Masitinib Clinical Trials (2026): 36 Studies for Mastocytosis & Coronavirus Disease 2019
Hipa.ai Research · Source: ClinicalTrials.gov / AACT
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36 Masitinib clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 28 indications (including Mastocytosis & Coronavirus Disease 2019) and 9,008 total planned enrollment. 19 Phase 3 Masitinib trials and 13 Phase 2 are listed. 3 Masitinib clinical trials are actively recruiting at 6 U.S. sites across 6 states. Most recent activity: NCT05564169 (Dec 2029).
Where to Participate: All Masitinib Trial Sites in the U.S. (6 sites across 6 states)
Every actively recruiting Masitinibtrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.
| State | Facility | City | Trial | Map |
|---|---|---|---|---|
| AL | University of Alabama at Birmingham | Birmingham35294 | NCT03127267 | Map |
| CA | University of Southern California | Los Angeles90007 | NCT03127267 | Map |
| KY | University of Kentucky | Lexington40506 | NCT03127267 | Map |
| MD | Johns Hopkins Medicine Brain Science Institute | Baltimore21205 | NCT03127267 | Map |
| MA | Lahey Hospital and Medical Center | Burlington01805 | NCT03127267 | Map |
| VA | University of Virginia Health System | Charlottesville22903 | NCT03127267 | Map |
Masitinib clinical trials at a glance: phase × recruitment status
| Phase | recruiting | completed | terminated | suspended | not yet recruiting | unknown | Total |
|---|---|---|---|---|---|---|---|
| P2 | 10 | 3 | 13 | ||||
| P2/P3 | 3 | 1 | 4 | ||||
| P3 | 1 | 9 | 5 | 1 | 2 | 1 | 19 |
Recruiting Masitinib clinical trials (3)
Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).
| NCT ID | Title | Phase | Indication | Enrollment | Started |
|---|---|---|---|---|---|
| NCT05564169 | Masitinib in Patients With Mild Alzheimer's Disease | P3 | Alzheimer Disease | 600 | Jun 2026 |
| NCT07174492 | Efficacy and Safety of Masitinib in Combination With SoC Versus Placebo in the Treatment of ALS Patients | P3 | Amyotrophic Lateral Sclerosis (ALS) | 412 | Jan 2026 |
| NCT03127267 | Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients | P3 | Amyotrophic Lateral Sclerosis | 495 | Feb 2021 |
Masitinib clinical trials by indication
Alzheimer Disease (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05564169 | — | P3 | not yet recruiting | Masitinib in Patients With Mild Alzheimer's Disease |
| NCT01872598 | — | P3 | completed | Masitinib in Patients With Mild to Moderate Alzheimer's Disease |
Amyotrophic Lateral Sclerosis (ALS) (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07174492 | — | P3 | not yet recruiting | Efficacy and Safety of Masitinib in Combination With SoC Versus Placebo in the Treatment of ALS Patients |
| NCT02588677 | ALS | P2/P3 | completed | Masitinib in Combination With Riluzole for the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS) |
Indolent Systemic Mastocytosis (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT04333108 | — | P3 | unknown | Masitinib in Severe Indolent or Smoldering Systemic Mastocytosis Unresponsive to Optimal Symptomatic Treatment |
| NCT00814073 | AB06006 | P3 | completed | Masitinib in Severe Indolent or Smoldering Systemic Mastocytosis |
Asthma (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT03771040 | — | P3 | completed | Masitinib in the Treatment of Patients With Severe Uncontrolled Asthma and Elevated Eosinophil Levels |
| NCT01449162 | — | P3 | completed | Masitinib in Treatment of Patients With Severe Persistent Asthma Treated With Oral Corticosteroids |
Gastrointestinal Stromal Tumors (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT01694277 | — | P3 | completed | Masitinib in Patients With Gastrointestinal Stromal Tumour After Progression With Imatinib |
| NCT00812240 | GIST | P3 | terminated | Masitinib in First Line Treatment of Gastro-Intestinal Stromal Tumor (GIST) |
Multiple Myeloma (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT01470131 | — | P3 | terminated | A Phase 3 Study to Evaluate Efficacy and Safety of Masitinib in Patients With Relapse or Refractory Multiple Myeloma |
| NCT00866138 | — | P2 | completed | Masitinib in Relapse or Refractory Multiple Myeloma With t(4/14) Translocation Expressing or Not FGFR3 |
Rheumatoid Arthritis (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT00913432 | — | P2 | completed | Masitinib in Combination With Methotrexate, in Treatment of Patients With Active Rheumatoid Arthritis |
| NCT00831922 | — | P2 | completed | Efficacy of Oral AB1010 in Adult Patients With Active Rheumatoid Arthritis |
Mastocytosis (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT01266369 | — | P2 | completed | Masitinib in Patients With Mastocytosis With Handicap and Bearing the D816V Mutation |
| NCT00831974 | — | P2 | completed | Efficacy of AB1010 in Patients With Systemic Indolent Mastocytosis |
Mast Cell Activation Syndrome (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05449444 | — | P2 | unknown | Masitinib for the Treatment of Severe Mast Cell Activation Syndrome |
Progressive Multiple Sclerosis (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05441488 | MAXIMS | P3 | suspended | Masitinib in the Treatment of Patients With Primary Progressive or Non-active Secondary Progressive Multiple Sclerosis |
Covid19 (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05047783 | — | P2 | unknown | Masitinib in Patients With Symptomatic Mild to Moderate COVID-19 |
Amyotrophic Lateral Sclerosis (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT03127267 | — | P3 | recruiting | Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients |
SARS-CoV 2 (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT04622865 | — | P2 | unknown | Masitinib Combined With Isoquercetin and Best Supportive Care in Hospitalized Patients With Moderate and Severe COVID-19 |
Gastro-Intestinal Stromal Tumour (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT02009423 | — | P3 | terminated | Masitinib in Patients With Localized, Primary GIST After Complete Surgery and With High Risk of Recurrence |
Colorectal Cancer Metastatic (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT03556956 | — | P2/P3 | completed | Masitinib in Combination With FOLFIRI in Third or Fourth Line of Treatment of Patients With Metastatic Colorectal Cancer |
Metastatic Castrate Resistant Prostate Cancer (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT03761225 | — | P3 | completed | Masitinib Plus Docetaxel in Metastatic Castration-resistant Prostate Cancer |
Locally Advanced or Metastatic Pancreatic Cancer (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT03766295 | — | P3 | completed | Masitinib Plus Gemcitabine in Pancreatic Cancer |
Ovarian Cancer (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT02490488 | — | P2/P3 | completed | Masitinib in Combination With Gemcitabine in Advanced/Metastatic Epithelial Ovarian Cancer Patients |
Metastatic Colorectal Cancer (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT02605044 | — | P3 | terminated | Masitinib in Combination With FOLFIRI for Second-line Treatment of Patients With Metastatic Colorectal Cancer |
Multiple Sclerosis, Secondary Progressive (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT01433497 | — | P3 | completed | Efficacy and Safety of Masitinib in the Treatment of Progressive Multiple Sclerosis |
Rheumatoid Arthritis (RA) (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT01410695 | — | P2/P3 | terminated | Masitinib in Refractory Active Rheumatoid Arthritis |
Metastatic Melanoma (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT01280565 | — | P3 | terminated | Masitinib in Non-Resectable or Metastatic Stage 3/4 Melanoma Carrying a Mutation in the Juxta Membrane Domain of c-Kit |
Pancreatic Cancer (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT00789633 | — | P3 | completed | Masitinib in Combination With Gemcitabine for Treatment of Patients With Advanced/Metastatic Pancreatic Cancer |
Gastro Intestinal Stromal Tumor (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT01506336 | — | P2 | completed | Masitinib in Patients With Gastro-Intestinal Stromal Tumour Resistant to Imatinib |
Alzheimer's Disease (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT00976118 | AB1010 | P2 | completed | Activity of Masitinib (AB1010) in Mild to Moderate Alzheimer's Disease |
Psoriasis (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT01045577 | — | P2 | completed | A Double-blind, Placebo-controlled, Randomized, Parallel-group Study to Evaluate the Activity of Oral AB1010 in Adults Patients With Moderate to Severe Chronic Plaque Psoriasis |
Multiple Sclerosis (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT01450488 | — | P2 | completed | Masitinib in Primary Progressive Multiple Sclerosis or Relapse-free Secondary Progressive Multiple Sclerosis |
Gastro-intestinal Stromal Tumours (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT00998751 | GIST | P2 | completed | Masitinib in Locally Advanced/Metastatic Gastro-intestinal Stromal Tumour (GIST) |
Masitinib pivotal trial highlights (Phase 2/3/4)
Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.
| Acronym | NCT | Phase | Status | Indication | Enrollment | PubMed |
|---|---|---|---|---|---|---|
| MAXIMS | NCT05441488 | P3 | suspended | Progressive Multiple Sclerosis | 800 | — |
| GIST | NCT00812240 | P3 | terminated | Gastrointestinal Stromal Tumors | 335 | — |
| AB06006 | NCT00814073 | P3 | completed | Indolent Systemic Mastocytosis | 135 | PMID 28069279 |
| GIST | NCT00998751 | P2 | completed | Gastro-intestinal Stromal Tumours | 30 | PMID 20211560 |
| AB1010 | NCT00976118 | P2 | completed | Alzheimer's Disease | 34 | PMID 21504563 |
Terminated and withdrawn Masitinib trials (7)
Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.
- NCT05441488suspendedMasitinib in the Treatment of Patients With Primary Progressive or Non-active Secondary Progressive Multiple Sclerosis
- NCT01280565terminatedMasitinib in Non-Resectable or Metastatic Stage 3/4 Melanoma Carrying a Mutation in the Juxta Membrane Domain of c-Kit
- NCT00812240terminatedMasitinib in First Line Treatment of Gastro-Intestinal Stromal Tumor (GIST)
- NCT02605044terminatedMasitinib in Combination With FOLFIRI for Second-line Treatment of Patients With Metastatic Colorectal Cancer
- NCT01470131terminatedA Phase 3 Study to Evaluate Efficacy and Safety of Masitinib in Patients With Relapse or Refractory Multiple Myeloma
- NCT02009423terminatedMasitinib in Patients With Localized, Primary GIST After Complete Surgery and With High Risk of Recurrence
- NCT01410695terminatedMasitinib in Refractory Active Rheumatoid Arthritis
All Masitinib trials (36)
Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.
| NCT ID | Acronym | Title | Phase | Status | Enrollment | Sponsor | Started |
|---|---|---|---|---|---|---|---|
| NCT05564169 | Masitinib in Patients With Mild Alzheimer's Disease | P3 | not yet recruiting | 600 | AB Science | Jun 2026 | |
| NCT07174492 | Efficacy and Safety of Masitinib in Combination With SoC Versus Placebo in the Treatment of ALS Patients | P3 | not yet recruiting | 412 | AB Science | Jan 2026 | |
| NCT05441488 | MAXIMS | Masitinib in the Treatment of Patients With Primary Progressive or Non-active Secondary Progressive Multiple Sclerosis | P3 | suspended | 800 | AB Science | Jun 2022 |
| NCT03127267 | Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients | P3 | recruiting | 495 | AB Science | Feb 2021 | |
| NCT04333108 | Masitinib in Severe Indolent or Smoldering Systemic Mastocytosis Unresponsive to Optimal Symptomatic Treatment | P3 | unknown | 140 | AB Science | Jul 2020 | |
| NCT05449444 | Masitinib for the Treatment of Severe Mast Cell Activation Syndrome | P2 | unknown | 72 | AB Science | Jul 2022 | |
| NCT05047783 | Masitinib in Patients With Symptomatic Mild to Moderate COVID-19 | P2 | unknown | 78 | AB Science | Nov 2021 | |
| NCT04622865 | Masitinib Combined With Isoquercetin and Best Supportive Care in Hospitalized Patients With Moderate and Severe COVID-19 | P2 | unknown | 200 | AB Science | Jun 2020 | |
| NCT03556956 | Masitinib in Combination With FOLFIRI in Third or Fourth Line of Treatment of Patients With Metastatic Colorectal Cancer | P2/P3 | completed | 219 | AB Science | Jul 2015 | |
| NCT03766295 | Masitinib Plus Gemcitabine in Pancreatic Cancer | P3 | completed | 377 | AB Science | Jul 2014 | |
| NCT02490488 | Masitinib in Combination With Gemcitabine in Advanced/Metastatic Epithelial Ovarian Cancer Patients | P2/P3 | completed | 248 | AB Science | Apr 2014 | |
| NCT01694277 | Masitinib in Patients With Gastrointestinal Stromal Tumour After Progression With Imatinib | P3 | completed | 258 | AB Science | Apr 2012 | |
| NCT01872598 | Masitinib in Patients With Mild to Moderate Alzheimer's Disease | P3 | completed | 721 | AB Science | Jan 2012 | |
| NCT03761225 | Masitinib Plus Docetaxel in Metastatic Castration-resistant Prostate Cancer | P3 | completed | 714 | AB Science | Sep 2014 | |
| NCT03771040 | Masitinib in the Treatment of Patients With Severe Uncontrolled Asthma and Elevated Eosinophil Levels | P3 | completed | 347 | AB Science | Dec 2016 | |
| NCT01433497 | Efficacy and Safety of Masitinib in the Treatment of Progressive Multiple Sclerosis | P3 | completed | 656 | AB Science | Aug 2011 | |
| NCT01449162 | Masitinib in Treatment of Patients With Severe Persistent Asthma Treated With Oral Corticosteroids | P3 | completed | 420 | AB Science | Jan 2011 | |
| NCT01280565 | Masitinib in Non-Resectable or Metastatic Stage 3/4 Melanoma Carrying a Mutation in the Juxta Membrane Domain of c-Kit | P3 | terminated | 134 | AB Science | Jan 2011 | |
| NCT00812240 | GIST | Masitinib in First Line Treatment of Gastro-Intestinal Stromal Tumor (GIST) | P3 | terminated | 335 | AB Science | Jan 2009 |
| NCT02588677 | ALS | Masitinib in Combination With Riluzole for the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS) | P2/P3 | completed | 394 | AB Science | Apr 2013 |
| NCT02605044 | Masitinib in Combination With FOLFIRI for Second-line Treatment of Patients With Metastatic Colorectal Cancer | P3 | terminated | 123 | AB Science | Jan 2014 | |
| NCT01470131 | A Phase 3 Study to Evaluate Efficacy and Safety of Masitinib in Patients With Relapse or Refractory Multiple Myeloma | P3 | terminated | 147 | AB Science | May 2011 | |
| NCT02009423 | Masitinib in Patients With Localized, Primary GIST After Complete Surgery and With High Risk of Recurrence | P3 | terminated | 7 | AB Science | Jul 2015 | |
| NCT00814073 | AB06006 | Masitinib in Severe Indolent or Smoldering Systemic Mastocytosis | P3 | completed | 135 | AB Science | Dec 2008 |
| NCT01410695 | Masitinib in Refractory Active Rheumatoid Arthritis | P2/P3 | terminated | 324 | AB Science | Jul 2011 | |
| NCT00998751 | GIST | Masitinib in Locally Advanced/Metastatic Gastro-intestinal Stromal Tumour (GIST) | P2 | completed | 30 | AB Science | Jun 2005 |
| NCT00789633 | Masitinib in Combination With Gemcitabine for Treatment of Patients With Advanced/Metastatic Pancreatic Cancer | P3 | completed | 353 | AB Science | Nov 2008 | |
| NCT01506336 | Masitinib in Patients With Gastro-Intestinal Stromal Tumour Resistant to Imatinib | P2 | completed | 44 | AB Science | Oct 2008 | |
| NCT00866138 | Masitinib in Relapse or Refractory Multiple Myeloma With t(4/14) Translocation Expressing or Not FGFR3 | P2 | completed | 24 | AB Science | Feb 2005 | |
| NCT00913432 | Masitinib in Combination With Methotrexate, in Treatment of Patients With Active Rheumatoid Arthritis | P2 | completed | 20 | AB Science | Mar 2007 | |
| NCT01266369 | Masitinib in Patients With Mastocytosis With Handicap and Bearing the D816V Mutation | P2 | completed | 21 | AB Science | Feb 2007 | |
| NCT01450488 | Masitinib in Primary Progressive Multiple Sclerosis or Relapse-free Secondary Progressive Multiple Sclerosis | P2 | completed | 35 | AB Science | Jun 2005 | |
| NCT00976118 | AB1010 | Activity of Masitinib (AB1010) in Mild to Moderate Alzheimer's Disease | P2 | completed | 34 | AB Science | Feb 2006 |
| NCT01045577 | A Double-blind, Placebo-controlled, Randomized, Parallel-group Study to Evaluate the Activity of Oral AB1010 in Adults Patients With Moderate to Severe Chronic Plaque Psoriasis | P2 | completed | 25 | AB Science | Sep 2005 | |
| NCT00831974 | Efficacy of AB1010 in Patients With Systemic Indolent Mastocytosis | P2 | completed | 23 | AB Science | Oct 2004 | |
| NCT00831922 | Efficacy of Oral AB1010 in Adult Patients With Active Rheumatoid Arthritis | P2 | completed | 43 | AB Science | Sep 2004 |
Masitinib clinical trials: frequently asked questions
- How many Masitinib clinical trials are there?
- 36 Masitinib clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 1 is actively recruiting participants. 22 are marked completed.
- Are Masitinib clinical trials recruiting in 2026?
- Yes — 1 Masitinib trial is actively recruiting in 2026, with 6 U.S. sites across 6 states. See the recruiting trials and the per-state site list further down this page.
- What conditions is Masitinib being studied for?
- Masitinib is being studied for Mastocytosis, Coronavirus Disease 2019, Amyotrophic Lateral Sclerosis (ALS), Gastrointestinal Stromal Tumors, Multiple Myeloma and 28 more. The trials are grouped by indication on this page.
- What phase is Masitinib in?
- Masitinib clinical trials span 19 Phase 3, 13 Phase 2. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
- Who sponsors Masitinib clinical trials?
- The lead sponsor across the most Masitinib trials is AB Science. Each trial row links to the full study detail page including sponsor information.
Sources and methodology
Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Masitinibas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.
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