Masitinib in Combination With Riluzole for the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS)
- Sponsor
- AB Science
- Study ID
- NCT02588677
- Phase
- PHASE2/PHASE3
- Status
- Completed
Conditions
- Amyotrophic Lateral Sclerosis (ALS)
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - 75 Years
- Healthy Volunteers
- Not accepted
Interventions
- Masitinib (4.5) — DRUG4.5 mg/kg/day
- Riluzole — DRUG
- Placebo — DRUG
- Masitinib (3.0) — DRUG3 mg/kg/day
Study Details
The objective is to compare the efficacy and safety of masitinib in combination with riluzole in the treatment of patients suffering from Amyotrophic Lateral Sclerosis (ALS).
Key Dates
- Start date
- Apr 30, 2013
- Status verified
- Sep 2023
- Primary completion
- Dec 5, 2016
- Completion
- Mar 31, 2018
Study Design
- Enrollment
- 394 participants (actual)
- Allocation
- RANDOMIZED
- Intervention model
- PARALLEL
- Primary purpose
- TREATMENT
Arms
- Experimental: Masitinib (3.0) & Riluzolemasitinib 3 mg/kg/day + riluzole
- Experimental: Masitinib (4.5) & Riluzolemasitinib 4.5 mg/kg/day (2) + riluzole
- Placebo Comparator: Placebo & RiluzoleMatched placebo
Primary Outcome Measure
Change in Amyotrophic Lateral Sclerosis functional rating scale (ALSFRS)-Revised [ Time Frame: From baseline to week 48 ]
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