Trial results for PeLear CCC, a study focused on Colorectal Cancer education, were posted on ClinicalTrials.gov on 2026-01-14. The study, which enrolled 60 Spanish-speaking Latino individuals, demonstrated that educational videos significantly improved participants' knowledge of colorectal cancer symptoms and their attitudes toward clinical trial participation.
Background
Colorectal cancer (CRC) remains a significant public health concern, and early detection and access to advanced treatments through clinical trials are crucial for improving patient outcomes. However, disparities in health literacy and access to information can hinder participation in screening programs and clinical research, particularly within specific ethnic and linguistic communities. For Latino populations, culturally and linguistically appropriate educational interventions are vital to address knowledge gaps and foster trust in the healthcare system, ultimately promoting engagement with cancer prevention and treatment initiatives.
Trial design
This completed study, identified as Phase NA, enrolled 60 Spanish-speaking individuals who identified as Latinos. The trial focused on conditions including Colorectal Cancer, Rectal Cancer, Colon Cancer, Colon Rectal Cancer, and Rectal Neoplasms. Participants attended an educational session where their baseline knowledge of CRC and willingness to participate in cancer clinical trials (CCT) were assessed. Following this, participants watched three educational videos on CRC in Spanish, after which their knowledge and willingness were re-evaluated. The study did not list specific primary outcomes but aimed to assess the impact of these educational videos.
Key results
The trial results indicated significant improvements in knowledge and attitudes following the educational intervention:
- For "Attitudes Regarding Participation in Clinical Trials-Conceptual Themes (General Clinical Trials)", positive attitudes were reported by 85 percentage of participants and 80 percentage of participants in distinct measurements.
- For "Attitudes Regarding Participation in Cancer Clinical Trials-Conceptual Themes (Cancer Clinical Trials)", positive attitudes were reported by 60 percentage of participants and 45 percentage of participants in distinct measurements.
- "Perceptions of Latino Community for Increasing Enrollment in Randomized Clinical Trials-Conceptual Themes (General Clinical Trials)" were positive for 90 percentage of participants and 80 percentage of participants in distinct measurements.
- "Holistic Themes" showed varied positive responses, including 58 percentage of participants, 100 percentage of participants, and 45 percentage of participants in distinct measurements.
- Regarding "Association of Educational Videos on Knowledge of Colorectal Cancer Symptoms", the mean score increased from 4.10 (Standard Error: 0.36) at baseline to 7.23 (Standard Error: 0.32) immediately post-video, and was measured at 6.95 (Standard Error: 0.29) on Study Day 2 (30 +/- 7 days).
Statistical analyses using ANOVA showed a highly significant difference (p-value: 0.0001) for "Post-video vs. Baseline" and "Study Day 2: 30 +/- 7 days vs. Baseline" comparisons across multiple outcomes, including knowledge of CRC symptoms and attitudes towards clinical trials.
What this means
The findings from the PeLear CCC study suggest that culturally and linguistically tailored educational videos can be highly effective in improving Colorectal Cancer symptom knowledge and fostering positive attitudes toward clinical trial participation among Spanish-speaking Latino individuals. The significant increase in knowledge scores and the high percentages of positive attitudes observed post-intervention underscore the potential of such educational tools to empower communities. These results imply that targeted educational strategies can play a crucial role in reducing health disparities, promoting informed decision-making regarding CRC screening, and enhancing enrollment in cancer clinical trials within underserved populations.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study NCT06426927, titled "PeLear CCC: Proyecto Latino Contra Cancer Colorrectal", were posted on 2026-01-14 on clinicaltrials.gov.