Trial results for a study evaluating a web-browser-based visual field test for Glaucoma were posted on ClinicalTrials.gov on 2026-05-18, showing patients completed an average of 94.32% of scheduled tests.
Background
Glaucoma is a group of eye conditions that damage the optic nerve, often due to abnormally high pressure in the eye. It is a leading cause of irreversible blindness worldwide. Regular monitoring of visual fields is crucial for detecting progression and guiding treatment decisions. Traditionally, visual field tests are conducted in an ophthalmologist's office, which can be inconvenient and burdensome for patients, potentially affecting adherence to recommended monitoring schedules. The development of accessible, at-home testing solutions, such as web-based visual field tests, aims to improve patient convenience and compliance with long-term monitoring requirements.
Trial design
This terminated study enrolled 8 participants with Glaucoma to assess patient persistence and adherence with a 6-month period of at-home visual field testing. The trial utilized a novel web-based visual field test, EyeSimplify (M&S Technologies, Niles, IL). The main questions the trial aimed to answer were how adherent patients are to biweekly testing at home for 6 months, how patients perceive the ease of user experience, and whether the EyeSimplify platform could detect worsening of glaucoma-related visual field performance that could be corroborated by standard office-based care. The study was conducted as a single-arm trial with no specified phase.
Key results
The trial results provided several key measurements related to patient adherence, persistence, and visual field performance metrics:
- EyeSimplify Self-Test Adherence: The mean adherence was 94.32 percentage of tests completed, with a Standard Deviation of 13.38.
- EyeSimplify Self-Test Persistence: The mean persistence was 4.00 Consecutive Tests, with a Standard Deviation of 3.43.
- Visual Field Reliability Metric #1 - False Positive Rate: The mean false positive rate was 8.64 Percentage of FPs, with a Standard Deviation of 12.00.
- Visual Field Performance Metric #1 - Mean Deviation: The mean deviation was -12.50 dB, with a Standard Deviation of 8.24.
- Visual Field Performance Metric #2 - Pattern Standard Deviation: The mean pattern standard deviation was 7.36 dB, with a Standard Deviation of 1.94.
- Visual Field Performance Metric #4 - Foveal Threshold: The mean foveal threshold was 18.42 dB, with a Standard Deviation of 8.65.
What this means
The posted results suggest that a web-browser-based visual field test, EyeSimplify, achieved high patient adherence for at-home monitoring in individuals with glaucoma, with patients completing an average of 94.32% of their scheduled tests. This high adherence rate indicates the potential feasibility and patient acceptance of such a remote monitoring solution. The mean persistence of 4.00 consecutive tests, alongside the adherence data, supports the idea that patients are willing and able to consistently engage with the at-home testing platform. The visual field performance metrics, including mean deviation and pattern standard deviation, provide initial data points on the test's ability to capture relevant clinical information, although further comparative studies would be needed to fully assess its diagnostic accuracy against standard office-based tests. These findings imply that web-based visual field tests could offer a convenient and patient-friendly option for regular glaucoma monitoring, potentially improving long-term compliance and facilitating earlier detection of disease progression.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT05690152, titled "Persistence of Glaucoma Patients With Web-Browser-Based Visual Field Test", were posted on 2026-05-18 on clinicaltrials.gov.