ASCEND-CRC: Profiling and Targeting Dynamic Tumor Resistance in Patients With Metastatic Colorectal Cancer

Part of paid clinical trials in Houston, Texas.

Sponsor
M.D. Anderson Cancer Center
Study ID
NCT07318389
Phase
EARLY_PHASE1
Status
Not Yet Recruiting

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Conditions

  • Dynamic Tumor Resistance
  • Metastatic Colorectal Cancer

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • SOC (Standard of care) — OTHER
    Blood draws, biopsies, samples and MRI.
  • Bevacizumab — DRUG
    Given by IV
  • Cetuximab — DRUG
    Given by Iv
  • Panitumumab — DRUG
    Given by Iv
  • FOLFIRI — DRUG
    Given by Iv
  • FOLFOX — DRUG
    Given by Iv
  • Encorafenib — DRUG
    Given by po
  • Adagrasib — DRUG
    Given by Po
  • Trifluridine/tipiracil (TAS-102) — DRUG
    Given by po
  • Trastuzumab deruxtecan — DRUG
    Given by IV
  • Tucatinib — DRUG
    Given by po
  • Sotorasib — DRUG
    Given by po

Study Details

To find out if certain drug/therapy combinations that are targeted to individual patients based on characteristics of their disease types may help to control the disease.

Key Dates

Start date
Jun 10, 2026
Status verified
Jun 2026
Primary completion
Nov 14, 2027
Completion
Nov 14, 2029

Study Design

Enrollment
100 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: ASCEND-CRC Sample Collection
    Standard of care

Primary Outcome Measure

safety and adverse events (AEs) [ Time Frame: Through study completion; an average of 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
MD Anderson Cancer CenterHoustonTexas77030
Kopetz Scott, MD
[email protected]
713-792-2828
Scott Kopetz, MD (PRINCIPAL_INVESTIGATOR)

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By research site
MD Anderson Cancer Center· Houston, TX

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