Masitinib in Combination With Gemcitabine in Advanced/Metastatic Epithelial Ovarian Cancer Patients
- Sponsor
- AB Science
- Study ID
- NCT02490488
- Phase
- PHASE2/PHASE3
- Status
- Completed
Conditions
Eligibility Criteria
- Sex
- FEMALE
- Age
- 18 Years - N/A
- Healthy Volunteers
- Not accepted
Interventions
- Masitinib — DRUG
- Gemcitabine — DRUG
- Placebo — DRUG
Study Details
The objective is to evaluate the efficacy and safety of masitinib in combination with gemcitabine in refractory ovarian cancer patients.
Key Dates
- Start date
- Apr 30, 2014
- Status verified
- Apr 2020
- Primary completion
- Dec 31, 2020
- Completion
- Dec 31, 2020
Study Design
- Enrollment
- 248 participants (actual)
- Allocation
- RANDOMIZED
- Intervention model
- PARALLEL
- Primary purpose
- TREATMENT
Arms
- Experimental: Masitinib & gemcitabineParticipants receive masitinib (6 mg/kg/day), given orally twice daily, plus gemcitabine 1000 mg/m² administered by 30 minutes infusion once a week during 3 weeks followed by 1 week without infusion.
- Placebo Comparator: Placebo & gemcitabineParticipants receive placebo (6 mg/kg/day), given orally twice daily, plus gemcitabine 1000 mg/m² administered by 30 minutes infusion once a week during 3 weeks followed by 1 week without infusion.
Primary Outcome Measure
Overall survival (OS) [ Time Frame: From day of randomization to death, assessed for a maximum of 60 months ]
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