminated147AB ScienceMay 2011
NCT02009423Masitinib in Patients With Localized, Primary GIST After Complete Surgery and With High Risk of RecurrenceP3terminated7AB ScienceJul 2015
NCT00814073AB06006Masitinib in Severe Indolent or Smoldering Systemic MastocytosisP3completed135AB ScienceDec 2008
NCT01410695Masitinib in Refractory Active Rheumatoid ArthritisP2/P3terminated324AB ScienceJul 2011
NCT00998751GISTMasitinib in Locally Advanced/Metastatic Gastro-intestinal Stromal Tumour (GIST)P2completed30AB ScienceJun 2005
NCT00789633Masitinib in Combination With Gemcitabine for Treatment of Patients With Advanced/Metastatic Pancreatic CancerP3completed353AB ScienceNov 2008
NCT01506336Masitinib in Patients With Gastro-Intestinal Stromal Tumour Resistant to ImatinibP2completed44AB ScienceOct 2008
NCT00866138Masitinib in Relapse or Refractory Multiple Myeloma With t(4/14) Translocation Expressing or Not FGFR3P2completed24AB ScienceFeb 2005
NCT00913432Masitinib in Combination With Methotrexate, in Treatment of Patients With Active Rheumatoid ArthritisP2completed20AB ScienceMar 2007
NCT01266369Masitinib in Patients With Mastocytosis With Handicap and Bearing the D816V MutationP2completed21AB ScienceFeb 2007
NCT01450488Masitinib in Primary Progressive Multiple Sclerosis or Relapse-free Secondary Progressive Multiple SclerosisP2completed35AB ScienceJun 2005
NCT00976118AB1010Activity of Masitinib (AB1010) in Mild to Moderate Alzheimer's DiseaseP2completed34AB ScienceFeb 2006
NCT01045577A Double-blind, Placebo-controlled, Randomized, Parallel-group Study to Evaluate the Activity of Oral AB1010 in Adults Patients With Moderate to Severe Chronic Plaque PsoriasisP2completed25AB ScienceSep 2005
NCT00831974Efficacy of AB1010 in Patients With Systemic Indolent MastocytosisP2completed23AB ScienceOct 2004
NCT00831922Efficacy of Oral AB1010 in Adult Patients With Active Rheumatoid ArthritisP2completed43AB ScienceSep 2004

Masitinib clinical trials: frequently asked questions

How many Masitinib clinical trials are there?
36 Masitinib clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 1 is actively recruiting participants. 22 are marked completed.
Are Masitinib clinical trials recruiting in 2026?
Yes — 1 Masitinib trial is actively recruiting in 2026, with 6 U.S. sites across 6 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Masitinib being studied for?
Masitinib is being studied for Mastocytosis, Coronavirus Disease 2019, Amyotrophic Lateral Sclerosis (ALS), Gastrointestinal Stromal Tumors, Multiple Myeloma and 28 more. The trials are grouped by indication on this page.
What phase is Masitinib in?
Masitinib clinical trials span 19 Phase 3, 13 Phase 2. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Masitinib clinical trials?
The lead sponsor across the most Masitinib trials is AB Science. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Masitinibas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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