Adagrasib Clinical Trials (2026): 26 Studies for Metastatic Cancer & Advanced Cancer

Where to Participate: All Adagrasib Trial Sites in the U.S. (150 sites across 34 states)

Every actively recruiting Adagrasibtrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

Adagrasib clinical trials at a glance: phase × recruitment status

Recruiting Adagrasib clinical trials (11)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

Adagrasib clinical trials by indication

Adagrasib pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

Terminated and withdrawn Adagrasib trials (7)

Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.

• NCT06130254terminatedPhase Ib Trial of the KRAS G12C Inhibitor Adagrasib (MRTX849) in Combination With the PARP Inhibitor Olaparib in Patients With KRAS G12C Mutated Advanced Solid Tumors, With a Focus on Gynecological, Breast, Pancreatic and KEAP1 Mutated Non-small Cell Lung Cancers
• NCT05472623withdrawnNeoadjuvant KRAS G12C Directed Therapy With Adagrasib (MRTX849) With or Without Nivolumab
• NCT06039384terminatedA Study of INCB099280 in Combination With Adagrasib in Adults With Advanced Solid Tumors Harboring a KRASG12C Mutation
• NCT05840510terminatedAdagrasib in Combination With Nab-Sirolimus in Patients With Advanced Solid Tumors and Non-Small Cell Lung Cancer With a KRAS G12C Mutation (KRYSTAL -19)
• NCT06024174terminatedA Study of BMS-986466 With Adagrasib With or Without Cetuximab in Participants With Kirsten Rat Sarcoma Virus Glycine 12 to Cysteine (KRAS G12C)-Mutant Solid Tumors
• NCT04418661terminatedSafety and Efficacy Study of Vociprotafib (SAR442720) in Combination With Other Agents in Advanced Malignancies
• NCT05848843withdrawnA Phase I Study of Adagrasib and Durvalumab for Treatment of Advanced Non-small Cell Lung Cancers and Gastro-intestinal Cancers Harboring KRAS G12C Mutations

All Adagrasib trials (26)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

Adagrasib clinical trials: frequently asked questions

How many Adagrasib clinical trials are there?

26 Adagrasib clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 9 are actively recruiting participants. 2 are marked completed.

Are Adagrasib clinical trials recruiting in 2026?

Yes — 9 Adagrasib trials are actively recruiting in 2026, with 150 U.S. sites across 34 states. See the recruiting trials and the per-state site list further down this page.

What conditions is Adagrasib being studied for?

Adagrasib is being studied for Metastatic Cancer, Advanced Cancer, NSCLC, Advanced Solid Tumors, Non Small Cell Lung Cancer and 46 more. The trials are grouped by indication on this page.

What phase is Adagrasib in?

Adagrasib clinical trials span 2 Phase 3, 8 Phase 2, 9 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.

Who sponsors Adagrasib clinical trials?

The lead sponsor across the most Adagrasib trials is Mirati Therapeutics Inc., with 12 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Adagrasibas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

Last refreshed June 18, 2026.