Trial results for a study focused on improving Colorectal Cancer screening in racially diverse zip codes were posted on ClinicalTrials.gov on 2026-02-11. The study reported 92 participants completed colorectal cancer screening in the intervention group compared to 79 in the control group.
Background
Colorectal cancer (CRC) remains a significant public health concern, and early detection through screening is crucial for improving outcomes. However, disparities in screening rates persist, particularly among high-risk individuals in underserved communities. Addressing these disparities requires targeted interventions that are culturally sensitive and leverage modern tools. This study aimed to enhance CRC screening completion in a persistent poverty county by implementing an electronic health record-based automated identification program combined with culturally-sensitive screening navigation.
Trial design
This completed study enrolled 385 participants to investigate strategies for improving screening for Colorectal Cancer. The study's overarching goal was to increase screening completion among high-risk individuals in a persistent poverty county. It utilized an electronic health record-based automated identification program to target culturally-sensitive CRC screening navigation to individuals who had not completed an ordered colonoscopy or fecal immunochemical test (FIT). Participants were divided into an intervention group ("Patients Residing in 18 Zip Codes in Western and Southwestern Philadelphia") and a control group.
Key results
The trial reported several key measurements related to colorectal cancer screening and detection:
- Enrollment in Navigator Program (Feasibility):
- For "Patients Residing in 18 Zip Codes in Western and Southwestern Philadelphia", 79 Participants were enrolled in the navigator program.
- Completion of Colorectal Cancer Screening:
- For "Patients Residing in 18 Zip Codes in Western and Southwestern Philadelphia", 92 Participants completed colorectal cancer screening.
- For "Controls", 79 Participants completed colorectal cancer screening.
- Number of Participants With Adenoma Detection:
- For "Patients Residing in 18 Zip Codes in Western and Southwestern Philadelphia", 21 Participants had adenoma detection.
- For "Controls", 15 Participants had adenoma detection.
What this means
The results indicate that the intervention, which combined an electronic health record-based identification program with culturally-sensitive navigation, led to a higher number of participants completing colorectal cancer screening in the intervention group (92) compared to the control group (79). Additionally, the intervention group showed a higher number of participants with adenoma detection (21 vs. 15 in controls), which could suggest improved detection of precancerous lesions. These findings suggest that targeted navigation strategies, particularly in high-risk, underserved populations, may be effective in increasing screening adherence and potentially improving early detection rates for colorectal cancer.
Source
The information regarding these trial results was obtained from ClinicalTrials.gov, a public database of clinical studies. The results for the study "Improving Colorectal Cancer Screening in Racially Diverse Zip Codes Using Navigation and Machine Learning (PCSNaP)" were posted on 2026-02-11 on clinicaltrials.gov.